PRKCA Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description protein kinase C, alpha|Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5578)
External Link http://www.ncbi.nlm.nih.gov/gene/5578
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Genes

238 substrates of the kinase PRKCA from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACO1 aconitase 1, soluble
ADAM17 ADAM metallopeptidase domain 17
ADAP1 ArfGAP with dual PH domains 1
ADD1 adducin 1 (alpha)
ADD2 adducin 2 (beta)
ADRBK1 adrenergic, beta, receptor kinase 1
AFAP1 actin filament associated protein 1
AHR aryl hydrocarbon receptor
AICDA activation-induced cytidine deaminase
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANXA1 annexin A1
ANXA2 annexin A2
APLP1 amyloid beta (A4) precursor-like protein 1
APLP2 amyloid beta (A4) precursor-like protein 2
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
AQP1 aquaporin 1 (Colton blood group)
AQP4 aquaporin 4
AR androgen receptor
ARHGAP35 Rho GTPase activating protein 35
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATF2 activating transcription factor 2
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
BCL2 B-cell CLL/lymphoma 2
BDKRB2 bradykinin receptor B2
BEST1 bestrophin 1
BLVRA biliverdin reductase A
BNC1 basonuclin 1
C5AR1 complement component 5a receptor 1
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CASR calcium-sensing receptor
CD226 CD226 molecule
CD34 CD34 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD4 CD4 molecule
CD44 CD44 molecule (Indian blood group)
CD5 CD5 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CFL1 cofilin 1 (non-muscle)
CFLAR CASP8 and FADD-like apoptosis regulator
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHAT choline O-acetyltransferase
CLDN4 claudin 4
CLDN7 claudin 7
CORO1B coronin, actin binding protein, 1B
CREBBP CREB binding protein
CREM cAMP responsive element modulator
CTNND1 catenin (cadherin-associated protein), delta 1
CTPS1 CTP synthase 1
CYBA cytochrome b-245, alpha polypeptide
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYTH2 cytohesin 2
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DLG1 discs, large homolog 1 (Drosophila)
DLX3 distal-less homeobox 3
DMBT1 deleted in malignant brain tumors 1
DNM1 dynamin 1
DTNB dystrobrevin, beta
EGFR epidermal growth factor receptor
EGLN2 egl-9 family hypoxia-inducible factor 2
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EIF6 eukaryotic translation initiation factor 6
ELAVL1 ELAV like RNA binding protein 1
ENAH enabled homolog (Drosophila)
EP300 E1A binding protein p300
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
EWSR1 EWS RNA-binding protein 1
EZR ezrin
F11R F11 receptor
F3 coagulation factor III (thromboplastin, tissue factor)
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
FSCN1 fascin actin-bundling protein 1
FXYD1 FXYD domain containing ion transport regulator 1
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GLRB glycine receptor, beta
GMFB glia maturation factor, beta
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPSM2 G-protein signaling modulator 2
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRID2 glutamate receptor, ionotropic, delta 2
GRIK2 glutamate receptor, ionotropic, kainate 2
GRK7 G protein-coupled receptor kinase 7
GRM7 glutamate receptor, metabotropic 7
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GSTA4 glutathione S-transferase alpha 4
GSTP1 glutathione S-transferase pi 1
HABP4 hyaluronan binding protein 4
HEXIM1 hexamethylene bis-acetamide inducible 1
HIST1H2BB histone cluster 1, H2bb
HIST1H3A histone cluster 1, H3a
HOXA9 homeobox A9
HRH1 histamine receptor H1
HSPB1 heat shock 27kDa protein 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL2RA interleukin 2 receptor, alpha
ILK integrin-linked kinase
INSR insulin receptor
IQGAP1 IQ motif containing GTPase activating protein 1
IRS1 insulin receptor substrate 1
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB4 integrin, beta 4
JPH2 junctophilin 2
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT20 keratin 20, type I
L1CAM L1 cell adhesion molecule
LCK LCK proto-oncogene, Src family tyrosine kinase
LMNA lamin A/C
LRP1 low density lipoprotein receptor-related protein 1
MAPT microtubule-associated protein tau
MARCKS myristoylated alanine-rich protein kinase C substrate
MBD4 methyl-CpG binding domain protein 4
MET MET proto-oncogene, receptor tyrosine kinase
MKLN1 muskelin 1, intracellular mediator containing kelch motifs
MMP2 matrix metallopeptidase 2
MYBPC1 myosin binding protein C, slow type
MYBPC3 myosin binding protein C, cardiac
MYH9 myosin, heavy chain 9, non-muscle
MYL9 myosin, light chain 9, regulatory
MYOG myogenin (myogenic factor 4)
NCF1 neutrophil cytosolic factor 1
NCF4 neutrophil cytosolic factor 4, 40kDa
NCOR1 nuclear receptor corepressor 1
NFE2L2 nuclear factor, erythroid 2-like 2
NKX3-1 NK3 homeobox 1
NLGN4X neuroligin 4, X-linked
NMNAT1 nicotinamide nucleotide adenylyltransferase 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
NOXA1 NADPH oxidase activator 1
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR1I3 nuclear receptor subfamily 1, group I, member 3
NR2C1 nuclear receptor subfamily 2, group C, member 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
OCLN occludin
OPRD1 opioid receptor, delta 1
OPRM1 opioid receptor, mu 1
PA2G4 proliferation-associated 2G4, 38kDa
PDE3A phosphodiesterase 3A, cGMP-inhibited
PDLIM2 PDZ and LIM domain 2 (mystique)
PEA15 phosphoprotein enriched in astrocytes 15
PEBP1 phosphatidylethanolamine binding protein 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PITPNB phosphatidylinositol transfer protein, beta
PLAU plasminogen activator, urokinase
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCG1 phospholipase C, gamma 1
PLD2 phospholipase D2
PLEK pleckstrin
PPARA peroxisome proliferator-activated receptor alpha
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCE protein kinase C, epsilon
PRKD1 protein kinase D1
PRKD2 protein kinase D2
PRKD3 protein kinase D3
PRKG1 protein kinase, cGMP-dependent, type I
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRA protein tyrosine phosphatase, receptor type, A
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RALB v-ral simian leukemia viral oncogene homolog B
RALBP1 ralA binding protein 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RET ret proto-oncogene
RGS7 regulator of G-protein signaling 7
RHO rhodopsin
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RORA RAR-related orphan receptor A
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RRAD Ras-related associated with diabetes
RSC1A1 regulatory solute carrier protein, family 1, member 1
SH2B1 SH2B adaptor protein 1
SIK1 salt-inducible kinase 1
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNAP25 synaptosomal-associated protein, 25kDa
SPN sialophorin
SRF serum response factor (c-fos serum response element-binding transcription factor)
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN transgelin
TAGLN2 transgelin 2
TBXA2R thromboxane A2 receptor
TDG thymine-DNA glycosylase
TFRC transferrin receptor
TGFBR1 transforming growth factor, beta receptor 1
THOC5 THO complex 5
TMPO thymopoietin
TNNI3 troponin I type 3 (cardiac)
TNNT2 troponin T type 2 (cardiac)
TOP1 topoisomerase (DNA) I
TP53 tumor protein p53
TP73 tumor protein p73
TRAF2 TNF receptor-associated factor 2
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TRPV5 transient receptor potential cation channel, subfamily V, member 5
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TTN titin
TUBA1C tubulin, alpha 1c
TXN thioredoxin
VASP vasodilator-stimulated phosphoprotein
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VIM vimentin
VTN vitronectin