PRKDC Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description protein kinase, DNA-activated, catalytic polypeptide|This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010] (NCBI Entrez Gene Database, 5591)
External Link http://www.ncbi.nlm.nih.gov/gene/5591
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Genes

37 substrates of the kinase PRKDC from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
AIRE autoimmune regulator
AKT1 v-akt murine thymoma viral oncogene homolog 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CHEK2 checkpoint kinase 2
DCLRE1C DNA cross-link repair 1C
FUS FUS RNA binding protein
H2AFX H2A histone family, member X
HIST1H1C histone cluster 1, H1c
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IGFBP3 insulin-like growth factor binding protein 3
IRF3 interferon regulatory factor 3
LIG4 ligase IV, DNA, ATP-dependent
MED1 mediator complex subunit 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NHEJ1 nonhomologous end-joining factor 1
PDX1 pancreatic and duodenal homeobox 1
PNPT1 polyribonucleotide nucleotidyltransferase 1
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
POU2F1 POU class 2 homeobox 1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RAG2 recombination activating gene 2
RPA2 replication protein A2, 32kDa
SRF serum response factor (c-fos serum response element-binding transcription factor)
STK11 serine/threonine kinase 11
TDP1 tyrosyl-DNA phosphodiesterase 1
TP53 tumor protein p53
USF1 upstream transcription factor 1
VCP valosin containing protein
VIM vimentin
WRN Werner syndrome, RecQ helicase-like
XPA xeroderma pigmentosum, complementation group A
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZIC2 Zic family member 2