PRKACA Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description protein kinase, cAMP-dependent, catalytic, alpha|This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms. [provided by RefSeq, Jan 2015] (NCBI Entrez Gene Database, 5566)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/MORF_PRKACA
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Genes

111 co-expressed genes for PRKACA from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
AQP5 aquaporin 5
AQP7 aquaporin 7
ARL3 ADP-ribosylation factor-like 3
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BCL2 B-cell CLL/lymphoma 2
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1
BRCA1 breast cancer 1, early onset
C1ORF216 chromosome 1 open reading frame 216
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCKAR cholecystokinin A receptor
CD6 CD6 molecule
CDR2L cerebellar degeneration-related protein 2-like
CELA2B chymotrypsin-like elastase family, member 2B
CFH complement factor H
CLOCK clock circadian regulator
CNKSR1 connector enhancer of kinase suppressor of Ras 1
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DPT dermatopontin
EPHB2 EPH receptor B2
ERC1 ELKS/RAB6-interacting/CAST family member 1
ESR1 estrogen receptor 1
EXTL3 exostosin-like glycosyltransferase 3
FAM189A2 family with sequence similarity 189, member A2
FIG4 FIG4 phosphoinositide 5-phosphatase
FNTB farnesyltransferase, CAAX box, beta
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GH1 growth hormone 1
GJB5 gap junction protein, beta 5, 31.1kDa
GLE1 GLE1 RNA export mediator
GNPAT glyceronephosphate O-acyltransferase
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GRIK5 glutamate receptor, ionotropic, kainate 5
GSK3B glycogen synthase kinase 3 beta
HMOX2 heme oxygenase 2
HOXA11 homeobox A11
HOXD4 homeobox D4
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IFT27 intraflagellar transport 27
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL13 interleukin 13
IRF2 interferon regulatory factor 2
IRS2 insulin receptor substrate 2
JAG1 jagged 1
JRK Jrk homolog (mouse)
KAT8 K(lysine) acetyltransferase 8
KIAA0195 KIAA0195
KLHL18 kelch-like family member 18
KRT33A keratin 33A, type I
LTBP4 latent transforming growth factor beta binding protein 4
LY9 lymphocyte antigen 9
MAPT microtubule-associated protein tau
MC5R melanocortin 5 receptor
MFN1 mitofusin 1
MSH3 mutS homolog 3
MSX1 msh homeobox 1
MYO9B myosin IXB
NF1 neurofibromin 1
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NR2C1 nuclear receptor subfamily 2, group C, member 1
NRTN neurturin
NXPE3 neurexophilin and PC-esterase domain family, member 3
OPLAH 5-oxoprolinase (ATP-hydrolysing)
PAX9 paired box 9
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PCGF1 polycomb group ring finger 1
PGM3 phosphoglucomutase 3
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PIGF phosphatidylinositol glycan anchor biosynthesis, class F
PIGR polymeric immunoglobulin receptor
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
POU6F1 POU class 6 homeobox 1
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PVR poliovirus receptor
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
SCAPER S-phase cyclin A-associated protein in the ER
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1
SLC22A6 solute carrier family 22 (organic anion transporter), member 6
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SMYD5 SMYD family member 5
SP140 SP140 nuclear body protein
STK17A serine/threonine kinase 17a
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TBC1D22A TBC1 domain family, member 22A
TBX5 T-box 5
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TMEM11 transmembrane protein 11
TMPRSS6 transmembrane protease, serine 6
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
WBP4 WW domain binding protein 4
WT1 Wilms tumor 1
ZBTB22 zinc finger and BTB domain containing 22
ZNF500 zinc finger protein 500
ZNF592 zinc finger protein 592