PRKCE Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description protein kinase C, epsilon|Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5581)
External Link http://www.ncbi.nlm.nih.gov/gene/5581
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Genes

43 substrates of the kinase PRKCE from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
ADAP1 ArfGAP with dual PH domains 1
AICDA activation-induced cytidine deaminase
ATF2 activating transcription factor 2
BAD BCL2-associated agonist of cell death
CHAT choline O-acetyltransferase
CREB1 cAMP responsive element binding protein 1
CTNND1 catenin (cadherin-associated protein), delta 1
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGFR1 fibroblast growth factor receptor 1
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GJA1 gap junction protein, alpha 1, 43kDa
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IQGAP1 IQ motif containing GTPase activating protein 1
IRS1 insulin receptor substrate 1
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KCNK3 potassium channel, two pore domain subfamily K, member 3
KEAP1 kelch-like ECH-associated protein 1
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KRT18 keratin 18, type I
MAPT microtubule-associated protein tau
MET MET proto-oncogene, receptor tyrosine kinase
MYBPC3 myosin binding protein C, cardiac
NANOG Nanog homeobox
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
NSF N-ethylmaleimide-sensitive factor
OCLN occludin
OPRM1 opioid receptor, mu 1
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A
PRKCE protein kinase C, epsilon
PRKD1 protein kinase D1
PRKD2 protein kinase D2
RAB11A RAB11A, member RAS oncogene family
RAB5A RAB5A, member RAS oncogene family
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TICAM2 toll-like receptor adaptor molecule 2
TJP1 tight junction protein 1
TNNI3 troponin I type 3 (cardiac)
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7