PRKD2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description protein kinase D2|The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 25865)
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Genes

368 genes differentially expressed following the PRKD2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CIROZ ciliated left-right organizer protein containing ZP-N domains 2.27098
HTD2 hydroxyacyl-thioester dehydratase type 2 2.27098
ANKRD55 ankyrin repeat domain 55 2.27098
PRSS33 protease, serine, 33 2.27098
OR56A4 olfactory receptor, family 56, subfamily A, member 4 2.27098
HAO2 hydroxyacid oxidase 2 (long chain) 2.27098
RALB v-ral simian leukemia viral oncogene homolog B 2.27098
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 2.27098
APOC4 apolipoprotein C-IV 2.27098
GLOD5 glyoxalase domain containing 5 2.27098
AGTR1 angiotensin II receptor, type 1 2.27098
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 2.27098
DEPP1 DEPP autophagy regulator 1 2.27098
SLC26A4 solute carrier family 26 (anion exchanger), member 4 2.27098
SH2D6 SH2 domain containing 6 2.27098
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 2.27098
SEPTIN12 septin 12 2.27098
PRAP1 proline-rich acidic protein 1 2.27098
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.27098
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 2.27098
OTP orthopedia homeobox 2.27098
PCDHAC2 protocadherin alpha subfamily C, 2 2.27098
NPSR1 neuropeptide S receptor 1 2.27098
GSTP1 glutathione S-transferase pi 1 2.27098
FAT3 FAT atypical cadherin 3 2.27098
STK32C serine/threonine kinase 32C 2.2662
ASB15 ankyrin repeat and SOCS box containing 15 2.24307
TM4SF20 transmembrane 4 L six family member 20 2.24307
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) 2.24307
GRXCR2 glutaredoxin, cysteine rich 2 2.24307
UNC13C unc-13 homolog C (C. elegans) 2.24307
GPR158 G protein-coupled receptor 158 2.24307
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.24307
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 2.24307
FAM180B family with sequence similarity 180, member B 2.24307
ZNF492 zinc finger protein 492 2.24307
CELF3 CUGBP, Elav-like family member 3 2.24307
TSGA13 testis specific, 13 2.24307
CD1C CD1c molecule 2.24307
GAL galanin/GMAP prepropeptide 2.24307
TNNI1 troponin I type 1 (skeletal, slow) 2.24307
RAB17 RAB17, member RAS oncogene family 2.24307
HES3 hes family bHLH transcription factor 3 2.24307
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2.24307
CELA1 chymotrypsin-like elastase family, member 1 2.24307
CRX cone-rod homeobox 2.24307
CPSF2 cleavage and polyadenylation specific factor 2, 100kDa 2.24307
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa 2.24307
EIF1 eukaryotic translation initiation factor 1 2.24307
OR5V1 olfactory receptor, family 5, subfamily V, member 1 2.24307
C1GALT1C1L C1GALT1-specific chaperone 1 like 2.24307
LRRC61 leucine rich repeat containing 61 2.24307
RFX6 regulatory factor X, 6 2.24307
BFSP2 beaded filament structural protein 2, phakinin 2.24307
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 2.24307
SPP1 secreted phosphoprotein 1 2.24307
RGPD3 RANBP2-like and GRIP domain containing 3 2.24307
NEU4 sialidase 4 2.24307
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.24307
MFAP5 microfibrillar associated protein 5 2.24307
NAGS N-acetylglutamate synthase 2.24307
TRIM77 tripartite motif containing 77 2.24307
RFPL3 ret finger protein-like 3 2.24307
OTUD6A OTU deubiquitinase 6A 2.24307
RAPSN receptor-associated protein of the synapse 2.24307
BSX brain-specific homeobox 2.24307
PRDM16 PR domain containing 16 2.24307
CD274 CD274 molecule 2.24307
CIMAP1D CIMAP1 family member D 2.24307
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 2.24307
SATB1 SATB homeobox 1 2.24307
KRT80 keratin 80, type II 2.24307
OR6F1 olfactory receptor, family 6, subfamily F, member 1 2.24307
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 2.24307
LRTM3 leucine rich repeat transmembrane protein 3 2.24307
TMEM40 transmembrane protein 40 2.24307
ASB5 ankyrin repeat and SOCS box containing 5 2.24307
RDH8 retinol dehydrogenase 8 (all-trans) 2.24307
BDKRB1 bradykinin receptor B1 2.24307
MIOX myo-inositol oxygenase 2.24307
CLDN16 claudin 16 2.24307
GPX6 glutathione peroxidase 6 2.24307
CFAP206 cilia and flagella associated protein 206 2.24307
GARIN1A golgi associated RAB2 interactor 1A 2.24307
BRME1 break repair meiotic recombinase recruitment factor 1 2.24307
PLPP4 phospholipid phosphatase 4 2.24307
PLAAT2 phospholipase A and acyltransferase 2 2.24307
CCN6 cellular communication network factor 6 2.24307
ASDURF ASNSD1 upstream open reading frame 2.24307
DERPC DERPC proline and glycine rich nuclear protein 2.24307
TTLL13 tubulin tyrosine ligase like 13 2.24307
ALPG alkaline phosphatase, germ cell 2.24307
C3AR1 complement component 3a receptor 1 2.24307
DOK2 docking protein 2, 56kDa 2.24307
LTF lactotransferrin 2.24307
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 2.24307
C4ORF17 chromosome 4 open reading frame 17 2.24307
PTPRH protein tyrosine phosphatase, receptor type, H 2.24307
ZNF436 zinc finger protein 436 2.24307
TMEM229B transmembrane protein 229B 2.24307
ATP13A5 ATPase type 13A5 2.24307
GUCA1C guanylate cyclase activator 1C 2.24307
LOX lysyl oxidase 2.24307
CFHR3 complement factor H-related 3 2.24307
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa 2.24307
FAM187B family with sequence similarity 187, member B 2.24307
NXPE2 neurexophilin and PC-esterase domain family, member 2 2.24307
ZIC4 Zic family member 4 2.24307
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.24307
SAMD11 sterile alpha motif domain containing 11 2.24307
BLNK B-cell linker 2.24307
PGA3 pepsinogen 3, group I (pepsinogen A) 2.24307
ALG10B ALG10B, alpha-1,2-glucosyltransferase 2.24307
SASH3 SAM and SH3 domain containing 3 2.24307
TACR2 tachykinin receptor 2 2.24307
S100B S100 calcium binding protein B 2.24307
CFAP45 cilia and flagella associated protein 45 2.24307
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 2.24307
SIM2 single-minded family bHLH transcription factor 2 2.24307
DNM1L dynamin 1-like 2.24307
TBC1D21 TBC1 domain family, member 21 2.24307
NT5C1B 5'-nucleotidase, cytosolic IB 2.24307
NTN3 netrin 3 2.24307
EPHA2 EPH receptor A2 2.24307
ZC3H11D zinc finger CCCH-type containing 11D 2.24307
CH25H cholesterol 25-hydroxylase 2.24307
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 2.24307
KLK4 kallikrein-related peptidase 4 2.24307
CT55 cancer/testis antigen 55 2.24307
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) 2.24307
PENK proenkephalin 2.24307
ZNF366 zinc finger protein 366 2.24307
DAW1 dynein assembly factor with WDR repeat domains 1 2.24307
FZD1 frizzled class receptor 1 2.24307
MAPK11 mitogen-activated protein kinase 11 2.24307
TCF21 transcription factor 21 2.24307
MAGEB17 melanoma antigen family B17 2.24307
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 2.24307
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent) 2.24307
OR3A1 olfactory receptor, family 3, subfamily A, member 1 2.24307
TIGIT T cell immunoreceptor with Ig and ITIM domains 2.24307
CST1 cystatin SN 2.24307
DQX1 DEAQ box RNA-dependent ATPase 1 2.24307
SYNE3 spectrin repeat containing, nuclear envelope family member 3 2.24307
CAMTA1 calmodulin binding transcription activator 1 2.24307
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 2.24307
TRIM55 tripartite motif containing 55 2.24307
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 2.24307
IL19 interleukin 19 2.24307
CRHR1 corticotropin releasing hormone receptor 1 2.24307
ISL2 ISL LIM homeobox 2 2.24307
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 2.24307
MUCL1 mucin-like 1 2.24307
HOXD3 homeobox D3 2.24307
IL1B interleukin 1, beta 2.24307
SNCG synuclein, gamma (breast cancer-specific protein 1) 2.24307
ADORA3 adenosine A3 receptor 2.24307
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6 2.24307
LZTR1 leucine-zipper-like transcription regulator 1 2.24307
RETNLB resistin like beta 2.24307
HRCT1 histidine rich carboxyl terminus 1 2.24307
MPLKIP M-phase specific PLK1 interacting protein 2.24307
SCML4 sex comb on midleg-like 4 (Drosophila) 2.24307
HELT helt bHLH transcription factor 2.24307
WNT7B wingless-type MMTV integration site family, member 7B 2.24307
SLC39A12 solute carrier family 39 (zinc transporter), member 12 2.24307
IRX4 iroquois homeobox 4 2.24307
NLRP11 NLR family, pyrin domain containing 11 2.24307
NOG noggin 2.24307
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 2.24307
SFTA2 surfactant associated 2 2.24307
LMX1B LIM homeobox transcription factor 1, beta 2.24307
ANGPTL3 angiopoietin-like 3 2.24307
ETV3L ets variant 3-like 2.24307
PF4V1 platelet factor 4 variant 1 2.24307
APOA5 apolipoprotein A-V 2.24307
CD22 CD22 molecule 2.24307
GRM5 glutamate receptor, metabotropic 5 2.24307
HMX1 H6 family homeobox 1 2.24307
CCL25 chemokine (C-C motif) ligand 25 2.24307
CSNK2A3 casein kinase 2, alpha 3 polypeptide 2.24307
SPACA3 sperm acrosome associated 3 2.24307
ECHDC2 enoyl CoA hydratase domain containing 2 2.24307
GOLGA8J golgin A8 family, member J 2.24307
BTBD16 BTB (POZ) domain containing 16 2.24307
HRG histidine-rich glycoprotein 2.24307
TPH1 tryptophan hydroxylase 1 2.24307
PADI4 peptidyl arginine deiminase, type IV 2.24307
TGM6 transglutaminase 6 2.24307
AQP1 aquaporin 1 (Colton blood group) 2.24307
ANHX anomalous homeobox 2.24307
NPAS4 neuronal PAS domain protein 4 2.24307
USP17L7 ubiquitin specific peptidase 17-like family member 7 2.24307
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 2.24307
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.24307
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) 2.24307
IDI1 isopentenyl-diphosphate delta isomerase 1 2.24307
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 2.24307
TRPM8 transient receptor potential cation channel, subfamily M, member 8 2.24307
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 2.24307
IGIP IgA-inducing protein 2.24307
OR13G1 olfactory receptor, family 13, subfamily G, member 1 2.24307
PIAS2 protein inhibitor of activated STAT, 2 2.24307
SUN3 Sad1 and UNC84 domain containing 3 2.24307
AGBL1 ATP/GTP binding protein-like 1 2.24307
MYLK2 myosin light chain kinase 2 2.24307
MSLN mesothelin 2.24307
ANK2 ankyrin 2, neuronal 2.23122
HMOX1 heme oxygenase 1 2.22653
SALL4 spalt-like transcription factor 4 2.21158
RPS13 ribosomal protein S13 2.20199
TOE1 target of EGR1, member 1 (nuclear) 2.18418
POU2F1 POU class 2 homeobox 1 2.17602
HENMT1 HEN1 methyltransferase homolog 1 (Arabidopsis) 2.17182
ALOX15 arachidonate 15-lipoxygenase 2.15749
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase 2.13997
VARS1 valyl-tRNA synthetase 1 2.13731
MTDH metadherin 2.13731
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 2.13731
NTNG1 netrin G1 2.13731
PDZD2 PDZ domain containing 2 2.13355
ZNF844 zinc finger protein 844 2.13355
DUSP5 dual specificity phosphatase 5 2.13355
BPTF bromodomain PHD finger transcription factor 2.12708
CCR5AS CCR5 antisense RNA 2.1194
MRPS18B mitochondrial ribosomal protein S18B 2.1194
TRIM61 tripartite motif containing 61 2.11809
KBTBD12 kelch repeat and BTB (POZ) domain containing 12 2.11809
RPL14 ribosomal protein L14 2.11809
NCAPD3 non-SMC condensin II complex, subunit D3 2.11803
CNIH4 cornichon family AMPA receptor auxiliary protein 4 2.11803
FLAD1 flavin adenine dinucleotide synthetase 1 2.09801
FAM53B family with sequence similarity 53, member B 2.09801
P2RY1 purinergic receptor P2Y, G-protein coupled, 1 2.09689
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 2.09689
LHFPL5 lipoma HMGIC fusion partner-like 5 2.09689
CATSPER4 cation channel, sperm associated 4 2.09689
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa 2.09689
CINP cyclin-dependent kinase 2 interacting protein 2.09495
FCGBP Fc fragment of IgG binding protein 2.08004
ADA2 adenosine deaminase 2 2.07896
KCNK12 potassium channel, two pore domain subfamily K, member 12 2.06836
ACOX1 acyl-CoA oxidase 1, palmitoyl 2.0506
FERMT2 fermitin family member 2 2.03187
TMEM14C transmembrane protein 14C 2.01711
GEMIN6 gem (nuclear organelle) associated protein 6 2.01448
DAAM2 dishevelled associated activator of morphogenesis 2 2.01189
PPIA peptidylprolyl isomerase A (cyclophilin A) 2.01189
SIDT2 SID1 transmembrane family, member 2 2.01164
GCK glucokinase (hexokinase 4) 2.00885
METTL24 methyltransferase like 24 2.00481
TMEM102 transmembrane protein 102 2.00031
EHD1 EH-domain containing 1 2.00031

decreased expression

Symbol Name Standardized Value
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -2.27098
BOC BOC cell adhesion associated, oncogene regulated -2.27098
OXTR oxytocin receptor -2.27098
MRPS2 mitochondrial ribosomal protein S2 -2.27098
PKNOX1 PBX/knotted 1 homeobox 1 -2.27098
NEK1 NIMA-related kinase 1 -2.25928
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.24607
KAT6A K(lysine) acetyltransferase 6A -2.24307
MSL3 male-specific lethal 3 homolog (Drosophila) -2.24307
MMP16 matrix metallopeptidase 16 (membrane-inserted) -2.24307
RNF144A ring finger protein 144A -2.24307
SOX7 SRY (sex determining region Y)-box 7 -2.24307
ECM2 extracellular matrix protein 2, female organ and adipocyte specific -2.24307
ZNF385B zinc finger protein 385B -2.24307
CPE carboxypeptidase E -2.24307
SLC48A1 solute carrier family 48 (heme transporter), member 1 -2.24307
AS3MT arsenite methyltransferase -2.24307
NRG2 neuregulin 2 -2.24307
LUZP1 leucine zipper protein 1 -2.24307
PRSS12 protease, serine, 12 (neurotrypsin, motopsin) -2.24307
ZBTB9 zinc finger and BTB domain containing 9 -2.24307
CRB2 crumbs family member 2 -2.24307
PHRF1 PHD and ring finger domains 1 -2.24307
CEP19 centrosomal protein 19kDa -2.24307
TSC22D1 TSC22 domain family, member 1 -2.24307
CANT1 calcium activated nucleotidase 1 -2.24307
PHEX phosphate regulating endopeptidase homolog, X-linked -2.24307
CHD9 chromodomain helicase DNA binding protein 9 -2.24307
SDK1 sidekick cell adhesion molecule 1 -2.24307
FTSJ3 FtsJ homolog 3 (E. coli) -2.24307
MGAT4C MGAT4 family, member C -2.24307
C1ORF74 chromosome 1 open reading frame 74 -2.24307
ZNF83 zinc finger protein 83 -2.24307
RPL9 ribosomal protein L9 -2.24307
SMIM8 small integral membrane protein 8 -2.24307
PAXBP1 PAX3 and PAX7 binding protein 1 -2.24307
CADM2 cell adhesion molecule 2 -2.24307
MSRA methionine sulfoxide reductase A -2.24307
ATP5MC2 ATP synthase membrane subunit c locus 2 -2.24307
EHMT2 euchromatic histone-lysine N-methyltransferase 2 -2.24307
NTN4 netrin 4 -2.24307
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -2.24307
BNC2 basonuclin 2 -2.24307
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -2.24307
ZMYM1 zinc finger, MYM-type 1 -2.24014
TTF2 transcription termination factor, RNA polymerase II -2.24014
RGS19 regulator of G-protein signaling 19 -2.21197
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa -2.2036
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) -2.18858
PCBP1 poly(rC) binding protein 1 -2.18418
PCCA propionyl CoA carboxylase, alpha polypeptide -2.18418
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -2.18169
ATAD2B ATPase family, AAA domain containing 2B -2.18155
FAM163B family with sequence similarity 163, member B -2.16117
TTC13 tetratricopeptide repeat domain 13 -2.15749
STOX1 storkhead box 1 -2.15749
FAT2 FAT atypical cadherin 2 -2.13997
PODXL podocalyxin-like -2.13355
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) -2.13355
CDON cell adhesion associated, oncogene regulated -2.13355
MKX mohawk homeobox -2.12102
ZNF287 zinc finger protein 287 -2.12102
CPSF3 cleavage and polyadenylation specific factor 3, 73kDa -2.12102
ZNF517 zinc finger protein 517 -2.12102
ZNF337 zinc finger protein 337 -2.11803
IGBP1 immunoglobulin (CD79A) binding protein 1 -2.11249
STAT4 signal transducer and activator of transcription 4 -2.1095
CAPN7 calpain 7 -2.09801
ACTL8 actin-like 8 -2.09689
APP-DT APP divergent transcript -2.09689
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 -2.09689
TMEM238L transmembrane protein 238 like -2.09689
CAVIN4 caveolae associated protein 4 -2.09689
SYCP1 synaptonemal complex protein 1 -2.09689
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma -2.09689
GDF6 growth differentiation factor 6 -2.09689
H4C3 H4 clustered histone 3 -2.09689
UPK3B uroplakin 3B -2.09689
MOG myelin oligodendrocyte glycoprotein -2.09689
APOA1 apolipoprotein A-I -2.09689
KIF19 kinesin family member 19 -2.09689
SYTL3 synaptotagmin-like 3 -2.09689
PCDHGB1 protocadherin gamma subfamily B, 1 -2.09689
CERS3 ceramide synthase 3 -2.09689
QDPR quinoid dihydropteridine reductase -2.09689
ZNF540 zinc finger protein 540 -2.09689
FAM209A family with sequence similarity 209, member A -2.09689
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A -2.09689
ARL3 ADP-ribosylation factor-like 3 -2.09689
ZGLP1 zinc finger, GATA-like protein 1 -2.09689
RBM24 RNA binding motif protein 24 -2.09689
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 -2.09689
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) -2.09689
PTGER3 prostaglandin E receptor 3 (subtype EP3) -2.09689
PTCH2 patched 2 -2.09689
GPR22 G protein-coupled receptor 22 -2.09689
KCNIP3 Kv channel interacting protein 3, calsenilin -2.09689
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -2.09689
TMEM100 transmembrane protein 100 -2.09689
SPX spexin hormone -2.09689
MT1H metallothionein 1H -2.09643
PLAU plasminogen activator, urokinase -2.08004
CDK6 cyclin-dependent kinase 6 -2.06836
PID1 phosphotyrosine interaction domain containing 1 -2.03291
MALL mal, T-cell differentiation protein-like -2.03291
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 -2.02969
STMN3 stathmin-like 3 -2.02969
PNRC2 proline-rich nuclear receptor coactivator 2 -2.02969
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 -2.01608
TTYH3 tweety family member 3 -2.0154
NPIPB9 nuclear pore complex interacting protein family, member B9 -2.01448
FHIP1B FHF complex subunit HOOK interacting protein 1B -2.01365
CIT citron rho-interacting serine/threonine kinase -2.00605
ZNF423 zinc finger protein 423 -2.00031
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -2.00031