PRKCD Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description protein kinase C, delta|Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5580)
External Link http://www.ncbi.nlm.nih.gov/gene/5580
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Genes

79 substrates of the kinase PRKCD from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
ADD1 adducin 1 (alpha)
AICDA activation-induced cytidine deaminase
BAG3 BCL2-associated athanogene 3
BEST1 bestrophin 1
BLVRA biliverdin reductase A
C5AR1 complement component 5a receptor 1
CARD9 caspase recruitment domain family, member 9
CAT catalase
CHAT choline O-acetyltransferase
CHN2 chimerin 2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCR4 chemokine (C-X-C motif) receptor 4
CYBA cytochrome b-245, alpha polypeptide
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAP3 death associated protein 3
DNM1L dynamin 1-like
ELAVL1 ELAV like RNA binding protein 1
ENOX2 ecto-NOX disulfide-thiol exchanger 2
EP300 E1A binding protein p300
FLI1 Fli-1 proto-oncogene, ETS transcription factor
G6PD glucose-6-phosphate dehydrogenase
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
HDAC5 histone deacetylase 5
HIST1H2BN histone cluster 1, H2bn
HIST1H3A histone cluster 1, H3a
HNRNPK heterogeneous nuclear ribonucleoprotein K
HSPB1 heat shock 27kDa protein 1
HVCN1 hydrogen voltage gated channel 1
IL6ST interleukin 6 signal transducer
IRS1 insulin receptor substrate 1
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KRT8 keratin 8, type II
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LIMK2 LIM domain kinase 2
MAPK8 mitogen-activated protein kinase 8
MET MET proto-oncogene, receptor tyrosine kinase
MUC1 mucin 1, cell surface associated
MYBPC3 myosin binding protein C, cardiac
NCF1 neutrophil cytosolic factor 1
NCF4 neutrophil cytosolic factor 4, 40kDa
NFE2L2 nuclear factor, erythroid 2-like 2
NLRC4 NLR family, CARD domain containing 4
NR2F6 nuclear receptor subfamily 2, group F, member 6
PA2G4 proliferation-associated 2G4, 38kDa
PEBP1 phosphatidylethanolamine binding protein 1
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLD2 phospholipase D2
PLSCR3 phospholipid scramblase 3
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PRKCD protein kinase C, delta
PRKD1 protein kinase D1
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRA protein tyrosine phosphatase, receptor type, A
PXN paxillin
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RPS3 ribosomal protein S3
RPS6 ribosomal protein S6
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RUNX2 runt-related transcription factor 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TNNI3 troponin I type 3 (cardiac)
TP53 tumor protein p53
TP73 tumor protein p73
TRIM28 tripartite motif containing 28
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TRPV4 transient receptor potential cation channel, subfamily V, member 4
VRK1 vaccinia related kinase 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta