PRNP Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description prion protein|The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] (NCBI Entrez Gene Database, 5621)
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Genes

355 genes differentially expressed following the PRNP gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PTPRH protein tyrosine phosphatase, receptor type, H 3.37635
NR1H4 nuclear receptor subfamily 1, group H, member 4 3.37635
CARD18 caspase recruitment domain family, member 18 3.37635
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 3.37635
SLC26A1 solute carrier family 26 (anion exchanger), member 1 3.37635
ADGRE1 adhesion G protein-coupled receptor E1 3.37635
DUXB double homeobox B 3.37635
BTN1A1 butyrophilin, subfamily 1, member A1 3.37635
PDYN prodynorphin 3.37635
BTLA B and T lymphocyte associated 3.37635
TM4SF1 transmembrane 4 L six family member 1 3.37635
HORMAD1 HORMA domain containing 1 3.37635
CHADL chondroadherin-like 3.37635
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 3.37635
NAPSA napsin A aspartic peptidase 3.37635
PTPRC protein tyrosine phosphatase, receptor type, C 3.37635
NKX2-6 NK2 homeobox 6 3.37635
SLFN14 schlafen family member 14 3.37635
SECTM1 secreted and transmembrane 1 3.37635
TBX20 T-box 20 3.37635
TBX21 T-box 21 3.37635
ZNF98 zinc finger protein 98 3.37635
SCARA5 scavenger receptor class A, member 5 3.37635
RHOXF2B Rhox homeobox family, member 2B 3.37635
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 3.37635
SPANXB1 SPANX family, member B1 3.37635
CNTNAP4 contactin associated protein-like 4 3.37635
CCNB3 cyclin B3 3.37635
S100A5 S100 calcium binding protein A5 3.37635
IL2RA interleukin 2 receptor, alpha 3.37635
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 3.37635
MYO16 myosin XVI 3.37635
LGALS4 lectin, galactoside-binding, soluble, 4 3.37635
MYO1G myosin IG 3.37635
OR4D9 olfactory receptor, family 4, subfamily D, member 9 3.37635
HMX2 H6 family homeobox 2 3.37635
MYL7 myosin, light chain 7, regulatory 3.37635
CDRT15 CMT1A duplicated region transcript 15 3.37635
NWD2 NACHT and WD repeat domain containing 2 3.37635
GNG13 guanine nucleotide binding protein (G protein), gamma 13 3.37635
FABP12 fatty acid binding protein 12 3.37635
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 3.37635
DUSP10 dual specificity phosphatase 10 3.37635
TKTL1 transketolase-like 1 3.37635
OLIG1 oligodendrocyte transcription factor 1 3.37635
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.37635
TUBB8 tubulin, beta 8 class VIII 3.37635
MUSK muscle, skeletal, receptor tyrosine kinase 3.37635
SPINT3 serine peptidase inhibitor, Kunitz type, 3 3.37635
GCKR glucokinase (hexokinase 4) regulator 3.37635
RAPSN receptor-associated protein of the synapse 3.37635
ADAMTSL5 ADAMTS-like 5 3.37635
RGPD3 RANBP2-like and GRIP domain containing 3 3.37635
SLC10A4 solute carrier family 10, member 4 3.37635
DMP1 dentin matrix acidic phosphoprotein 1 3.37635
OR1R1 olfactory receptor family 1 subfamily R member 1 3.37635
FKBP6 FK506 binding protein 6, 36kDa 3.37635
LTB4R2 leukotriene B4 receptor 2 3.37635
ADGRG3 adhesion G protein-coupled receptor G3 3.37635
CXCL13 chemokine (C-X-C motif) ligand 13 3.37635
BNC1 basonuclin 1 3.37635
SPRR2A small proline-rich protein 2A 3.37635
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 3.37635
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 3.37635
WDR64 WD repeat domain 64 3.37635
VSIG8 V-set and immunoglobulin domain containing 8 3.37635
ZNF705D zinc finger protein 705D 3.37635
ALDOB aldolase B, fructose-bisphosphate 3.37635
H1-6 H1.6 linker histone, cluster member 3.37635
VSIR V-set immunoregulatory receptor 3.37635
SPMIP9 sperm microtubule inner protein 9 3.37635
THSD8 thrombospondin type 1 domain containing 8 3.37635
DEFB109B defensin beta 109B 3.37635
MUCL3 mucin like 3 3.37635
CFAP299 cilia and flagella associated protein 299 3.37635
SPDYE9 speedy/RINGO cell cycle regulator family member E9 3.37635
CBLIF cobalamin binding intrinsic factor 3.37635
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 3.37635
CCN6 cellular communication network factor 6 3.37635
TOMT transmembrane O-methyltransferase 3.37635
ANGPTL8 angiopoietin like 8 3.37635
OR7D2 olfactory receptor, family 7, subfamily D, member 2 3.37635
SYT15 synaptotagmin XV 3.37635
C1QTNF7 C1q and tumor necrosis factor related protein 7 3.37635
SLAMF6 SLAM family member 6 3.37635
MYH13 myosin, heavy chain 13, skeletal muscle 3.37635
ADGRG1 adhesion G protein-coupled receptor G1 3.37635
SIM2 single-minded family bHLH transcription factor 2 3.37635
MSX1 msh homeobox 1 3.37635
CATSPER3 cation channel, sperm associated 3 3.37635
SCN10A sodium channel, voltage gated, type X alpha subunit 3.37635
AXDND1 axonemal dynein light chain domain containing 1 3.37635
TSGA10IP testis specific, 10 interacting protein 3.37635
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 3.37635
OR2L2 olfactory receptor, family 2, subfamily L, member 2 3.37635
PRR4 proline rich 4 (lacrimal) 3.37635
CCR8 chemokine (C-C motif) receptor 8 3.37635
PRG4 proteoglycan 4 3.37635
ACE2 angiotensin I converting enzyme 2 3.37635
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 3.37635
FGFBP1 fibroblast growth factor binding protein 1 3.37635
STARD6 StAR-related lipid transfer (START) domain containing 6 3.37635
IL1R1 interleukin 1 receptor, type I 3.37635
PGA5 pepsinogen 5, group I (pepsinogen A) 3.37635
ALG10B ALG10B, alpha-1,2-glucosyltransferase 3.37635
SAA1 serum amyloid A1 3.37635
CELA2A chymotrypsin-like elastase family, member 2A 3.37635
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 3.37635
CFAP99 cilia and flagella associated protein 99 3.37635
EPO erythropoietin 3.37635
TBX1 T-box 1 3.37635
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 3.37635
ZFP92 ZFP92 zinc finger protein 3.37635
APOB apolipoprotein B 3.37635
VAX2 ventral anterior homeobox 2 3.37635
LRRK2 leucine-rich repeat kinase 2 3.37635
IL11 interleukin 11 3.37635
ALOXE3 arachidonate lipoxygenase 3 3.37635
GFI1B growth factor independent 1B transcription repressor 3.37635
SMIM22 small integral membrane protein 22 3.37635
CPZ carboxypeptidase Z 3.37635
MOS v-mos Moloney murine sarcoma viral oncogene homolog 3.37635
PRR15L proline rich 15-like 3.37635
NTSR1 neurotensin receptor 1 (high affinity) 3.37635
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 3.37635
SPTBN5 spectrin, beta, non-erythrocytic 5 3.37635
DMTN dematin actin binding protein 3.37635
FCN3 ficolin (collagen/fibrinogen domain containing) 3 3.37635
ANKRD55 ankyrin repeat domain 55 3.37635
BEAN1 brain expressed, associated with NEDD4, 1 3.37635
MYF5 myogenic factor 5 3.37635
AKR1B15 aldo-keto reductase family 1, member B15 3.37635
CDHR4 cadherin-related family member 4 3.37635
TTBK1 tau tubulin kinase 1 3.37635
SCML4 sex comb on midleg-like 4 (Drosophila) 3.37635
RNASE11 ribonuclease, RNase A family, 11 (non-active) 3.37635
PRM1 protamine 1 3.37635
PCDHGA2 protocadherin gamma subfamily A, 2 3.37635
EMP1 epithelial membrane protein 1 3.37635
ADAM2 ADAM metallopeptidase domain 2 3.37635
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 3.37635
GLOD5 glyoxalase domain containing 5 3.37635
ANKRD61 ankyrin repeat domain 61 3.37635
RSAD2 radical S-adenosyl methionine domain containing 2 3.37635
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 3.37635
POF1B premature ovarian failure, 1B 3.37635
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 3.37635
RAD51AP2 RAD51 associated protein 2 3.37635
GPR12 G protein-coupled receptor 12 3.37635
GRK1 G protein-coupled receptor kinase 1 3.37635
THTPA thiamine triphosphatase 3.37635
AQP7 aquaporin 7 3.37635
PSKH2 protein serine kinase H2 3.37635
ORM2 orosomucoid 2 3.37635
IRX5 iroquois homeobox 5 3.37635
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 3.37635
PPP1R3C protein phosphatase 1, regulatory subunit 3C 3.37635
PF4V1 platelet factor 4 variant 1 3.37635
GBX2 gastrulation brain homeobox 2 3.37635
OTP orthopedia homeobox 3.37635
ANXA1 annexin A1 3.37635
LKAAEAR1 LKAAEAR motif containing 1 3.37635
ANXA8 annexin A8 3.37635
SHBG sex hormone-binding globulin 3.37635
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 3.37635
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 3.37635
TMEM215 transmembrane protein 215 3.37635
ART1 ADP-ribosyltransferase 1 3.37635
MEIOB meiosis specific with OB domains 3.37635
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 3.37635
ASCL5 achaete-scute family bHLH transcription factor 5 3.37635
IFNK interferon, kappa 3.37635
APOA1 apolipoprotein A-I 3.37635
PLA2G2D phospholipase A2, group IID 3.37635
GFY golgi-associated, olfactory signaling regulator 3.37635
DAND5 DAN domain family member 5, BMP antagonist 3.37635
PATE2 prostate and testis expressed 2 3.37635
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 3.37635
OR6J1 olfactory receptor, family 6, subfamily J, member 1 (gene/pseudogene) 3.37635
CLCA4 chloride channel accessory 4 3.37635
APOL3 apolipoprotein L, 3 3.37635
KLHDC1 kelch domain containing 1 3.37635
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 3.37635
TSKS testis-specific serine kinase substrate 3.37635
DHRS2 dehydrogenase/reductase (SDR family) member 2 3.37635
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 3.37635
INPP1 inositol polyphosphate-1-phosphatase 3.36474
CA8 carbonic anhydrase VIII 3.35791
CORIN corin, serine peptidase 3.25857
IL17D interleukin 17D 3.25857
RAB39B RAB39B, member RAS oncogene family 3.25857
MYO3B myosin IIIB 3.25857
MLX MLX, MAX dimerization protein 3.19091
ATG4A autophagy related 4A, cysteine peptidase 3.15784
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 3.1417
TPM3 tropomyosin 3 3.10508
DNAI2 dynein, axonemal, intermediate chain 2 3.00575
PACS2 phosphofurin acidic cluster sorting protein 2 2.99582
PTCD1 pentatricopeptide repeat domain 1 2.7786
C8ORF88 chromosome 8 open reading frame 88 2.76125
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) 2.73766
ACOXL acyl-CoA oxidase-like 2.67836
HPS4 Hermansky-Pudlak syndrome 4 2.6692
ZNF510 zinc finger protein 510 2.66236
TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa 2.61573
ERLIN2 ER lipid raft associated 2 2.55246
TASOR2 transcription activation suppressor family member 2 2.50082
PCDH7 protocadherin 7 2.48886
WDR72 WD repeat domain 72 2.42902
FAM186A family with sequence similarity 186, member A 2.42555
CREG2 cellular repressor of E1A-stimulated genes 2 2.42555
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 2.41822
TRAF3IP3 TRAF3 interacting protein 3 2.40236
TOP1 topoisomerase (DNA) I 2.3908
TMEM114 transmembrane protein 114 2.38449
GNG2 guanine nucleotide binding protein (G protein), gamma 2 2.37191
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 2.36087
C1QBP complement component 1, q subcomponent binding protein 2.36004
MFAP3 microfibrillar-associated protein 3 2.35859
MPC2 mitochondrial pyruvate carrier 2 2.33037
TTF1 transcription termination factor, RNA polymerase I 2.33037
OCA2 oculocutaneous albinism II 2.33037
SNRPG small nuclear ribonucleoprotein polypeptide G 2.30432
FADS6 fatty acid desaturase 6 2.27452
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 2.25712
ACKR3 atypical chemokine receptor 3 2.25712
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2 2.25712
IRX3 iroquois homeobox 3 2.25712
CBY3 chibby homolog 3 (Drosophila) 2.25712
PKP3 plakophilin 3 2.25712
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 2.25712
OR2AG2 olfactory receptor, family 2, subfamily AG, member 2 2.25712
OR2A7 olfactory receptor, family 2, subfamily A, member 7 2.25712
PCDH19 protocadherin 19 2.25712
FPGT fucose-1-phosphate guanylyltransferase 2.25712
SERP1 stress-associated endoplasmic reticulum protein 1 2.21485
DEUP1 deuterosome assembly protein 1 2.21065
PNN pinin, desmosome associated protein 2.19332
MOSPD3 motile sperm domain containing 3 2.19091
ZNF620 zinc finger protein 620 2.189
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae) 2.18417
GARNL3 GTPase activating Rap/RanGAP domain-like 3 2.15709
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9 2.14309
MRPL19 mitochondrial ribosomal protein L19 2.14309
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa 2.14309
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 2.13626
METTL2B methyltransferase like 2B 2.12688
NOP10 NOP10 ribonucleoprotein 2.12161
BAK1 BCL2-antagonist/killer 1 2.08546
UBR2 ubiquitin protein ligase E3 component n-recognin 2 2.08546
AACS acetoacetyl-CoA synthetase 2.08546
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 2.08546
HNRNPM heterogeneous nuclear ribonucleoprotein M 2.08495
HAVCR2 hepatitis A virus cellular receptor 2 2.06553
TMEM245 transmembrane protein 245 2.06361

decreased expression

Symbol Name Standardized Value
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -3.37635
SHE Src homology 2 domain containing E -3.37635
LARP4 La ribonucleoprotein domain family, member 4 -3.37635
FBXO24 F-box protein 24 -3.37635
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 -3.37635
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 -3.37635
R3HDML R3H domain containing-like -3.37635
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 -3.37635
NTNG2 netrin G2 -3.37635
TGM2 transglutaminase 2 -3.37635
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 -3.37635
LAMP3 lysosomal-associated membrane protein 3 -3.37635
MT1M metallothionein 1M -3.37635
C8ORF76 chromosome 8 open reading frame 76 -3.37635
DPPA3 developmental pluripotency associated 3 -3.37635
TUBA4B tubulin, alpha 4b -3.37635
SPAG4 sperm associated antigen 4 -3.37635
C3 complement component 3 -3.37635
SCIMP SLP adaptor and CSK interacting membrane protein -3.37635
REC114 REC114 meiotic recombination protein -3.37635
FAM43B family with sequence similarity 43, member B -3.37635
SERTAD4 SERTA domain containing 4 -3.37635
PTGR3 prostaglandin reductase 3 -3.37635
CD6 CD6 molecule -3.37635
PTX3 pentraxin 3, long -3.37635
BMP8A bone morphogenetic protein 8a -3.37635
UNC45B unc-45 homolog B (C. elegans) -3.37635
PRAM1 PML-RARA regulated adaptor molecule 1 -3.37635
CCDC170 coiled-coil domain containing 170 -3.37635
NUTM1 NUT midline carcinoma, family member 1 -3.37635
AMH anti-Mullerian hormone -3.37635
SFRP4 secreted frizzled-related protein 4 -3.37635
CD52 CD52 molecule -3.37635
TFAP2E transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) -3.37635
STK11IP serine/threonine kinase 11 interacting protein -3.37635
CBX4 chromobox homolog 4 -3.37635
SSC5D scavenger receptor cysteine rich family, 5 domains -3.37635
ZMYND15 zinc finger, MYND-type containing 15 -3.37635
MAMLD1 mastermind-like domain containing 1 -3.37635
FAM78A family with sequence similarity 78, member A -3.23921
ZNF223 zinc finger protein 223 -3.23921
SCRN3 secernin 3 -3.16747
C4ORF51 chromosome 4 open reading frame 51 -3.0907
EPSTI1 epithelial stromal interaction 1 (breast) -3.01636
ATP5MF ATP synthase membrane subunit f -3.00624
PIGO phosphatidylinositol glycan anchor biosynthesis, class O -2.94017
GALK1 galactokinase 1 -2.93452
TTLL5 tubulin tyrosine ligase-like family member 5 -2.84175
PSEN2 presenilin 2 -2.83305
C1QTNF3 C1q and tumor necrosis factor related protein 3 -2.80349
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5 -2.68584
IFITM2 interferon induced transmembrane protein 2 -2.66236
CD83 CD83 molecule -2.59594
YME1L1 YME1-like 1 ATPase -2.58121
TRIM47 tripartite motif containing 47 -2.5322
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha -2.47341
GAS2 growth arrest-specific 2 -2.45986
N4BP2L2 NEDD4 binding protein 2-like 2 -2.45172
FKBPL FK506 binding protein like -2.41822
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -2.41822
C19ORF84 chromosome 19 open reading frame 84 -2.40745
CHIC1 cysteine-rich hydrophobic domain 1 -2.40745
LCOR ligand dependent nuclear receptor corepressor -2.395
TMOD2 tropomodulin 2 (neuronal) -2.39063
FNDC4 fibronectin type III domain containing 4 -2.3739
CYREN cell cycle regulator of NHEJ -2.36087
TBL2 transducin (beta)-like 2 -2.36087
SOGA1 suppressor of glucose, autophagy associated 1 -2.36004
PHLDA1 pleckstrin homology-like domain, family A, member 1 -2.36004
USP24 ubiquitin specific peptidase 24 -2.33349
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -2.32392
SNX1 sorting nexin 1 -2.32369
ZNF428 zinc finger protein 428 -2.31465
DRG2 developmentally regulated GTP binding protein 2 -2.31465
EFCAB6 EF-hand calcium binding domain 6 -2.30457
PNPT1 polyribonucleotide nucleotidyltransferase 1 -2.29665
PABIR1 PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 -2.29388
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -2.29075
CTTN cortactin -2.25712
GPR78 G protein-coupled receptor 78 -2.25339
PP2D1 protein phosphatase 2C-like domain containing 1 -2.25339
FOXL2 forkhead box L2 -2.25339
SULF2 sulfatase 2 -2.25001
GPR156 G protein-coupled receptor 156 -2.24727
TIGD6 tigger transposable element derived 6 -2.2436
AHNAK AHNAK nucleoprotein -2.2198
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) -2.1996
ZNF513 zinc finger protein 513 -2.18417
KLHL22 kelch-like family member 22 -2.15709
BUB1B-PAK6 BUB1B-PAK6 readthrough -2.15006
EGFLAM EGF-like, fibronectin type III and laminin G domains -2.09006
ZBTB40 zinc finger and BTB domain containing 40 -2.07957
ETAA1 Ewing tumor-associated antigen 1 -2.07404
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) -2.06559
ABHD6 abhydrolase domain containing 6 -2.06399
LZIC leucine zipper and CTNNBIP1 domain containing -2.06361
POLR3H polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) -2.04597
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase -2.03344
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 -2.02154
DOC2B double C2-like domains, beta -2.02154