PRKCH Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description protein kinase C, eta|Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5583)
External Link http://www.ncbi.nlm.nih.gov/gene/5583
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Genes

9 substrates of the kinase PRKCH from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
AICDA activation-induced cytidine deaminase
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GSTP1 glutathione S-transferase pi 1
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
PRKCH protein kinase C, eta
PRKD1 protein kinase D1
PRKD2 protein kinase D2
PTPN11 protein tyrosine phosphatase, non-receptor type 11