PRNP Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description prion protein|The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] (NCBI Entrez Gene Database, 5621)
External Link http://www.ncbi.nlm.nih.gov/gene/5621
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180 interacting proteins for PRNP from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABT1 activator of basal transcription 1
ADAP2 ArfGAP with dual PH domains 2
ADGRL4 adhesion G protein-coupled receptor L4
AGO1 argonaute RISC catalytic component 1
AGO2 argonaute RISC catalytic component 2
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3
ALDOC aldolase C, fructose-bisphosphate
ANXA2 annexin A2
APP amyloid beta (A4) precursor protein
ARHGAP15 Rho GTPase activating protein 15
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
BAG6 BCL2-associated athanogene 6
BASP1 brain abundant, membrane attached signal protein 1
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BSG basigin (Ok blood group)
C7ORF50 chromosome 7 open reading frame 50
CA4 carbonic anhydrase IV
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC149 coiled-coil domain containing 149
CD40 CD40 molecule, TNF receptor superfamily member 5
CD47 CD47 molecule
CD59 CD59 molecule, complement regulatory protein
CD63 CD63 molecule
CIRBP cold inducible RNA binding protein
CIRH1A cirrhosis, autosomal recessive 1A (cirhin)
CLDND1 claudin domain containing 1
CLIC4 chloride intracellular channel 4
CLTC clathrin, heavy chain (Hc)
CLU clusterin
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CNTN1 contactin 1
COX5A cytochrome c oxidase subunit Va
COX5B cytochrome c oxidase subunit Vb
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
COX6C cytochrome c oxidase subunit VIc
CSN3 casein kappa
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSNK2B casein kinase 2, beta polypeptide
CWC15 CWC15 spliceosome-associated protein
CYC1 cytochrome c-1
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
DICER1 dicer 1, ribonuclease type III
DIRAS2 DIRAS family, GTP-binding RAS-like 2
DPYSL2 dihydropyrimidinase-like 2
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EMP1 epithelial membrane protein 1
EMP3 epithelial membrane protein 3
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FAM27E3 family with sequence similarity 27, member E3
FAM64A family with sequence similarity 64, member A
FAP fibroblast activation protein, alpha
FBN2 fibrillin 2
FGF13 fibroblast growth factor 13
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
GFAP glial fibrillary acidic protein
GLMP glycosylated lysosomal membrane protein
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GPM6A glycoprotein M6A
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HLA-B major histocompatibility complex, class I, B
HOXA1 homeobox A1
HSPA4 heat shock 70kDa protein 4
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HTT huntingtin
ICAM2 intercellular adhesion molecule 2
IER3 immediate early response 3
IL13RA2 interleukin 13 receptor, alpha 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KIAA1191 KIAA1191
KRT1 keratin 1, type II
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LGALS1 lectin, galactoside-binding, soluble, 1
LNPEP leucyl/cystinyl aminopeptidase
MAPT microtubule-associated protein tau
MARK4 MAP/microtubule affinity-regulating kinase 4
MCAM melanoma cell adhesion molecule
MPG N-methylpurine-DNA glycosylase
MPZL1 myelin protein zero-like 1
MPZL2 myelin protein zero-like 2
MTG1 mitochondrial ribosome-associated GTPase 1
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
NEGR1 neuronal growth regulator 1
NEO1 neogenin 1
NHP2 NHP2 ribonucleoprotein
NOB1 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)
NPC1 Niemann-Pick disease, type C1
NPTN neuroplastin
NT5E 5'-nucleotidase, ecto (CD73)
NTM neurotrimin
OPCML opioid binding protein/cell adhesion molecule-like
P4HB prolyl 4-hydroxylase, beta polypeptide
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDE4DIP phosphodiesterase 4D interacting protein
PDIA6 protein disulfide isomerase family A, member 6
PLG plasminogen
PLK3 polo-like kinase 3
PLP1 proteolipid protein 1
PPAP2C phosphatidic acid phosphatase type 2C
PPARG peroxisome proliferator-activated receptor gamma
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PTPRJ protein tyrosine phosphatase, receptor type, J
PTRH1 peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAP1A RAP1A, member of RAS oncogene family
RBM22 RNA binding motif protein 22
RNPC3 RNA-binding region (RNP1, RRM) containing 3
RPL41 ribosomal protein L41
SCARB2 scavenger receptor class B, member 2
SCNM1 sodium channel modifier 1
SEPT7 septin 7
SIRPA signal-regulatory protein alpha
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC43A3 solute carrier family 43, member 3
SLC46A1 solute carrier family 46 (folate transporter), member 1
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SNAP25 synaptosomal-associated protein, 25kDa
SPPL2A signal peptide peptidase like 2A
SRRM2 serine/arginine repetitive matrix 2
STIP1 stress-induced phosphoprotein 1
STX1A syntaxin 1A (brain)
STX1B syntaxin 1B
STXBP1 syntaxin binding protein 1
SURF2 surfeit 2
SYP synaptophysin
SYPL1 synaptophysin-like 1
SYT2 synaptotagmin II
TBPL1 TBP-like 1
THY1 Thy-1 cell surface antigen
TMEM181 transmembrane protein 181
TMEM206 transmembrane protein 206
TMEM237 transmembrane protein 237
TMEM87A transmembrane protein 87A
TNRC6A trinucleotide repeat containing 6A
TPP1 tripeptidyl peptidase I
TSC22D4 TSC22 domain family, member 4
TSLP thymic stromal lymphopoietin
TSPAN3 tetraspanin 3
UQCRC1 ubiquinol-cytochrome c reductase core protein I
UQCRC2 ubiquinol-cytochrome c reductase core protein II
UQCRH ubiquinol-cytochrome c reductase hinge protein
VDAC1 voltage-dependent anion channel 1
VDAC2 voltage-dependent anion channel 2
VDAC3 voltage-dependent anion channel 3
WDR5 WD repeat domain 5
WIBG within bgcn homolog (Drosophila)
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
ZFYVE28 zinc finger, FYVE domain containing 28
ZKSCAN8 zinc finger with KRAB and SCAN domains 8
ZNF408 zinc finger protein 408
ZNF740 zinc finger protein 740