PRKG1 Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description protein kinase, cGMP-dependent, type I|Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011] (NCBI Entrez Gene Database, 5592)
External Link http://www.ncbi.nlm.nih.gov/gene/5592
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117 interacting proteins for hub protein PRKG1 from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADCY8 adenylate cyclase 8 (brain)
ADRB2 adrenoceptor beta 2, surface
AFAP1 actin filament associated protein 1
ANXA1 annexin A1
APC adenomatous polyposis coli
ARFGEF3 ARFGEF family member 3
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ATF2 activating transcription factor 2
AURKB aurora kinase B
AURKC aurora kinase C
BAD BCL2-associated agonist of cell death
BRAF B-Raf proto-oncogene, serine/threonine kinase
C1QA complement component 1, q subcomponent, A chain
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit
CAST calpastatin
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCNY cyclin Y
CD5 CD5 molecule
CENPA centromere protein A
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CGB chorionic gonadotropin, beta polypeptide
CHRND cholinergic receptor, nicotinic, delta (muscle)
CLMN calmin (calponin-like, transmembrane)
CLN3 ceroid-lipofuscinosis, neuronal 3
CREB1 cAMP responsive element binding protein 1
CRIP2 cysteine-rich protein 2
CRYAA crystallin, alpha A
CRYAB crystallin, alpha B
DCX doublecortin
DLGAP2 discs, large (Drosophila) homolog-associated protein 2
DNM1 dynamin 1
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
FGA fibrinogen alpha chain
FHOD1 formin homology 2 domain containing 1
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GFAP glial fibrillary acidic protein
GJB1 gap junction protein, beta 1, 32kDa
GKAP1 G kinase anchoring protein 1
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GTF2I general transcription factor IIi
H2AFX H2A histone family, member X
HRH1 histamine receptor H1
HSPB1 heat shock 27kDa protein 1
HSPB6 heat shock protein, alpha-crystallin-related, B6
INCENP inner centromere protein antigens 135/155kDa
IRF2BPL interferon regulatory factor 2 binding protein-like
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT19 keratin 19, type I
LASP1 LIM and SH3 protein 1
LATS1 large tumor suppressor kinase 1
LIPE lipase, hormone-sensitive
MAP1B microtubule-associated protein 1B
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPT microtubule-associated protein tau
MARK1 MAP/microtubule affinity-regulating kinase 1
MIP major intrinsic protein of lens fiber
MRVI1 murine retrovirus integration site 1 homolog
NCF1 neutrophil cytosolic factor 1
NELFB negative elongation factor complex member B
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NPR1 natriuretic peptide receptor 1
OSR1 odd-skipped related transciption factor 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PDE5A phosphodiesterase 5A, cGMP-specific
PDPK1 3-phosphoinositide dependent protein kinase 1
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
PHKG1 phosphorylase kinase, gamma 1 (muscle)
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEC plectin
PLK1 polo-like kinase 1
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A
PPP1R17 protein phosphatase 1, regulatory subunit 17
PRKCA protein kinase C, alpha
PRKG1 protein kinase, cGMP-dependent, type I
PRKG2 protein kinase, cGMP-dependent, type II
PTS 6-pyruvoyltetrahydropterin synthase
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAP1B RAP1B, member of RAS oncogene family
RAP1GAP2 RAP1 GTPase activating protein 2
RGS2 regulator of G-protein signaling 2
RHOA ras homolog family member A
RIMS2 regulating synaptic membrane exocytosis 2
RPS3P2 ribosomal protein S3 pseudogene 2
RYR1 ryanodine receptor 1 (skeletal)
RYR2 ryanodine receptor 2 (cardiac)
SEPT3 septin 3
SF1 splicing factor 1
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SON SON DNA binding protein
SPP1 secreted phosphoprotein 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SRF serum response factor (c-fos serum response element-binding transcription factor)
SRRM1 serine/arginine repetitive matrix 1
SRRM2 serine/arginine repetitive matrix 2
SRSF5 serine/arginine-rich splicing factor 5
SRSF7 serine/arginine-rich splicing factor 7
SSB Sjogren syndrome antigen B (autoantigen La)
SYN2 synapsin II
TBXA2R thromboxane A2 receptor
TERT telomerase reverse transcriptase
TNNT1 troponin T type 1 (skeletal, slow)
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TTN titin
UFL1 UFM1-specific ligase 1
VASP vasodilator-stimulated phosphoprotein
VIM vimentin
ZBTB7A zinc finger and BTB domain containing 7A