| Dataset | PhosphoSitePlus Substrates of Kinases |
| Category | physical interactions |
| Type | kinase |
| Description | protein kinase, cGMP-dependent, type I|Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011] (NCBI Entrez Gene Database, 5592) |
| External Link | http://www.ncbi.nlm.nih.gov/gene/5592 |
| Similar Terms | |
| Downloads & Tools |
30 substrates of the kinase PRKG1 from the curated PhosphoSitePlus Substrates of Kinases dataset.
| Symbol | Name |
|---|---|
| BAD | BCL2-associated agonist of cell death |
| CCDC80 | coiled-coil domain containing 80 |
| FHOD1 | formin homology 2 domain containing 1 |
| GABRB1 | gamma-aminobutyric acid (GABA) A receptor, beta 1 |
| GTF2I | general transcription factor IIi |
| HRH1 | histamine receptor H1 |
| HSPB1 | heat shock 27kDa protein 1 |
| HSPB6 | heat shock protein, alpha-crystallin-related, B6 |
| LASP1 | LIM and SH3 protein 1 |
| LIPE | lipase, hormone-sensitive |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 |
| PDE5A | phosphodiesterase 5A, cGMP-specific |
| PPP1R14A | protein phosphatase 1, regulatory (inhibitor) subunit 14A |
| PRKG1 | protein kinase, cGMP-dependent, type I |
| PTS | 6-pyruvoyltetrahydropterin synthase |
| RAP1B | RAP1B, member of RAS oncogene family |
| RAP1GAP2 | RAP1 GTPase activating protein 2 |
| RGS18 | regulator of G-protein signaling 18 |
| RGS2 | regulator of G-protein signaling 2 |
| RHOA | ras homolog family member A |
| RYR2 | ryanodine receptor 2 (cardiac) |
| SLC6A4 | solute carrier family 6 (neurotransmitter transporter), member 4 |
| SRF | serum response factor (c-fos serum response element-binding transcription factor) |
| SSB | Sjogren syndrome antigen B (autoantigen La) |
| TBXA2R | thromboxane A2 receptor |
| TRPC3 | transient receptor potential cation channel, subfamily C, member 3 |
| TRPC6 | transient receptor potential cation channel, subfamily C, member 6 |
| TRPC7 | transient receptor potential cation channel, subfamily C, member 7 |
| TTN | titin |
| VASP | vasodilator-stimulated phosphoprotein |
