PRKAA1 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description protein kinase, AMP-activated, alpha 1 catalytic subunit|The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5562)
External Link http://www.ncbi.nlm.nih.gov/gene/5562
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Genes

57 substrates of the kinase PRKAA1 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ACACB acetyl-CoA carboxylase beta
ATG9A autophagy related 9A
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CGN cingulin
CRY1 cryptochrome circadian clock 1
CSNK1E casein kinase 1, epsilon
CTBP1 C-terminal binding protein 1
EEF2K eukaryotic elongation factor 2 kinase
EP300 E1A binding protein p300
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
FOXO3 forkhead box O3
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GFPT1 glutamine--fructose-6-phosphate transaminase 1
HDAC5 histone deacetylase 5
HIST1H2BB histone cluster 1, H2bb
HIST1H2BN histone cluster 1, H2bn
HNF4A hepatocyte nuclear factor 4, alpha
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLC1 kinesin light chain 1
KLC2 kinesin light chain 2
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LIPE lipase, hormone-sensitive
MAP4 microtubule-associated protein 4
MAPT microtubule-associated protein tau
MED1 mediator complex subunit 1
MFF mitochondrial fission factor
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NOS3 nitric oxide synthase 3 (endothelial cell)
NR2C2 nuclear receptor subfamily 2, group C, member 2
PDLIM5 PDZ and LIM domain 5
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIKFYVE phosphoinositide kinase, FYVE finger containing
PNPLA2 patatin-like phospholipase domain containing 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RB1 retinoblastoma 1
RPTOR regulatory associated protein of MTOR, complex 1
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
SIRT2 sirtuin 2
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1
SREBF1 sterol regulatory element binding transcription factor 1
SYK spleen tyrosine kinase
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TNNI3 troponin I type 3 (cardiac)
TP53 tumor protein p53
TP73 tumor protein p73
ULK1 unc-51 like autophagy activating kinase 1
VASP vasodilator-stimulated phosphoprotein
YAP1 Yes-associated protein 1
ZNF692 zinc finger protein 692