PRKAR1A Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description protein kinase, cAMP-dependent, regulatory, type I, alpha|cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013] (NCBI Entrez Gene Database, 5573)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/MORF_PRKAR1A
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Genes

142 co-expressed genes for PRKAR1A from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ABR active BCR-related
AHCYL1 adenosylhomocysteinase-like 1
AP2M1 adaptor-related protein complex 2, mu 1 subunit
AP3D1 adaptor-related protein complex 3, delta 1 subunit
ARCN1 archain 1
ARF3 ADP-ribosylation factor 3
ARF5 ADP-ribosylation factor 5
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
ATOX1 antioxidant 1 copper chaperone
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
ATXN2 ataxin 2
BANF1 barrier to autointegration factor 1
BCAP31 B-cell receptor-associated protein 31
BZW1 basic leucine zipper and W2 domains 1
C21ORF33 chromosome 21 open reading frame 33
CALM2 calmodulin 2 (phosphorylase kinase, delta)
CANX calnexin
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1
CAPZB capping protein (actin filament) muscle Z-line, beta
CFDP1 craniofacial development protein 1
CLN3 ceroid-lipofuscinosis, neuronal 3
CLTA clathrin, light chain A
CNIH1 cornichon family AMPA receptor auxiliary protein 1
COG4 component of oligomeric golgi complex 4
COPS5 COP9 signalosome subunit 5
COX4I1 cytochrome c oxidase subunit IV isoform 1
COX5B cytochrome c oxidase subunit Vb
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1
COX6C cytochrome c oxidase subunit VIc
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like
COX7C cytochrome c oxidase subunit VIIc
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous)
CTDNEP1 CTD nuclear envelope phosphatase 1
CYC1 cytochrome c-1
DAP3 death associated protein 3
DCTN2 dynactin 2 (p50)
DNPEP aspartyl aminopeptidase
DRG1 developmentally regulated GTP binding protein 1
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2
DYNLL1 dynein, light chain, LC8-type 1
EBAG9 estrogen receptor binding site associated, antigen, 9
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EFCAB14 EF-hand calcium binding domain 14
EIF4E2 eukaryotic translation initiation factor 4E family member 2
ENSA endosulfine alpha
FAM120A family with sequence similarity 120A
FBXW11 F-box and WD repeat domain containing 11
GANAB glucosidase, alpha; neutral AB
GLB1 galactosidase, beta 1
GMFB glia maturation factor, beta
GORASP2 golgi reassembly stacking protein 2, 55kDa
GPAA1 glycosylphosphatidylinositol anchor attachment 1
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HSBP1 heat shock factor binding protein 1
HSPA8 heat shock 70kDa protein 8
IST1 increased sodium tolerance 1 homolog (yeast)
JTB jumping translocation breakpoint
KARS lysyl-tRNA synthetase
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
LAMP2 lysosomal-associated membrane protein 2
LYPLA1 lysophospholipase I
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
MBD4 methyl-CpG binding domain protein 4
MDH1 malate dehydrogenase 1, NAD (soluble)
METAP1 methionyl aminopeptidase 1
MORF4L2 mortality factor 4 like 2
MTA1 metastasis associated 1
MTDH metadherin
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYL12B myosin, light chain 12B, regulatory
NCBP2 nuclear cap binding protein subunit 2, 20kDa
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NSF N-ethylmaleimide-sensitive factor
PDCD6 programmed cell death 6
PGK1 phosphoglycerate kinase 1
PHF3 PHD finger protein 3
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11
PPP1R7 protein phosphatase 1, regulatory subunit 7
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PUF60 poly-U binding splicing factor 60KDa
PUM2 pumilio RNA-binding family member 2
RAB1A RAB1A, member RAS oncogene family
RAB5B RAB5B, member RAS oncogene family
RAB6A RAB6A, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD21 RAD21 homolog (S. pombe)
RAD23B RAD23 homolog B (S. cerevisiae)
RAN RAN, member RAS oncogene family
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RPN2 ribophorin II
RXRA retinoid X receptor, alpha
SARS seryl-tRNA synthetase
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SEPHS2 selenophosphate synthetase 2
SEPT2 septin 2
SETD3 SET domain containing 3
SHFM1 split hand/foot malformation (ectrodactyly) type 1
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SNRPE small nuclear ribonucleoprotein polypeptide E
SOD1 superoxide dismutase 1, soluble
SP3 Sp3 transcription factor
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae)
SRP9 signal recognition particle 9kDa
SSR2 signal sequence receptor, beta (translocon-associated protein beta)
STARD7 StAR-related lipid transfer (START) domain containing 7
SUMO1 small ubiquitin-like modifier 1
SUMO2 small ubiquitin-like modifier 2
TADA3 transcriptional adaptor 3
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM59 transmembrane protein 59
TOR1A torsin family 1, member A (torsin A)
TRAPPC3 trafficking protein particle complex 3
TUG1 taurine up-regulated 1 (non-protein coding)
UBA1 ubiquitin-like modifier activating enzyme 1
UBE2A ubiquitin-conjugating enzyme E2A
UGP2 UDP-glucose pyrophosphorylase 2
UQCRB ubiquinol-cytochrome c reductase binding protein
VGLL4 vestigial-like family member 4
WBP2 WW domain binding protein 2
XPC xeroderma pigmentosum, complementation group C
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZNF638 zinc finger protein 638