PRDM4 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description PR domain containing 4|The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. An elevated expression level of this gene has been observed in PC12 cells treated with nerve growth factor, beta polypeptide (NGF). This gene is located in a chromosomal region that is thought to contain tumor suppressor genes. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 11108)
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Genes

295 genes differentially expressed following the PRDM4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
WDR38 WD repeat domain 38 3.05036
CDH5 cadherin 5, type 2 (vascular endothelium) 3.05036
CHRND cholinergic receptor, nicotinic, delta (muscle) 3.05036
SCG2 secretogranin II 3.05036
CTRL chymotrypsin-like 3.05036
IZUMO3 IZUMO family member 3 3.05036
OR52A5 olfactory receptor, family 52, subfamily A, member 5 3.05036
PRSS41 protease, serine, 41 3.05036
PON1 paraoxonase 1 3.05036
FGD2 FYVE, RhoGEF and PH domain containing 2 3.05036
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 3.05036
SOX7 SRY (sex determining region Y)-box 7 3.05036
IL12RB1 interleukin 12 receptor, beta 1 3.05036
DNAI2 dynein, axonemal, intermediate chain 2 3.05036
HHEX hematopoietically expressed homeobox 3.05036
TAS2R38 taste receptor, type 2, member 38 3.05036
USH1G Usher syndrome 1G (autosomal recessive) 3.05036
NDRG1 N-myc downstream regulated 1 3.05036
MAMSTR MEF2 activating motif and SAP domain containing transcriptional regulator 3.05036
TPBGL trophoblast glycoprotein-like 3.05036
RAX retina and anterior neural fold homeobox 3.05036
BTLA B and T lymphocyte associated 3.05036
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 3.05036
TRPV5 transient receptor potential cation channel, subfamily V, member 5 3.05036
DLX4 distal-less homeobox 4 3.05036
LRRC63 leucine rich repeat containing 63 3.05036
MUC20 mucin 20, cell surface associated 3.05036
TBATA thymus, brain and testes associated 3.05036
PTK6 protein tyrosine kinase 6 3.05036
FAM216B family with sequence similarity 216, member B 3.05036
ANKRD34A ankyrin repeat domain 34A 3.05036
TRIM73 tripartite motif containing 73 3.05036
MID2 midline 2 3.05036
AZGP1 alpha-2-glycoprotein 1, zinc-binding 3.05036
GSTM5 glutathione S-transferase mu 5 3.05036
CSTL1 cystatin-like 1 3.05036
ARHGAP36 Rho GTPase activating protein 36 3.05036
OLIG1 oligodendrocyte transcription factor 1 3.05036
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 3.05036
TLX3 T-cell leukemia homeobox 3 3.05036
SSTR4 somatostatin receptor 4 3.05036
MPL MPL proto-oncogene, thrombopoietin receptor 3.05036
TUBA3D tubulin, alpha 3d 3.05036
CPNE8-AS1 CPNE8 antisense RNA 1 3.05036
ROPN1L rhophilin associated tail protein 1-like 3.05036
OPRM1 opioid receptor, mu 1 3.05036
MGAM maltase-glucoamylase 3.05036
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 3.05036
PROX2 prospero homeobox 2 3.05036
XKR3 XK, Kell blood group complex subunit-related family, member 3 3.05036
GRAP GRB2-related adaptor protein 3.05036
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 3.05036
RAG1 recombination activating gene 1 3.05036
CAVIN2 caveolae associated protein 2 3.05036
CCDC9B coiled-coil domain containing 9B 3.05036
ZNF593OS ZNF593 opposite strand 3.05036
CD8B2 CD8b2 molecule 3.05036
SMIM35 small integral membrane protein 35 3.05036
MEIOSIN meiosis initiator 3.05036
TMEM270 transmembrane protein 270 3.05036
PLPP4 phospholipid phosphatase 4 3.05036
PLAAT4 phospholipase A and acyltransferase 4 3.05036
HTD2 hydroxyacyl-thioester dehydratase type 2 3.05036
C15ORF62 chromosome 15 open reading frame 62 3.05036
MLANA melan-A 3.05036
BHLHA9 basic helix-loop-helix family, member a9 3.05036
TFEC transcription factor EC 3.05036
SIM2 single-minded family bHLH transcription factor 2 3.05036
SLC22A25 solute carrier family 22, member 25 3.05036
CBLN2 cerebellin 2 precursor 3.05036
IL31RA interleukin 31 receptor A 3.05036
CLIP4 CAP-GLY domain containing linker protein family, member 4 3.05036
CHRD chordin 3.05036
TPTE transmembrane phosphatase with tensin homology 3.05036
MYH15 myosin, heavy chain 15 3.05036
PRRT4 proline-rich transmembrane protein 4 3.05036
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) 3.05036
SOAT2 sterol O-acyltransferase 2 3.05036
TMEM119 transmembrane protein 119 3.05036
NPIPB7 nuclear pore complex interacting protein family, member B7 3.05036
MPPED1 metallophosphoesterase domain containing 1 3.05036
PGA5 pepsinogen 5, group I (pepsinogen A) 3.05036
CLEC17A C-type lectin domain family 17, member A 3.05036
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 3.05036
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 3.05036
NPAS4 neuronal PAS domain protein 4 3.05036
CTAG1A cancer/testis antigen 1A 3.05036
S100Z S100 calcium binding protein Z 3.05036
GCOM1 GRINL1A complex locus 1 3.05036
NOX1 NADPH oxidase 1 3.05036
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 3.05036
FAM177B family with sequence similarity 177, member B 3.05036
SERINC4 serine incorporator 4 3.05036
C11ORF16 chromosome 11 open reading frame 16 3.05036
C6ORF163 chromosome 6 open reading frame 163 3.05036
HCRT hypocretin (orexin) neuropeptide precursor 3.05036
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 3.05036
TBC1D28 TBC1 domain family, member 28 3.05036
ANKRD62 ankyrin repeat domain 62 3.05036
DIABLO diablo, IAP-binding mitochondrial protein 3.05036
IL17REL interleukin 17 receptor E-like 3.05036
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.05036
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 3.05036
HBE1 hemoglobin, epsilon 1 3.05036
OPRK1 opioid receptor, kappa 1 3.05036
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 3.05036
CDH10 cadherin 10, type 2 (T2-cadherin) 3.05036
GPR62 G protein-coupled receptor 62 3.05036
IDI2 isopentenyl-diphosphate delta isomerase 2 3.05036
SH2D1B SH2 domain containing 1B 3.05036
CSF1R colony stimulating factor 1 receptor 3.05036
PCDHAC1 protocadherin alpha subfamily C, 1 3.05036
HPGDS hematopoietic prostaglandin D synthase 3.05036
TEX26 testis expressed 26 3.05036
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 3.05036
GPR61 G protein-coupled receptor 61 3.05036
TPPP2 tubulin polymerization-promoting protein family member 2 3.05036
SLCO2B1 solute carrier organic anion transporter family, member 2B1 3.05036
HUS1B HUS1 checkpoint homolog b (S. pombe) 3.05036
PCDHGA2 protocadherin gamma subfamily A, 2 3.05036
CRHR1 corticotropin releasing hormone receptor 1 3.05036
EVPLL envoplakin-like 3.05036
IL1A interleukin 1, alpha 3.05036
FBXO47 F-box protein 47 3.05036
ASTL astacin-like metallo-endopeptidase (M12 family) 3.05036
C8B complement component 8, beta polypeptide 3.05036
SLC36A3 solute carrier family 36, member 3 3.05036
METTL21C methyltransferase like 21C 3.05036
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 3.05036
ANGPTL3 angiopoietin-like 3 3.05036
TEX35 testis expressed 35 3.05036
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) 3.05036
ZPLD1 zona pellucida-like domain containing 1 3.05036
ANGPTL7 angiopoietin-like 7 3.05036
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 3.05036
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 3.05036
MAGEC3 melanoma antigen family C3 3.05036
CD226 CD226 molecule 3.05036
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 3.05036
TLDC2 TBC/LysM-associated domain containing 2 3.05036
FAM9B family with sequence similarity 9, member B 3.05036
AIRE autoimmune regulator 3.05036
GALR3 galanin receptor 3 3.05036
IL10RA interleukin 10 receptor, alpha 3.05036
CD8B CD8b molecule 3.05036
LGALS9 lectin, galactoside-binding, soluble, 9 3.05036
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 3.05036
CD80 CD80 molecule 3.05036
SLC51B solute carrier family 51, beta subunit 3.05036
FOXP3 forkhead box P3 3.05036
PRMT6 protein arginine methyltransferase 6 3.01639
CYS1 cystin 1 2.9211
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 2.90096
H2BC14 H2B clustered histone 14 2.83207
C5ORF15 chromosome 5 open reading frame 15 2.7838
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 2.74454
H4C9 H4 clustered histone 9 2.65953
PCTP phosphatidylcholine transfer protein 2.56751
WBP2 WW domain binding protein 2 2.51162
TCF7 transcription factor 7 (T-cell specific, HMG-box) 2.47379
ELAC2 elaC ribonuclease Z 2 2.43436
SPICP3 Spi-C transcription factor pseudogene 3 2.43257
ADGRL4 adhesion G protein-coupled receptor L4 2.43257
GPATCH11 G patch domain containing 11 2.42373
ACP3 acid phosphatase 3 2.3561
FER fer (fps/fes related) tyrosine kinase 2.33505
RBM20 RNA binding motif protein 20 2.33262
NCALD neurocalcin delta 2.30741
ZNF622 zinc finger protein 622 2.3014
PTCD2 pentatricopeptide repeat domain 2 2.3014
PLK5 polo-like kinase 5 2.2701
FIBP fibroblast growth factor (acidic) intracellular binding protein 2.26587
DRC11 dynein regulatory complex subunit 11 2.21137
C10ORF95 chromosome 10 open reading frame 95 2.20293
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.18746
SLC75A1 solute carrier family 75 member 1 2.18061
DNAH9 dynein, axonemal, heavy chain 9 2.13285
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 2.11768
LY6G5B lymphocyte antigen 6 complex, locus G5B 2.1152
GPRASP2 G protein-coupled receptor associated sorting protein 2 2.10633
ZDHHC9 zinc finger, DHHC-type containing 9 2.10508
TMC7 transmembrane channel-like 7 2.09409
PITPNA phosphatidylinositol transfer protein, alpha 2.08789
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 2.08158
DOT1L DOT1-like histone H3K79 methyltransferase 2.04731
TRIM13 tripartite motif containing 13 2.04172
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.02907

decreased expression

Symbol Name Standardized Value
KCNRG potassium channel regulator -3.05036
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 -3.05036
PAX3 paired box 3 -3.05036
ARHGAP30 Rho GTPase activating protein 30 -3.05036
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 -3.05036
MBOAT4 membrane bound O-acyltransferase domain containing 4 -3.05036
PRSS53 protease, serine, 53 -3.05036
MEI1 meiosis inhibitor 1 -3.05036
ASPA aspartoacylase -3.05036
CERCAM cerebral endothelial cell adhesion molecule -3.05036
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 -3.05036
SFTPD surfactant protein D -3.05036
F2 coagulation factor II (thrombin) -3.05036
ACOT12 acyl-CoA thioesterase 12 -3.05036
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 -3.05036
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) -3.05036
CSNK2A3 casein kinase 2, alpha 3 polypeptide -3.05036
PANO1 proapoptotic nucleolar protein 1 -3.05036
PROB1 proline-rich basic protein 1 -3.05036
CXCR4 chemokine (C-X-C motif) receptor 4 -3.05036
OR4D1 olfactory receptor, family 4, subfamily D, member 1 -3.05036
NTN5 netrin 5 -3.05036
GOLGA6L7 golgin A6 family like 7 -3.05036
CCN3 cellular communication network factor 3 -3.05036
PDCD1LG2 programmed cell death 1 ligand 2 -3.05036
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 -3.05036
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 -3.05036
MYZAP myocardial zonula adherens protein -3.05036
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 -3.05036
KLB klotho beta -3.05036
GPR37L1 G protein-coupled receptor 37 like 1 -3.05036
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 -3.05036
CAGE1 cancer antigen 1 -3.05036
DAO D-amino-acid oxidase -3.05036
ARL5C ADP-ribosylation factor-like 5C -3.05036
ZNF682 zinc finger protein 682 -3.05036
MLH3 mutL homolog 3 -3.05036
SLC38A8 solute carrier family 38, member 8 -3.05036
FBXL4 F-box and leucine-rich repeat protein 4 -2.97493
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.96207
PTPN9 protein tyrosine phosphatase, non-receptor type 9 -2.90096
AGBL5 ATP/GTP binding protein-like 5 -2.78958
CORIN corin, serine peptidase -2.75718
ASNS asparagine synthetase (glutamine-hydrolyzing) -2.72965
INTS9 integrator complex subunit 9 -2.7185
OGN osteoglycin -2.68812
PPP1R1C protein phosphatase 1, regulatory (inhibitor) subunit 1C -2.59548
PCDHGB6 protocadherin gamma subfamily B, 6 -2.59239
MBLAC1 metallo-beta-lactamase domain containing 1 -2.59239
FBXL22 F-box and leucine-rich repeat protein 22 -2.59239
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1 -2.56696
AMACR alpha-methylacyl-CoA racemase -2.56641
TPH1 tryptophan hydroxylase 1 -2.50306
SHISAL2A shisa like 2A -2.50306
KLF5 Kruppel-like factor 5 (intestinal) -2.50306
KIF3A kinesin family member 3A -2.43493
NPR1 natriuretic peptide receptor 1 -2.43436
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase -2.43257
ZNF827 zinc finger protein 827 -2.42373
ATM ATM serine/threonine kinase -2.41723
PFDN6 prefoldin subunit 6 -2.35876
CREB5 cAMP responsive element binding protein 5 -2.33565
TZMP1 transition zone microprotein 1 -2.32299
CDK11A cyclin-dependent kinase 11A -2.313
PRDM4 PR domain containing 4 -2.28271
IPCEF1 interaction protein for cytohesin exchange factors 1 -2.23516
PRXL2B peroxiredoxin like 2B -2.20996
CCDC124 coiled-coil domain containing 124 -2.20903
ELAVL3 ELAV like neuron-specific RNA binding protein 3 -2.20375
NEGR1 neuronal growth regulator 1 -2.20375
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) -2.20021
CENPP centromere protein P -2.1907
ALOX12B arachidonate 12-lipoxygenase, 12R type -2.18746
C11ORF24 chromosome 11 open reading frame 24 -2.18695
GPM6B glycoprotein M6B -2.18413
MAP2K5-DT MAP2K5 divergent transcript -2.18382
CATSPER4 cation channel, sperm associated 4 -2.18382
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -2.18382
SMOC1 SPARC related modular calcium binding 1 -2.17112
HCN3 hyperpolarization activated cyclic nucleotide gated potassium channel 3 -2.17112
SPRYD3 SPRY domain containing 3 -2.17112
RHBG Rh family, B glycoprotein (gene/pseudogene) -2.16877
FAM50B family with sequence similarity 50, member B -2.16877
AMN1 antagonist of mitotic exit network 1 homolog (S. cerevisiae) -2.15485
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 -2.15335
NCAPG non-SMC condensin I complex, subunit G -2.15335
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) -2.14313
PRRC1 proline-rich coiled-coil 1 -2.12879
PLD1 phospholipase D1, phosphatidylcholine-specific -2.1196
PPP2R5B protein phosphatase 2, regulatory subunit B', beta -2.11341
AAAS achalasia, adrenocortical insufficiency, alacrimia -2.10508
SCART1 scavenger receptor protein family member -2.10508
RNASE4 ribonuclease, RNase A family, 4 -2.10508
CORT cortistatin -2.10508
ECT2L epithelial cell transforming 2 like -2.10508
MYT1L myelin transcription factor 1-like -2.10508
TRIM69 tripartite motif containing 69 -2.10508
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -2.08928
SH3BGR SH3 domain binding glutamate-rich protein -2.08861
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit -2.08861
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 -2.05832
TFB1M transcription factor B1, mitochondrial -2.05832
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) -2.02857
NPIPB2 nuclear pore complex interacting protein family member B2 -2.02794
MAPRE1 microtubule-associated protein, RP/EB family, member 1 -2.02438
TCF12 transcription factor 12 -2.02438
HRH3 histamine receptor H3 -2.01651
KATNB1 katanin p80 (WD repeat containing) subunit B 1 -2.01038