PRKCZ Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description protein kinase C, zeta|Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5590)
External Link http://www.ncbi.nlm.nih.gov/gene/5590
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Genes

45 substrates of the kinase PRKCZ from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
ADD1 adducin 1 (alpha)
ADD2 adducin 2 (beta)
AICDA activation-induced cytidine deaminase
AQP9 aquaporin 9
BAX BCL2-associated X protein
CABP4 calcium binding protein 4
CASP9 caspase 9, apoptosis-related cysteine peptidase
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CHAT choline O-acetyltransferase
CREBBP CREB binding protein
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
F11R F11 receptor
GEM GTP binding protein overexpressed in skeletal muscle
HABP4 hyaluronan binding protein 4
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IRS1 insulin receptor substrate 1
MAPK7 mitogen-activated protein kinase 7
MAPT microtubule-associated protein tau
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK3 MAP/microtubule affinity-regulating kinase 3
MYH10 myosin, heavy chain 10, non-muscle
NCF1 neutrophil cytosolic factor 1
NCOA3 nuclear receptor coactivator 3
NOTCH1 notch 1
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR1H4 nuclear receptor subfamily 1, group H, member 4
NREP neuronal regeneration related protein
NUMB numb homolog (Drosophila)
OCLN occludin
PHGDH phosphoglycerate dehydrogenase
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A
PRKCZ protein kinase C, zeta
PRKD1 protein kinase D1
PTEN phosphatase and tensin homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RND3 Rho family GTPase 3
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SP1 Sp1 transcription factor
STK11 serine/threonine kinase 11
TBC1D4 TBC1 domain family, member 4
TRAF2 TNF receptor-associated factor 2
WWC1 WW and C2 domain containing 1
YAP1 Yes-associated protein 1