PRKAB1 Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description protein kinase, AMP-activated, beta 1 non-catalytic subunit|The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5564)
External Link http://www.ncbi.nlm.nih.gov/gene/5564
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Genes

185 interacting proteins for hub protein PRKAB1 from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1
ACACA acetyl-CoA carboxylase alpha
ACACB acetyl-CoA carboxylase beta
ACAT2 acetyl-CoA acetyltransferase 2
ACLY ATP citrate lyase
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
API5 apoptosis inhibitor 5
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
BCCIP BRCA2 and CDKN1A interacting protein
CACYBP calcyclin binding protein
CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1
CASP14 caspase 14, apoptosis-related cysteine peptidase
CBR1 carbonyl reductase 1
CCDC88A coiled-coil domain containing 88A
CDC37 cell division cycle 37
CDK1 cyclin-dependent kinase 1
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CIDEA cell death-inducing DFFA-like effector a
CISD1 CDGSH iron sulfur domain 1
CLTC clathrin, heavy chain (Hc)
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
CNIH4 cornichon family AMPA receptor auxiliary protein 4
COPB2 coatomer protein complex, subunit beta 2 (beta prime)
COTL1 coactosin-like F-actin binding protein 1
CPVL carboxypeptidase, vitellogenic-like
CSDE1 cold shock domain containing E1, RNA-binding
CTPS1 CTP synthase 1
CYB5R3 cytochrome b5 reductase 3
CYCS cytochrome c, somatic
DDB1 damage-specific DNA binding protein 1, 127kDa
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36
DNM2 dynamin 2
DSC1 desmocollin 1
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EFTUD2 elongation factor Tu GTP binding domain containing 2
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF3H eukaryotic translation initiation factor 3, subunit H
EIF3K eukaryotic translation initiation factor 3, subunit K
EIF3M eukaryotic translation initiation factor 3, subunit M
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EIF6 eukaryotic translation initiation factor 6
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERH enhancer of rudimentary homolog (Drosophila)
ETFA electron-transfer-flavoprotein, alpha polypeptide
EWSR1 EWS RNA-binding protein 1
EZR ezrin
F10 coagulation factor X
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM98B family with sequence similarity 98, member B
FH fumarate hydratase
FHL1 four and a half LIM domains 1
FNIP1 folliculin interacting protein 1
FSCN1 fascin actin-bundling protein 1
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
GDI2 GDP dissociation inhibitor 2
GMPS guanine monphosphate synthase
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial
GRB2 growth factor receptor-bound protein 2
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
GRWD1 glutamate-rich WD repeat containing 1
GSK3B glycogen synthase kinase 3 beta
GSPT1 G1 to S phase transition 1
GYS1 glycogen synthase 1 (muscle)
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HDAC5 histone deacetylase 5
HMGB3 high mobility group box 3
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA4L heat shock 70kDa protein 4-like
IPO9 importin 9
KIF5B kinesin family member 5B
LRRC59 leucine rich repeat containing 59
MARS methionyl-tRNA synthetase
MAT2A methionine adenosyltransferase II, alpha
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MRPS16 mitochondrial ribosomal protein S16
MSN moesin
MTPN myotrophin
MYH10 myosin, heavy chain 10, non-muscle
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa
NPEPPS aminopeptidase puromycin sensitive
NSF N-ethylmaleimide-sensitive factor
NUAK1 NUAK family, SNF1-like kinase, 1
NUDC nudC nuclear distribution protein
NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5
NUP93 nucleoporin 93kDa
NXT1 nuclear transport factor 2-like export factor 1
OAT ornithine aminotransferase
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
PA2G4 proliferation-associated 2G4, 38kDa
PABPC1 poly(A) binding protein, cytoplasmic 1
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PARP1 poly (ADP-ribose) polymerase 1
PCGF6 polycomb group ring finger 6
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PFDN2 prefoldin subunit 2
PFKP phosphofructokinase, platelet
PFN2 profilin 2
PGD phosphogluconate dehydrogenase
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
PREP prolyl endopeptidase
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRPF8 pre-mRNA processing factor 8
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
QPCTL glutaminyl-peptide cyclotransferase-like
RAB7A RAB7A, member RAS oncogene family
RANGAP1 Ran GTPase activating protein 1
RCC1 regulator of chromosome condensation 1
RCC2 regulator of chromosome condensation 2
RNF219 ring finger protein 219
RNMTL1 RNA methyltransferase like 1
RPL21 ribosomal protein L21
RPL3 ribosomal protein L3
RPL31 ribosomal protein L31
RPL35A ribosomal protein L35a
RPL36 ribosomal protein L36
RPS27A ribosomal protein S27a
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS9 ribosomal protein S9
RRM1 ribonucleotide reductase M1
RTN4 reticulon 4
RUVBL2 RuvB-like AAA ATPase 2
S100A9 S100 calcium binding protein A9
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SET SET nuclear proto-oncogene
SF3A1 splicing factor 3a, subunit 1, 120kDa
SF3B6 splicing factor 3b, subunit 6, 14kDa
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SND1 staphylococcal nuclease and tudor domain containing 1
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein)
SSB Sjogren syndrome antigen B (autoantigen La)
SSR4 signal sequence receptor, delta
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STK11 serine/threonine kinase 11
STRAP serine/threonine kinase receptor associated protein
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TARS threonyl-tRNA synthetase
TARSL2 threonyl-tRNA synthetase-like 2
TGM3 transglutaminase 3
TRIM28 tripartite motif containing 28
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae)
TSN translin
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UBE2L3 ubiquitin-conjugating enzyme E2L 3
UBE2N ubiquitin-conjugating enzyme E2N
UFM1 ubiquitin-fold modifier 1
ULK2 unc-51 like autophagy activating kinase 2
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VAMP3 vesicle-associated membrane protein 3
VMA21 VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae)
WBSCR22 Williams Beuren syndrome chromosome region 22