PRKCE Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description protein kinase C, epsilon|Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5581)
External Link http://www.ncbi.nlm.nih.gov/gene/5581
Similar Terms
Downloads & Tools

Genes

200 interacting proteins for PRKCE from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
ACTC1 actin, alpha, cardiac muscle 1
ADAM17 ADAM metallopeptidase domain 17
ADAP1 ArfGAP with dual PH domains 1
ADCY1 adenylate cyclase 1 (brain)
ADCY2 adenylate cyclase 2 (brain)
ADCY3 adenylate cyclase 3
ADCY4 adenylate cyclase 4
ADCY5 adenylate cyclase 5
ADCY6 adenylate cyclase 6
ADCY7 adenylate cyclase 7
ADCY8 adenylate cyclase 8 (brain)
ADCY9 adenylate cyclase 9
AFAP1 actin filament associated protein 1
AKAP9 A kinase (PRKA) anchor protein 9
ARAF A-Raf proto-oncogene, serine/threonine kinase
ATF2 activating transcription factor 2
BAD BCL2-associated agonist of cell death
BAX BCL2-associated X protein
BCAR1 breast cancer anti-estrogen resistance 1
BRAF B-Raf proto-oncogene, serine/threonine kinase
BTK Bruton agammaglobulinemia tyrosine kinase
CABIN1 calcineurin binding protein 1
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHAT choline O-acetyltransferase
CHRM1 cholinergic receptor, muscarinic 1
CHRM2 cholinergic receptor, muscarinic 2
CHRM3 cholinergic receptor, muscarinic 3
CHRM4 cholinergic receptor, muscarinic 4
CHRM5 cholinergic receptor, muscarinic 5
CHUK conserved helix-loop-helix ubiquitous kinase
CNN1 calponin 1, basic, smooth muscle
COPB1 coatomer protein complex, subunit beta 1
COPB2 coatomer protein complex, subunit beta 2 (beta prime)
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CREB1 cAMP responsive element binding protein 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTNND1 catenin (cadherin-associated protein), delta 1
DAB2IP DAB2 interacting protein
DSP desmoplakin
EGFR epidermal growth factor receptor
ELAVL1 ELAV like RNA binding protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FRS2 fibroblast growth factor receptor substrate 2
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
GAB3 GRB2-associated binding protein 3
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GJA1 gap junction protein, alpha 1, 43kDa
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GRAP GRB2-related adaptor protein
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
GRM5 glutamate receptor, metabotropic 5
GSK3B glycogen synthase kinase 3 beta
HIST1H1A histone cluster 1, H1a
HK2 hexokinase 2
HNF4A hepatocyte nuclear factor 4, alpha
HRAS Harvey rat sarcoma viral oncogene homolog
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase
IGF1 insulin-like growth factor 1 (somatomedin C)
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL2 interleukin 2
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IQGAP1 IQ motif containing GTPase activating protein 1
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB5 integrin, beta 5
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JAK1 Janus kinase 1
JAK3 Janus kinase 3
KAT5 K(lysine) acetyltransferase 5
KEAP1 kelch-like ECH-associated protein 1
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT1 keratin 1, type II
KRT18 keratin 18, type I
KRT8 keratin 8, type II
LCK LCK proto-oncogene, Src family tyrosine kinase
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPK1 mitogen-activated protein kinase 1
MAPK11 mitogen-activated protein kinase 11
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPT microtubule-associated protein tau
MARK2 MAP/microtubule affinity-regulating kinase 2
MET MET proto-oncogene, receptor tyrosine kinase
MYH2 myosin, heavy chain 2, skeletal muscle, adult
MYH9 myosin, heavy chain 9, non-muscle
NF1 neurofibromin 1
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NREP neuronal regeneration related protein
NUMB numb homolog (Drosophila)
OCLN occludin
OPRD1 opioid receptor, delta 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PDLIM5 PDZ and LIM domain 5
PDPK1 3-phosphoinositide dependent protein kinase 1
PEBP1 phosphatidylethanolamine binding protein 1
PEBP4 phosphatidylethanolamine-binding protein 4
PECAM1 platelet/endothelial cell adhesion molecule 1
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PKM pyruvate kinase, muscle
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLD1 phospholipase D1, phosphatidylcholine-specific
PLD2 phospholipase D2
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A
PRKCA protein kinase C, alpha
PRKD1 protein kinase D1
PRKD2 protein kinase D2
PTK2B protein tyrosine kinase 2 beta
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAB11A RAB11A, member RAS oncogene family
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RASA2 RAS p21 protein activator 2
RASA4 RAS p21 protein activator 4
RASA4B RAS p21 protein activator 4B
RASAL2 RAS protein activator like 2
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
SDC4 syndecan 4
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC2 SHC (Src homology 2 domain containing) transforming protein 2
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SPHK1 sphingosine kinase 1
SPHK2 sphingosine kinase 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TBXA2R thromboxane A2 receptor
TIAM1 T-cell lymphoma invasion and metastasis 1
TICAM2 toll-like receptor adaptor molecule 2
TNNI3 troponin I type 3 (cardiac)
TP53 tumor protein p53
TRADD TNFRSF1A-associated via death domain
TRAF2 TNF receptor-associated factor 2
TRPV1 transient receptor potential cation channel, subfamily V, member 1
UBC ubiquitin C
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7
VDAC1 voltage-dependent anion channel 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta