PROS1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description protein S (alpha)|This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. [provided by RefSeq, Feb 2009] (NCBI Entrez Gene Database, 5627)
External Link http://www.ncbi.nlm.nih.gov/gene/5627
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69 interacting proteins for PROS1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
A1BG alpha-1-B glycoprotein
A2M alpha-2-macroglobulin
AHSG alpha-2-HS-glycoprotein
ALB albumin
AMBP alpha-1-microglobulin/bikunin precursor
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOA4 apolipoprotein A-IV
APOC1 apolipoprotein C-I
APOC2 apolipoprotein C-II
APOC3 apolipoprotein C-III
APOE apolipoprotein E
APOM apolipoprotein M
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C3 complement component 3
C4A complement component 4A (Rodgers blood group)
C4BPA complement component 4 binding protein, alpha
C4BPB complement component 4 binding protein, beta
C6 complement component 6
C9 complement component 9
CD5L CD5 molecule-like
CFB complement factor B
CFH complement factor H
CLU clusterin
COL6A6 collagen, type VI, alpha 6
CP ceruloplasmin (ferroxidase)
EPYC epiphycan
F10 coagulation factor X
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
F8 coagulation factor VIII, procoagulant component
F9 coagulation factor IX
FBXO6 F-box protein 6
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FN1 fibronectin 1
FURIN furin (paired basic amino acid cleaving enzyme)
GC group-specific component (vitamin D binding protein)
GGCX gamma-glutamyl carboxylase
HRG histidine-rich glycoprotein
IGHG2 immunoglobulin heavy constant gamma 2 (G2m marker)
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4
KIAA0753 KIAA0753
KIRREL kin of IRRE like (Drosophila)
KNG1 kininogen 1
LBP lipopolysaccharide binding protein
LUM lumican
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
OPTN optineurin
PLG plasminogen
PON1 paraoxonase 1
PROC protein C (inactivator of coagulation factors Va and VIIIa)
RPSA ribosomal protein SA
SAA2 serum amyloid A2
SAA4 serum amyloid A4, constitutive
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SHBG sex hormone-binding globulin
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
TBK1 TANK-binding kinase 1
TRIM33 tripartite motif containing 33
TTR transthyretin
TYRO3 TYRO3 protein tyrosine kinase
VTN vitronectin