PRKCD Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description protein kinase C, delta|Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5580)
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Genes

296 genes differentially expressed following the PRKCD gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ZC2HC1B zinc finger, C2HC-type containing 1B 3.68427
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 3.68427
DRD3 dopamine receptor D3 3.68427
YIPF7 Yip1 domain family, member 7 3.68427
BMX BMX non-receptor tyrosine kinase 3.68427
ADAD2 adenosine deaminase domain containing 2 3.68427
NPFF neuropeptide FF-amide peptide precursor 3.68427
WDR93 WD repeat domain 93 3.68427
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 3.68427
IL36R interleukin 36 receptor 3.68427
TRPA1 transient receptor potential cation channel, subfamily A, member 1 3.68427
CDK20 cyclin-dependent kinase 20 3.68427
VWA7 von Willebrand factor A domain containing 7 3.68427
DCST1 DC-STAMP domain containing 1 3.68427
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 3.68427
CDC20B cell division cycle 20B 3.68427
LMX1A LIM homeobox transcription factor 1, alpha 3.68427
DRC1 dynein regulatory complex subunit 1 3.68427
THSD1 thrombospondin, type I, domain containing 1 3.68427
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 3.68427
CLEC20A C-type lectin domain containing 20A 3.68427
ARMH2 armadillo like helical domain containing 2 3.68427
C10ORF67 chromosome 10 open reading frame 67 3.68427
PCDHA5 protocadherin alpha 5 3.68427
SPMIP9 sperm microtubule inner protein 9 3.68427
OR52H1 olfactory receptor, family 52, subfamily H, member 1 3.54357
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 3.54357
TAS2R5 taste receptor, type 2, member 5 3.54357
FAM180A family with sequence similarity 180, member A 3.54357
ZNF503 zinc finger protein 503 3.54357
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 3.54357
CARD16 caspase recruitment domain family, member 16 3.54357
SIX2 SIX homeobox 2 3.54357
ASB15 ankyrin repeat and SOCS box containing 15 3.54357
PAX6 paired box 6 3.54357
DMRTC1B DMRT-like family C1B 3.54357
HIC1 hypermethylated in cancer 1 3.54357
ETV7 ets variant 7 3.54357
TMEM132C transmembrane protein 132C 3.54357
PCDHGB3 protocadherin gamma subfamily B, 3 3.54357
TBC1D3 TBC1 domain family, member 3 3.54357
BMP3 bone morphogenetic protein 3 3.54357
PRDM12 PR domain containing 12 3.54357
SETSIP SET-like protein 3.54357
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 3.54357
GUCY2F guanylate cyclase 2F, retinal 3.54357
BHLHE40 basic helix-loop-helix family, member e40 3.54357
TRPV5 transient receptor potential cation channel, subfamily V, member 5 3.54357
MYOM2 myomesin 2 3.54357
TMEM72 transmembrane protein 72 3.54357
FLI1 Fli-1 proto-oncogene, ETS transcription factor 3.54357
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 3.54357
RSPO3 R-spondin 3 3.54357
TDO2 tryptophan 2,3-dioxygenase 3.54357
TBX20 T-box 20 3.54357
OR5H6 olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene) 3.54357
MYH7 myosin, heavy chain 7, cardiac muscle, beta 3.54357
TRAPPC3L trafficking protein particle complex 3-like 3.54357
CLDN16 claudin 16 3.54357
LTB4R2 leukotriene B4 receptor 2 3.54357
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.54357
AVPR1B arginine vasopressin receptor 1B 3.54357
ARX aristaless related homeobox 3.54357
ERVW-1 endogenous retrovirus group W, member 1 3.54357
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 3.54357
CCDC9B coiled-coil domain containing 9B 3.54357
SMIM40 small integral membrane protein 40 3.54357
PPDPFL pancreatic progenitor cell differentiation and proliferation factor like 3.54357
PRRT1B proline rich transmembrane protein 1B 3.54357
C8ORF90 chromosome 8 open reading frame 90 3.54357
SPEGNB SPEG neighbor 3.54357
DRC5 dynein regulatory complex subunit 5 3.54357
ADGRG3 adhesion G protein-coupled receptor G3 3.54357
OR2T8 olfactory receptor, family 2, subfamily T, member 8 3.54357
MLN motilin 3.54357
PCDHA2 protocadherin alpha 2 3.54357
PTPRC protein tyrosine phosphatase, receptor type, C 3.54357
VIT vitrin 3.54357
CLIP4 CAP-GLY domain containing linker protein family, member 4 3.54357
TEX13C TEX13 family member C 3.54357
ZIC4 Zic family member 4 3.54357
OR2L2 olfactory receptor, family 2, subfamily L, member 2 3.54357
VCX3B variable charge, X-linked 3B 3.54357
FAM107A family with sequence similarity 107, member A 3.54357
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 3.54357
GATA1 GATA binding protein 1 (globin transcription factor 1) 3.54357
LY6K lymphocyte antigen 6 complex, locus K 3.54357
PROZ protein Z, vitamin K-dependent plasma glycoprotein 3.54357
PROX2 prospero homeobox 2 3.54357
LMNTD1 lamin tail domain containing 1 3.54357
PDF peptide deformylase (mitochondrial) 3.54357
SPMIP1 sperm microtubule inner protein 1 3.54357
FAM161B family with sequence similarity 161, member B 3.54357
TBXA2R thromboxane A2 receptor 3.54357
GSTA2 glutathione S-transferase alpha 2 3.54357
CTSF cathepsin F 3.54357
BRDT bromodomain, testis-specific 3.54357
PGR progesterone receptor 3.54357
KCNK9 potassium channel, two pore domain subfamily K, member 9 3.54357
DUOX2 dual oxidase 2 3.54357
SLC38A8 solute carrier family 38, member 8 3.54357
SMIM22 small integral membrane protein 22 3.54357
SHOX2 short stature homeobox 2 3.54357
OR13A1 olfactory receptor, family 13, subfamily A, member 1 3.54357
MAPK11 mitogen-activated protein kinase 11 3.54357
PSG9 pregnancy specific beta-1-glycoprotein 9 3.54357
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 3.54357
EDN3 endothelin 3 3.54357
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 3.54357
PAGE4 P antigen family, member 4 (prostate associated) 3.54357
C16ORF78 chromosome 16 open reading frame 78 3.54357
FRAT2 frequently rearranged in advanced T-cell lymphomas 2 3.54357
ISL2 ISL LIM homeobox 2 3.54357
HAVCR1 hepatitis A virus cellular receptor 1 3.54357
LRRK2 leucine-rich repeat kinase 2 3.54357
SV2B synaptic vesicle glycoprotein 2B 3.54357
CALHM2 calcium homeostasis modulator 2 3.54357
ADAM2 ADAM metallopeptidase domain 2 3.54357
BPIFB1 BPI fold containing family B, member 1 3.54357
FAM135B family with sequence similarity 135, member B 3.54357
NUPR1 nuclear protein, transcriptional regulator, 1 3.54357
KLK4 kallikrein-related peptidase 4 3.54357
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 3.54357
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase) 3.54357
IL17B interleukin 17B 3.54357
WNT1 wingless-type MMTV integration site family, member 1 3.54357
GPR17 G protein-coupled receptor 17 3.54357
FKBP1C FK506 binding protein 1C 3.54357
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 3.54357
ASCL2 achaete-scute family bHLH transcription factor 2 3.54357
PADI1 peptidyl arginine deiminase, type I 3.54357
GHRH growth hormone releasing hormone 3.54357
ZPBP zona pellucida binding protein 3.54357
ANXA2R annexin A2 receptor 3.54357
GRM6 glutamate receptor, metabotropic 6 3.54357
GPR78 G protein-coupled receptor 78 3.54357
BTBD18 BTB (POZ) domain containing 18 3.54357
ANXA1 annexin A1 3.54357
CCDC166 coiled-coil domain containing 166 3.54357
SPTA1 spectrin, alpha, erythrocytic 1 3.54357
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 3.54357
MEIS1 Meis homeobox 1 3.54357
RGS4 regulator of G-protein signaling 4 3.54357
RIN1 Ras and Rab interactor 1 3.54357
LHCGR luteinizing hormone/choriogonadotropin receptor 3.4388
OSBPL7 oxysterol binding protein-like 7 3.4388
SERTAD4 SERTA domain containing 4 3.22191
JAK2 Janus kinase 2 3.16633
BRSK1 BR serine/threonine kinase 1 2.99305
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) 2.89331
F2 coagulation factor II (thrombin) 2.84314
A4GALT alpha 1,4-galactosyltransferase 2.82401
ELAPOR2 endosome-lysosome associated apoptosis and autophagy regulator family member 2 2.8095
RINL Ras and Rab interactor-like 2.80128
ATG5 autophagy related 5 2.60813
ERICH2 glutamate-rich 2 2.59288
BEGAIN brain-enriched guanylate kinase-associated 2.5778
ANKRD13A ankyrin repeat domain 13A 2.54989
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 2.53948
LPCAT3 lysophosphatidylcholine acyltransferase 3 2.47513
RAB11B RAB11B, member RAS oncogene family 2.428
KLF10 Kruppel-like factor 10 2.36595
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 2.36595
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.36595
TRIP11 thyroid hormone receptor interactor 11 2.36324
OVCH2 ovochymase 2 (gene/pseudogene) 2.35854
AMBP alpha-1-microglobulin/bikunin precursor 2.35854
TMEM255A transmembrane protein 255A 2.35854
PRPF4 pre-mRNA processing factor 4 2.35712
FMN2 formin 2 2.35712
GNPAT glyceronephosphate O-acyltransferase 2.33706
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 2.33704
EVI5 ecotropic viral integration site 5 2.31856
KIAA0513 KIAA0513 2.31226
ACACB acetyl-CoA carboxylase beta 2.31094
ZNF460 zinc finger protein 460 2.31094
TP53I11 tumor protein p53 inducible protein 11 2.31032
FHIP2A FHF complex subunit HOOK interacting protein 2A 2.30343
CFDP1 craniofacial development protein 1 2.30079
ANKDD1B ankyrin repeat and death domain containing 1B 2.2897
APC adenomatous polyposis coli 2.2857
FRMD3 FERM domain containing 3 2.28037
CHRM2 cholinergic receptor, muscarinic 2 2.26363
PRSS36 protease, serine, 36 2.26363
TTC12 tetratricopeptide repeat domain 12 2.26363
MAMDC4 MAM domain containing 4 2.26363
TGM2 transglutaminase 2 2.26363
EPCAM epithelial cell adhesion molecule 2.23988
GGCT gamma-glutamylcyclotransferase 2.23005
CCDC169 coiled-coil domain containing 169 2.23005
C1D C1D nuclear receptor corepressor 2.22346
CAPS2 calcyphosine 2 2.22346
LRATD1 LRAT domain containing 1 2.20603
VCL vinculin 2.20496
KRTCAP2 keratinocyte associated protein 2 2.18589
RGMB repulsive guidance molecule family member b 2.14268
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein 2.11936
LMNB1 lamin B1 2.11936
RBM41 RNA binding motif protein 41 2.11885
EPOR erythropoietin receptor 2.118
USP34 ubiquitin specific peptidase 34 2.11406
KLF8 Kruppel-like factor 8 2.09639
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 2.08853
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 2.07325
TFCP2L1 transcription factor CP2-like 1 2.04569
SYCE1L synaptonemal complex central element protein 1-like 2.02926
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa 2.0044

decreased expression

Symbol Name Standardized Value
CASP8 caspase 8, apoptosis-related cysteine peptidase -3.68427
MRPL53 mitochondrial ribosomal protein L53 -3.68427
ZGLP1 zinc finger, GATA-like protein 1 -3.68427
CCDC110 coiled-coil domain containing 110 -3.68427
RHCE Rh blood group, CcEe antigens -3.68427
CFAP119 cilia and flagella associated protein 119 -3.68427
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -3.54357
SSPN sarcospan -3.54357
SGK2 serum/glucocorticoid regulated kinase 2 -3.54357
PPP1R37 protein phosphatase 1, regulatory subunit 37 -3.54357
POTEI POTE ankyrin domain family, member I -3.54357
IL1R1 interleukin 1 receptor, type I -3.54357
GIPC3 GIPC PDZ domain containing family, member 3 -3.54357
NR4A3 nuclear receptor subfamily 4, group A, member 3 -3.54357
MYH15 myosin, heavy chain 15 -3.54357
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) -3.54357
FAM3D family with sequence similarity 3, member D -3.54357
SNPH syntaphilin -3.54357
SCGN secretagogin, EF-hand calcium binding protein -3.54357
SH2D7 SH2 domain containing 7 -3.54357
IGFL4 IGF-like family member 4 -3.54357
LRRC43 leucine rich repeat containing 43 -3.54357
ASIC4 acid sensing (proton gated) ion channel family member 4 -3.54357
KLB klotho beta -3.54357
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 -3.54357
SFTA2 surfactant associated 2 -3.54357
RGCC regulator of cell cycle -3.54357
CCN3 cellular communication network factor 3 -3.54357
GSTT4 glutathione S-transferase theta 4 -3.54357
AMN amnion associated transmembrane protein -3.54357
TMEM272 transmembrane protein 272 -3.54357
H3C13 H3 clustered histone 13 -3.54357
CAMK2B calcium/calmodulin-dependent protein kinase II beta -3.54357
AK5 adenylate kinase 5 -3.54357
AQP3 aquaporin 3 (Gill blood group) -3.54357
CH25H cholesterol 25-hydroxylase -3.54357
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 -3.54357
LCT lactase -3.54357
PNKP polynucleotide kinase 3'-phosphatase -3.42726
LRRC9 leucine rich repeat containing 9 -3.3355
ZNF691 zinc finger protein 691 -3.20202
LXN latexin -3.10911
CLYBL citrate lyase beta like -3.00108
FEZ1 fasciculation and elongation protein zeta 1 (zygin I) -2.88565
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor -2.85627
CKAP2L cytoskeleton associated protein 2-like -2.8193
IL17RC interleukin 17 receptor C -2.8095
JPT1 Jupiter microtubule associated homolog 1 -2.78291
PRR7 proline rich 7 (synaptic) -2.6787
AMDHD2 amidohydrolase domain containing 2 -2.67216
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 -2.58672
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 -2.58672
CD7 CD7 molecule -2.58672
TTC8 tetratricopeptide repeat domain 8 -2.49229
AEBP1 AE binding protein 1 -2.4737
PTGIS prostaglandin I2 (prostacyclin) synthase -2.45834
SMOC1 SPARC related modular calcium binding 1 -2.41211
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -2.41211
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3 -2.40283
MYCBPAP MYCBP associated protein -2.36324
MFGE8 milk fat globule-EGF factor 8 protein -2.31856
DCLRE1C DNA cross-link repair 1C -2.31226
THYN1 thymocyte nuclear protein 1 -2.31094
DNAAF4 dynein axonemal assembly factor 4 -2.2897
ATOX1 antioxidant 1 copper chaperone -2.27456
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 -2.27321
KDM2B lysine (K)-specific demethylase 2B -2.27321
MMP25 matrix metallopeptidase 25 -2.26363
IQCK IQ motif containing K -2.23005
ZC3H12A zinc finger CCCH-type containing 12A -2.23005
OVGP1 oviductal glycoprotein 1, 120kDa -2.23005
TMEM38A transmembrane protein 38A -2.23005
CD63 CD63 molecule -2.20496
SPMIP6 sperm microtubule inner protein 6 -2.20362
DNAI3 dynein axonemal intermediate chain 3 -2.1707
CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2 -2.1707
ADAP1 ArfGAP with dual PH domains 1 -2.16464
TNXB tenascin XB -2.15519
INTS7 integrator complex subunit 7 -2.14546
SACK1H scaffolding CK1 anchoring protein H -2.09139
ZNF589 zinc finger protein 589 -2.08716
LARGE2 LARGE xylosyl- and glucuronyltransferase 2 -2.03413
ABHD17A abhydrolase domain containing 17A -2.03094
FANCF Fanconi anemia, complementation group F -2.02926
CALCRL calcitonin receptor-like -2.02926
MEIS3 Meis homeobox 3 -2.02559
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 -2.01365
ALDOC aldolase C, fructose-bisphosphate -2.00319
YPEL3 yippee-like 3 (Drosophila) -2.00243