PRRX2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description paired related homeobox 2|The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 51450)
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Genes

309 genes differentially expressed following the PRRX2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TMEM191B transmembrane protein 191B 3.246
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 3.246
BHLHE40 basic helix-loop-helix family, member e40 3.246
PRLR prolactin receptor 3.246
TMEM217 transmembrane protein 217 3.246
RTN4IP1 reticulon 4 interacting protein 1 3.246
SHE Src homology 2 domain containing E 3.246
ADAT3 adenosine deaminase, tRNA-specific 3 3.246
LRRIQ4 leucine-rich repeats and IQ motif containing 4 3.246
PTGFR prostaglandin F receptor (FP) 3.246
RFPL3 ret finger protein-like 3 3.246
ADAD2 adenosine deaminase domain containing 2 3.246
GJB4 gap junction protein, beta 4, 30.3kDa 3.246
RNF43 ring finger protein 43 3.246
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 3.246
BMP8A bone morphogenetic protein 8a 3.246
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 3.246
NEU4 sialidase 4 3.246
SSTR3 somatostatin receptor 3 3.246
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 3.246
MISP mitotic spindle positioning 3.246
LRRC63 leucine rich repeat containing 63 3.246
CRYGA crystallin, gamma A 3.246
WAS Wiskott-Aldrich syndrome 3.246
MAST1 microtubule associated serine/threonine kinase 1 3.246
KRTAP12-1 keratin associated protein 12-1 3.246
PRSS21 protease, serine, 21 (testisin) 3.246
OXER1 oxoeicosanoid (OXE) receptor 1 3.246
RP1 retinitis pigmentosa 1 (autosomal dominant) 3.246
GPRC5D G protein-coupled receptor, class C, group 5, member D 3.246
TRAF3IP3 TRAF3 interacting protein 3 3.246
RNASE6 ribonuclease, RNase A family, k6 3.246
RNASE9 ribonuclease, RNase A family, 9 (non-active) 3.246
KRTAP5-2 keratin associated protein 5-2 3.246
AVP arginine vasopressin 3.246
SPHK1 sphingosine kinase 1 3.246
ACY3 aminoacylase 3 3.246
PRDM1 PR domain containing 1, with ZNF domain 3.246
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 3.246
KIAA1755 KIAA1755 3.246
SLC10A5 solute carrier family 10, member 5 3.246
STAP1 signal transducing adaptor family member 1 3.246
SPNS3 spinster homolog 3 (Drosophila) 3.246
TBC1D3I TBC1 domain family member 3I 3.246
FMO2 flavin containing monooxygenase 2 (non-functional) 3.246
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 3.246
NPIPB8 nuclear pore complex interacting protein family, member B8 3.246
GDF7 growth differentiation factor 7 3.246
GPR83 G protein-coupled receptor 83 3.246
VCX3B variable charge, X-linked 3B 3.246
S100G S100 calcium binding protein G 3.246
CCR4 chemokine (C-C motif) receptor 4 3.246
AVPR1B arginine vasopressin receptor 1B 3.246
TMOD4 tropomodulin 4 (muscle) 3.246
SEPTIN14 septin 14 3.246
WASL-DT WASL divergent transcript 3.246
PRRT1B proline rich transmembrane protein 1B 3.246
ZNF593OS ZNF593 opposite strand 3.246
SPAAR small regulatory polypeptide of amino acid response 3.246
CFAP276 cilia and flagella associated protein 276 3.246
MEIOSIN meiosis initiator 3.246
ERFE erythroferrone 3.246
CFAP141 cilia and flagella associated protein 141 3.246
GJD3 gap junction protein, delta 3, 31.9kDa 3.246
ARMS2 age-related maculopathy susceptibility 2 3.246
ZNF257 zinc finger protein 257 3.246
MYBPHL myosin binding protein H-like 3.246
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 3.246
RXFP1 relaxin/insulin-like family peptide receptor 1 3.246
ACTG2 actin, gamma 2, smooth muscle, enteric 3.246
NXPH4 neurexophilin 4 3.246
PGAM4 phosphoglycerate mutase family member 4 3.246
MUC1 mucin 1, cell surface associated 3.246
ADIPOQ adiponectin, C1Q and collagen domain containing 3.246
SPATA31F3 SPATA31 subfamily F member 3 3.246
LAPTM5 lysosomal protein transmembrane 5 3.246
GJA9 gap junction protein, alpha 9, 59kDa 3.246
TLR8 toll-like receptor 8 3.246
TLR1 toll-like receptor 1 3.246
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 3.246
GGT5 gamma-glutamyltransferase 5 3.246
DTHD1 death domain containing 1 3.246
LOC390937 Ets2 repressor factor-like 3.246
FAM153A family with sequence similarity 153, member A 3.246
SYCP2 synaptonemal complex protein 2 3.246
PCDHB6 protocadherin beta 6 3.246
SYNGR4 synaptogyrin 4 3.246
BCL3 B-cell CLL/lymphoma 3 3.246
SPATA3 spermatogenesis associated 3 3.246
C11ORF16 chromosome 11 open reading frame 16 3.246
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 3.246
TBC1D10C TBC1 domain family, member 10C 3.246
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 3.246
FAM222A family with sequence similarity 222, member A 3.246
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 3.246
CXCR4 chemokine (C-X-C motif) receptor 4 3.246
VNN2 vanin 2 3.246
APOC2 apolipoprotein C-II 3.246
BTNL3 butyrophilin-like 3 3.246
C6ORF163 chromosome 6 open reading frame 163 3.246
EFCAB3 EF-hand calcium binding domain 3 3.246
GP9 glycoprotein IX (platelet) 3.246
LCNL1 lipocalin-like 1 3.246
EDN3 endothelin 3 3.246
CLEC4G C-type lectin domain family 4, member G 3.246
MAMLD1 mastermind-like domain containing 1 3.246
RANBP3L RAN binding protein 3-like 3.246
ACSBG2 acyl-CoA synthetase bubblegum family member 2 3.246
CRYBA1 crystallin, beta A1 3.246
CSF1R colony stimulating factor 1 receptor 3.246
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 3.246
ITGB7 integrin, beta 7 3.246
BEAN1 brain expressed, associated with NEDD4, 1 3.246
CHIT1 chitinase 1 (chitotriosidase) 3.246
LY6G6D lymphocyte antigen 6 complex, locus G6D 3.246
KLK4 kallikrein-related peptidase 4 3.246
EPGN epithelial mitogen 3.246
NAT8 N-acetyltransferase 8 (GCN5-related, putative) 3.246
TEKT5 tektin 5 3.246
ABHD12B abhydrolase domain containing 12B 3.246
IP6K3 inositol hexakisphosphate kinase 3 3.246
AGXT2 alanine--glyoxylate aminotransferase 2 3.246
NUPR1 nuclear protein, transcriptional regulator, 1 3.246
PCDHGA2 protocadherin gamma subfamily A, 2 3.246
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 3.246
ESAM endothelial cell adhesion molecule 3.246
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 3.246
CARNS1 carnosine synthase 1 3.246
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 3.246
TRPM5 transient receptor potential cation channel, subfamily M, member 5 3.246
TEX35 testis expressed 35 3.246
MT1A metallothionein 1A 3.246
TMPRSS13 transmembrane protease, serine 13 3.246
CHRM1 cholinergic receptor, muscarinic 1 3.246
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 3.246
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 3.246
TMEM156 transmembrane protein 156 3.246
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 3.246
SEZ6L seizure related 6 homolog (mouse)-like 3.246
FCAR Fc fragment of IgA receptor 3.246
PSORS1C1 psoriasis susceptibility 1 candidate 1 3.246
ARHGAP40 Rho GTPase activating protein 40 3.246
SPRN shadow of prion protein homolog (zebrafish) 3.246
CGA glycoprotein hormones, alpha polypeptide 3.246
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 3.246
RUFY4 RUN and FYVE domain containing 4 3.246
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 3.246
GNG8 guanine nucleotide binding protein (G protein), gamma 8 3.246
TTC24 tetratricopeptide repeat domain 24 3.246
PRAM1 PML-RARA regulated adaptor molecule 1 3.246
SUN3 Sad1 and UNC84 domain containing 3 3.246
SLC17A2 solute carrier family 17, member 2 3.246
DRC1 dynein regulatory complex subunit 1 3.246
SP100 SP100 nuclear antigen 3.246
C10ORF88 chromosome 10 open reading frame 88 3.19539
LPP LIM domain containing preferred translocation partner in lipoma 3.15583
LDB3 LIM domain binding 3 3.14635
FAM131B family with sequence similarity 131, member B 3.02464
C1D C1D nuclear receptor corepressor 3.02368
NABP2 nucleic acid binding protein 2 2.92659
RASA1 RAS p21 protein activator (GTPase activating protein) 1 2.90561
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 2.90561
SHISA2 shisa family member 2 2.90061
RNF4 ring finger protein 4 2.84625
RSPH14 radial spoke head 14 homolog (Chlamydomonas) 2.77951
GCNT7 glucosaminyl (N-acetyl) transferase family member 7 2.72129
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 2.66347
WNT3A wingless-type MMTV integration site family, member 3A 2.66347
EMILIN1 elastin microfibril interfacer 1 2.58826
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 2.58826
GALE UDP-galactose-4-epimerase 2.57135
FAM133B family with sequence similarity 133, member B 2.55476
IFNLR1 interferon, lambda receptor 1 2.47598
SPDYE2 speedy/RINGO cell cycle regulator family member E2 2.4058
CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) 2.38827
INHBA inhibin, beta A 2.35513
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 2.35513
FLRT3 fibronectin leucine rich transmembrane protein 3 2.35513
CD177 CD177 molecule 2.35513
PON3 paraoxonase 3 2.35513
CBX4 chromobox homolog 4 2.35513
FAM193B family with sequence similarity 193, member B 2.35513
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 2.34939
FBXO46 F-box protein 46 2.34475
GALM galactose mutarotase (aldose 1-epimerase) 2.34323
MYO16 myosin XVI 2.3321
TMEM81 transmembrane protein 81 2.32531
PRRT4 proline-rich transmembrane protein 4 2.28315
MEP1B meprin A, beta 2.27011
GEMIN8 gem (nuclear organelle) associated protein 8 2.23765
JCAD junctional cadherin 5 associated 2.20992
HABP4 hyaluronan binding protein 4 2.20992
COPG2 coatomer protein complex, subunit gamma 2 2.20445
PTPRG protein tyrosine phosphatase, receptor type, G 2.20424
GDAP1L1 ganglioside induced differentiation associated protein 1-like 1 2.20224
PRPS1 phosphoribosyl pyrophosphate synthetase 1 2.19766
ZNF724 zinc finger protein 724 2.17337
SEPTIN5 septin 5 2.17337
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 2.17337
ACYP1 acylphosphatase 1, erythrocyte (common) type 2.17337
MOB3C MOB kinase activator 3C 2.17337
LIPA lipase A, lysosomal acid, cholesterol esterase 2.14109
ARMCX6 armadillo repeat containing, X-linked 6 2.09865
KIDINS220 kinase D-interacting substrate, 220kDa 2.09768
SASH1 SAM and SH3 domain containing 1 2.08569
IQCE IQ motif containing E 2.08424
RFXAP regulatory factor X-associated protein 2.06021
CLCC1 chloride channel CLIC-like 1 2.05742
HPS1 Hermansky-Pudlak syndrome 1 2.0391
SFXN5 sideroflexin 5 2.02278
ADGRF3 adhesion G protein-coupled receptor F3 2.01594
NCLN nicalin 2.00346

decreased expression

Symbol Name Standardized Value
MAGED1 melanoma antigen family D1 -3.246
PLCL1 phospholipase C-like 1 -3.246
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 -3.246
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa -3.246
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 -3.246
CCDC91 coiled-coil domain containing 91 -3.246
PP2D1 protein phosphatase 2C-like domain containing 1 -3.246
GPR34 G protein-coupled receptor 34 -3.246
ADPRHL1 ADP-ribosylhydrolase like 1 -3.246
P2RY12 purinergic receptor P2Y, G-protein coupled, 12 -3.246
GFY golgi-associated, olfactory signaling regulator -3.246
CD1D CD1d molecule -3.246
CLSTN1 calsyntenin 1 -3.00566
POLR1E polymerase (RNA) I polypeptide E, 53kDa -2.99571
NPSR1 neuropeptide S receptor 1 -2.98754
CIMAP1D CIMAP1 family member D -2.98754
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -2.98754
GAD1 glutamate decarboxylase 1 (brain, 67kDa) -2.98754
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 -2.98754
TMEM86A transmembrane protein 86A -2.98754
MMP3 matrix metallopeptidase 3 -2.98754
PAX6 paired box 6 -2.98754
FOXA2 forkhead box A2 -2.98754
H4C13 H4 clustered histone 13 -2.98754
DNAAF8 dynein axonemal assembly factor 8 -2.98754
PLAAT4 phospholipase A and acyltransferase 4 -2.98754
LBHD1 LBH domain containing 1 -2.98754
C1ORF87 chromosome 1 open reading frame 87 -2.98754
SCRG1 stimulator of chondrogenesis 1 -2.98754
GJA5 gap junction protein, alpha 5, 40kDa -2.98754
IL4I1 interleukin 4 induced 1 -2.98754
RASL10A RAS-like, family 10, member A -2.98754
TMIGD2 transmembrane and immunoglobulin domain containing 2 -2.98754
TAPBPL TAP binding protein-like -2.98754
TF transferrin -2.98754
ZNF831 zinc finger protein 831 -2.98754
SCNN1B sodium channel, non voltage gated 1 beta subunit -2.98754
CTSS cathepsin S -2.98754
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 -2.98754
NYX nyctalopin -2.98754
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B -2.98754
PABPC4L poly(A) binding protein, cytoplasmic 4-like -2.96642
NOS2 nitric oxide synthase 2, inducible -2.91087
GPR63 G protein-coupled receptor 63 -2.87432
KDM2A lysine (K)-specific demethylase 2A -2.87432
TCEAL1 transcription elongation factor A (SII)-like 1 -2.87342
ANKRD7 ankyrin repeat domain 7 -2.87342
MSS51 MSS51 mitochondrial translational activator -2.87342
ATR ATR serine/threonine kinase -2.87033
RUNDC3A RUN domain containing 3A -2.83442
SETD7 SET domain containing (lysine methyltransferase) 7 -2.83253
APOM apolipoprotein M -2.81661
ZNF672 zinc finger protein 672 -2.77951
ZNF526 zinc finger protein 526 -2.68551
CLDN19 claudin 19 -2.68042
RUFY2 RUN and FYVE domain containing 2 -2.67166
KBTBD8 kelch repeat and BTB (POZ) domain containing 8 -2.67166
GLRX glutaredoxin (thioltransferase) -2.62016
STK25 serine/threonine kinase 25 -2.57739
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -2.53434
TNXB tenascin XB -2.5258
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) -2.5146
ZNF621 zinc finger protein 621 -2.48792
KDSR 3-ketodihydrosphingosine reductase -2.43243
BANF1 barrier to autointegration factor 1 -2.38827
ATXN2L ataxin 2-like -2.37957
COL11A1 collagen, type XI, alpha 1 -2.35513
TPRKB TP53RK binding protein -2.35513
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa -2.35513
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 -2.34939
COQ5 coenzyme Q5 homolog, methyltransferase (S. cerevisiae) -2.34939
OXCT1 3-oxoacid CoA transferase 1 -2.33435
MIEF1 mitochondrial elongation factor 1 -2.3225
SPRYD3 SPRY domain containing 3 -2.31285
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 -2.31285
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -2.2722
USP6 ubiquitin specific peptidase 6 -2.26139
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -2.23886
PYGO1 pygopus family PHD finger 1 -2.23475
LPAR6 lysophosphatidic acid receptor 6 -2.23223
EFHB EF-hand domain family, member B -2.23223
COL8A2 collagen, type VIII, alpha 2 -2.22011
COPS7B COP9 signalosome subunit 7B -2.21873
SPATC1 spermatogenesis and centriole associated 1 -2.19766
ERMAP erythroblast membrane-associated protein (Scianna blood group) -2.19766
SLC38A6 solute carrier family 38, member 6 -2.19766
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic -2.19766
ASTE1 asteroid homolog 1 (Drosophila) -2.179
BCORL1 BCL6 corepressor-like 1 -2.17732
ZNF8 zinc finger protein 8 -2.13612
DCTN1 dynactin 1 -2.05799
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.02658
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -2.02278
SRP54 signal recognition particle 54kDa -2.00769
TBPL1 TBP-like 1 -2.00725
GCK glucokinase (hexokinase 4) -2.00687
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -2.00346