PRKAA2 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description protein kinase, AMP-activated, alpha 2 catalytic subunit|The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5563)
External Link http://www.ncbi.nlm.nih.gov/gene/5563
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17 substrates of the kinase PRKAA2 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
ACACA acetyl-CoA carboxylase alpha
BAIAP2 BAI1-associated protein 2
CDC27 cell division cycle 27
EEF2K eukaryotic elongation factor 2 kinase
FOXO3 forkhead box O3
HAS2 hyaluronan synthase 2
HDAC5 histone deacetylase 5
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PARP1 poly (ADP-ribose) polymerase 1
PLD1 phospholipase D1, phosphatidylcholine-specific
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP1R12C protein phosphatase 1, regulatory subunit 12C
TBC1D4 TBC1 domain family, member 4
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TP53 tumor protein p53
VASP vasodilator-stimulated phosphoprotein