PRKCD Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description protein kinase C, delta|Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5580)
External Link http://www.ncbi.nlm.nih.gov/gene/5580
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171 interacting proteins for hub protein PRKCD from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACTA1 actin, alpha 1, skeletal muscle
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTB actin, beta
ACTG1 actin gamma 1
ADAM17 ADAM metallopeptidase domain 17
ADAM9 ADAM metallopeptidase domain 9
ADCY7 adenylate cyclase 7
ADD1 adducin 1 (alpha)
ADD2 adducin 2 (beta)
ADRA2A adrenoceptor alpha 2A
ADRB2 adrenoceptor beta 2, surface
ADRBK1 adrenergic, beta, receptor kinase 1
AFAP1 actin filament associated protein 1
AICDA activation-induced cytidine deaminase
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT3 v-akt murine thymoma viral oncogene homolog 3
BDKRB2 bradykinin receptor B2
BEST1 bestrophin 1
C1QBP complement component 1, q subcomponent binding protein
C5AR1 complement component 5a receptor 1
CD34 CD34 molecule
CDCP1 CUB domain containing protein 1
CHAT choline O-acetyltransferase
CHN2 chimerin 2
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CREBBP CREB binding protein
CXCR4 chemokine (C-X-C motif) receptor 4
CYBA cytochrome b-245, alpha polypeptide
CYTH1 cytohesin 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAP3 death associated protein 3
DNM1L dynamin 1-like
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EGFR epidermal growth factor receptor
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
ELAVL1 ELAV like RNA binding protein 1
EP300 E1A binding protein p300
ESRRA estrogen-related receptor alpha
F11R F11 receptor
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FSCN1 fascin actin-bundling protein 1
FYN FYN proto-oncogene, Src family tyrosine kinase
G6PD glucose-6-phosphate dehydrogenase
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1
GAP43 growth associated protein 43
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GRM5 glutamate receptor, metabotropic 5
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
HABP4 hyaluronan binding protein 4
HDAC5 histone deacetylase 5
HIST1H2BN histone cluster 1, H2bn
HIST1H3A histone cluster 1, H3a
HNRNPK heterogeneous nuclear ribonucleoprotein K
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPB1 heat shock 27kDa protein 1
HVCN1 hydrogen voltage gated channel 1
IGF1R insulin-like growth factor 1 receptor
IGSF5 immunoglobulin superfamily, member 5
IL6ST interleukin 6 signal transducer
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
ITGA6 integrin, alpha 6
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB4 integrin, beta 4
ITGB7 integrin, beta 7
JAM2 junctional adhesion molecule 2
JAM3 junctional adhesion molecule 3
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4
KLF5 Kruppel-like factor 5 (intestinal)
KRT8 keratin 8, type II
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LDB3 LIM domain binding 3
LIMK2 LIM domain kinase 2
LMNB1 lamin B1
LMNB2 lamin B2
LYN LYN proto-oncogene, Src family tyrosine kinase
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPT microtubule-associated protein tau
MBP myelin basic protein
MEP1B meprin A, beta
MET MET proto-oncogene, receptor tyrosine kinase
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC1 mucin 1, cell surface associated
MYBPC3 myosin binding protein C, cardiac
NCF1 neutrophil cytosolic factor 1
NCF4 neutrophil cytosolic factor 4, 40kDa
NFE2L2 nuclear factor, erythroid 2-like 2
NUMB numb homolog (Drosophila)
OPRD1 opioid receptor, delta 1
PA2G4 proliferation-associated 2G4, 38kDa
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2
PDPK1 3-phosphoinositide dependent protein kinase 1
PEBP1 phosphatidylethanolamine binding protein 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLD2 phospholipase D2
PLSCR1 phospholipid scramblase 1
PLSCR3 phospholipid scramblase 3
PPARA peroxisome proliferator-activated receptor alpha
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PRKCZ protein kinase C, zeta
PRKD1 protein kinase D1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTK2B protein tyrosine kinase 2 beta
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRA protein tyrosine phosphatase, receptor type, A
PXN paxillin
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RHOA ras homolog family member A
RIPK4 receptor-interacting serine-threonine kinase 4
RPS3 ribosomal protein S3
RPS6 ribosomal protein S6
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RUNX2 runt-related transcription factor 2
SCRIB scribbled planar cell polarity protein
SDC4 syndecan 4
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
TAGLN transgelin
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TJP1 tight junction protein 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNNI3 troponin I type 3 (cardiac)
TP53 tumor protein p53
TP73 tumor protein p73
TRAF2 TNF receptor-associated factor 2
TRIM28 tripartite motif containing 28
TRIM41 tripartite motif containing 41
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TRPV4 transient receptor potential cation channel, subfamily V, member 4
VRK1 vaccinia related kinase 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta