PSD Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description pleckstrin and Sec7 domain containing|This gene encodes a Plekstrin homology and SEC7 domains-containing protein that functions as a guanine nucleotide exchange factor. The encoded protein regulates signal transduction by activating ADP-ribosylation factor 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] (NCBI Entrez Gene Database, 5662)
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Genes

352 genes differentially expressed following the PSD gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
DHRS9 dehydrogenase/reductase (SDR family) member 9 3.04387
C6ORF118 chromosome 6 open reading frame 118 3.00797
LGALS4 lectin, galactoside-binding, soluble, 4 3.00797
ERLEC1 endoplasmic reticulum lectin 1 3.00797
RNF133 ring finger protein 133 3.00797
LRRC71 leucine rich repeat containing 71 3.00797
ZAR1L zygote arrest 1-like 3.00797
SPACA3 sperm acrosome associated 3 3.00797
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 3.00797
BOLA2 bolA family member 2 3.00797
CAPS calcyphosine 3.00797
VCX3B variable charge, X-linked 3B 3.00797
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 3.00797
C3ORF22 chromosome 3 open reading frame 22 3.00797
MS4A14 membrane-spanning 4-domains, subfamily A, member 14 3.00797
OCSTAMP osteoclast stimulatory transmembrane protein 3.00797
EXOC3L1 exocyst complex component 3-like 1 3.00797
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 3.00797
TCP11 t-complex 11, testis-specific 3.00797
IL2RB interleukin 2 receptor, beta 3.00797
ACOT12 acyl-CoA thioesterase 12 3.00797
KRTAP5-2 keratin associated protein 5-2 3.00797
TPRX1 tetra-peptide repeat homeobox 1 3.00797
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 3.00797
LAG3 lymphocyte-activation gene 3 3.00797
PLA2G1B phospholipase A2, group IB (pancreas) 3.00797
SHISA3 shisa family member 3 3.00797
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 3.00797
KCNK15 potassium channel, two pore domain subfamily K, member 15 3.00797
ANXA1 annexin A1 3.00797
CPLX1 complexin 1 3.00797
PADI4 peptidyl arginine deiminase, type IV 3.00797
RP1 retinitis pigmentosa 1 (autosomal dominant) 3.00797
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 3.00797
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 3.00797
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 3.00797
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 3.00797
PLCZ1 phospholipase C, zeta 1 3.00797
WFDC13 WAP four-disulfide core domain 13 3.00797
R3HDM2 R3H domain containing 2 3.00797
TSSK1B testis-specific serine kinase 1B 3.00797
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 3.00797
PASD1 PAS domain containing 1 3.00797
PADI1 peptidyl arginine deiminase, type I 3.00797
MYOM2 myomesin 2 3.00797
CLEC3A C-type lectin domain family 3, member A 3.00797
GJA9 gap junction protein, alpha 9, 59kDa 3.00797
OLAH oleoyl-ACP hydrolase 3.00797
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 3.00797
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 3.00797
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 3.00797
ASB15 ankyrin repeat and SOCS box containing 15 3.00797
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 3.00797
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 3.00797
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 3.00797
GPR6 G protein-coupled receptor 6 3.00797
RAET1E retinoic acid early transcript 1E 3.00797
NXPE4 neurexophilin and PC-esterase domain family, member 4 3.00797
ITK IL2-inducible T-cell kinase 3.00797
PCDHB11 protocadherin beta 11 3.00797
PTPRC protein tyrosine phosphatase, receptor type, C 3.00797
CCR6 chemokine (C-C motif) receptor 6 3.00797
NKX2-6 NK2 homeobox 6 3.00797
IL31RA interleukin 31 receptor A 3.00797
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 3.00797
TBX21 T-box 21 3.00797
SIGLECL1 SIGLEC family like 1 3.00797
SCRT2 scratch family zinc finger 2 3.00797
SLAMF7 SLAM family member 7 3.00797
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 3.00797
LRRC55 leucine rich repeat containing 55 3.00797
PAX7 paired box 7 3.00797
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 3.00797
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 3.00797
ARHGAP36 Rho GTPase activating protein 36 3.00797
PRR18 proline rich 18 3.00797
ASPN asporin 3.00797
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 3.00797
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 3.00797
ZNF575 zinc finger protein 575 3.00797
TPTE transmembrane phosphatase with tensin homology 3.00797
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 3.00797
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 3.00797
TMEM176A transmembrane protein 176A 3.00797
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 3.00797
PDIA2 protein disulfide isomerase family A, member 2 3.00797
WNT3A wingless-type MMTV integration site family, member 3A 3.00797
GPR151 G protein-coupled receptor 151 3.00797
C19ORF67 chromosome 19 open reading frame 67 3.00797
GREM1 gremlin 1, DAN family BMP antagonist 3.00797
TRIM75 tripartite motif containing 75 3.00797
OR52K1 olfactory receptor, family 52, subfamily K, member 1 3.00797
VWA7 von Willebrand factor A domain containing 7 3.00797
IL1B interleukin 1, beta 3.00797
SPMIP3 sperm microtubule inner protein 3 3.00797
FBXO40 F-box protein 40 3.00797
PCDHA11 protocadherin alpha 11 3.00797
PRPH peripherin 3.00797
HLA-DOB major histocompatibility complex, class II, DO beta 3.00797
ANKRD55 ankyrin repeat domain 55 3.00797
OR2L3 olfactory receptor, family 2, subfamily L, member 3 3.00797
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 3.00797
EVPLL envoplakin-like 3.00797
SPO11 SPO11 meiotic protein covalently bound to DSB 3.00797
CALHM2 calcium homeostasis modulator 2 3.00797
HKDC1 hexokinase domain containing 1 3.00797
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 3.00797
CPA3 carboxypeptidase A3 (mast cell) 3.00797
CPA2 carboxypeptidase A2 (pancreatic) 3.00797
CLEC4C C-type lectin domain family 4, member C 3.00797
ZNF593OS ZNF593 opposite strand 3.00797
PRRT1B proline rich transmembrane protein 1B 3.00797
ANKRD53 ankyrin repeat domain 53 3.00797
PIP prolactin-induced protein 3.00797
SCNN1B sodium channel, non voltage gated 1 beta subunit 3.00797
RASA4 RAS p21 protein activator 4 3.00797
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 3.00797
PLA2G2E phospholipase A2, group IIE 3.00797
HPGDS hematopoietic prostaglandin D synthase 3.00797
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 3.00797
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 3.00797
SIDT1 SID1 transmembrane family, member 1 3.00797
SPATA31H1 SPATA31 subfamily H member 1 3.00797
CRTAM cytotoxic and regulatory T cell molecule 3.00797
FAM240C family with sequence similarity 240 member C 3.00797
CAPSL calcyphosine-like 3.00797
MYADML2 myeloid-associated differentiation marker-like 2 3.00797
SIGLEC15 sialic acid binding Ig-like lectin 15 3.00797
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 3.00797
TMEM31 transmembrane protein 31 3.00797
PGR progesterone receptor 3.00797
UBXN10 UBX domain protein 10 3.00797
SLC38A8 solute carrier family 38, member 8 3.00797
CSDC2 cold shock domain containing C2, RNA binding 3.00797
QRFP pyroglutamylated RFamide peptide 3.00797
LRRC25 leucine rich repeat containing 25 3.00797
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 3.00797
ISX intestine-specific homeobox 3.00797
LST1 leukocyte specific transcript 1 3.00797
SLITRK2 SLIT and NTRK-like family, member 2 3.00797
NUTM2A NUT family member 2A 3.00797
GPX5 glutathione peroxidase 5 3.00797
C3AR1 complement component 3a receptor 1 3.00797
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 3.00797
TMEM150B transmembrane protein 150B 3.00797
SMIM22 small integral membrane protein 22 3.00797
CHRM1 cholinergic receptor, muscarinic 1 3.00797
DEFB134 defensin, beta 134 3.00797
SDSL serine dehydratase-like 3.00797
KRT86 keratin 86, type II 3.00797
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 3.00797
AGBL4 ATP/GTP binding protein-like 4 3.00797
CLCNKB chloride channel, voltage-sensitive Kb 3.00797
CAPN9 calpain 9 3.00797
LAMP3 lysosomal-associated membrane protein 3 3.00797
RNF222 ring finger protein 222 3.00797
PHOSPHO1 phosphatase, orphan 1 3.00797
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 3.00797
HP haptoglobin 3.00797
RSAD2 radical S-adenosyl methionine domain containing 2 3.00797
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 3.00797
CABCOCO1 ciliary associated calcium binding coiled-coil 1 3.00797
NIM1K NIM1 serine/threonine protein kinase 3.00797
ASB11 ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase 3.00797
C18ORF63 chromosome 18 open reading frame 63 3.00797
ARR3 arrestin 3, retinal (X-arrestin) 3.00797
DPRX divergent-paired related homeobox 3.00797
TMEM270 transmembrane protein 270 3.00797
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 3.00797
CCN5 cellular communication network factor 5 3.00797
ALAS2 5'-aminolevulinate synthase 2 3.00797
ZNF366 zinc finger protein 366 3.00797
LY6L lymphocyte antigen 6 family member L 3.00797
A3GALT2 alpha 1,3-galactosyltransferase 2 3.00797
LRRC46 leucine rich repeat containing 46 3.00797
UBA6 ubiquitin-like modifier activating enzyme 6 2.97026
PROM1 prominin 1 2.89715
RIOX2 ribosomal oxygenase 2 2.87012
PPP6R3 protein phosphatase 6, regulatory subunit 3 2.87012
RPRD1A regulation of nuclear pre-mRNA domain containing 1A 2.84395
NUDT14 nudix (nucleoside diphosphate linked moiety X)-type motif 14 2.75773
HAUS2 HAUS augmin-like complex, subunit 2 2.68646
NOB1 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) 2.67435
DCUN1D5 DCN1, defective in cullin neddylation 1, domain containing 5 2.61797
MFAP3L microfibrillar-associated protein 3-like 2.56903
ZNF609 zinc finger protein 609 2.55671
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 2.55544
SLC71A1 solute carrier family 71 member 1 2.54081
C12ORF75 chromosome 12 open reading frame 75 2.52698
WBP2 WW domain binding protein 2 2.50855
MAP2K3 mitogen-activated protein kinase kinase 3 2.49855
TMEM221 transmembrane protein 221 2.49439
STK17B serine/threonine kinase 17b 2.43264
KIF21A kinesin family member 21A 2.43264
ADCK1 aarF domain containing kinase 1 2.41328
FRAS1 Fraser extracellular matrix complex subunit 1 2.41121
TTC36 tetratricopeptide repeat domain 36 2.41064
LSM10 LSM10, U7 small nuclear RNA associated 2.40893
RYR3 ryanodine receptor 3 2.40622
XRRA1 X-ray radiation resistance associated 1 2.38301
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2.34567
CD47 CD47 molecule 2.34386
KATNBL1 katanin p80 subunit B-like 1 2.2782
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2 2.26287
RRAGB Ras-related GTP binding B 2.25365
SNAI3 snail family zinc finger 3 2.22494
SNN stannin 2.22494
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 2.22452
ALPK3 alpha-kinase 3 2.21452
FEN1 flap structure-specific endonuclease 1 2.21452
SPICE1 spindle and centriole associated protein 1 2.21452
SACK1G scaffolding CK1 anchoring protein G 2.21452
MCPH1 microcephalin 1 2.21452
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 2.20416
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 2.19793
MYO1B myosin IB 2.1819
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 2.17375
RMC1 regulator of MON1-CCZ1 2.14956
NABP2 nucleic acid binding protein 2 2.13482
CADPS2 Ca++-dependent secretion activator 2 2.12816
SARS2 seryl-tRNA synthetase 2, mitochondrial 2.127
BRD8 bromodomain containing 8 2.12309
ENTR1 endosome associated trafficking regulator 1 2.12178
HACD3 3-hydroxyacyl-CoA dehydratase 3 2.11968
SPOPL speckle-type POZ protein-like 2.11968
TYW1B tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae) 2.11704
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 2.09211
TXNL4B thioredoxin-like 4B 2.09033
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 2.08266
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial 2.06641
TMEM237 transmembrane protein 237 2.06549
HSH2D hematopoietic SH2 domain containing 2.06268
IDO2 indoleamine 2,3-dioxygenase 2 2.06268
GAGE10 G antigen 10 2.06268
DEPP1 DEPP autophagy regulator 1 2.06268
CCER2 coiled-coil glutamate-rich protein 2 2.06268
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 2.06268
BMP8A bone morphogenetic protein 8a 2.06268
ZNF484 zinc finger protein 484 2.05322
SLC38A4 solute carrier family 38, member 4 2.04925
TTF1 transcription termination factor, RNA polymerase I 2.0383
SMC1A structural maintenance of chromosomes 1A 2.01443
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 2.00877
MIEF1 mitochondrial elongation factor 1 2.00216

decreased expression

Symbol Name Standardized Value
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 -3.00797
BMP1 bone morphogenetic protein 1 -3.00797
TRIL TLR4 interactor with leucine-rich repeats -3.00797
EGFLAM EGF-like, fibronectin type III and laminin G domains -3.00797
CRTC2 CREB regulated transcription coactivator 2 -3.00797
ADGRD1 adhesion G protein-coupled receptor D1 -3.00797
DPCD deleted in primary ciliary dyskinesia homolog (mouse) -3.00797
FLRT1 fibronectin leucine rich transmembrane protein 1 -3.00797
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) -3.00797
ARID5A AT rich interactive domain 5A (MRF1-like) -2.93863
FAM161B family with sequence similarity 161, member B -2.93863
SCIN scinderin -2.93863
OR2B6 olfactory receptor, family 2, subfamily B, member 6 -2.93863
TSHZ1 teashirt zinc finger homeobox 1 -2.93863
TICAM1 toll-like receptor adaptor molecule 1 -2.93863
GNRHR gonadotropin-releasing hormone receptor -2.93863
C8ORF74 chromosome 8 open reading frame 74 -2.93863
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) -2.93863
GPR20 G protein-coupled receptor 20 -2.93863
OLIG1 oligodendrocyte transcription factor 1 -2.93863
TMPRSS11A transmembrane protease, serine 11A -2.93863
PCDHB13 protocadherin beta 13 -2.93863
GPR83 G protein-coupled receptor 83 -2.93863
ZNF441 zinc finger protein 441 -2.93863
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 -2.93863
BTG4 B-cell translocation gene 4 -2.93863
EMP1 epithelial membrane protein 1 -2.93863
TTLL10 tubulin tyrosine ligase-like family member 10 -2.93863
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 -2.93863
ADAP1 ArfGAP with dual PH domains 1 -2.93863
RRH retinal pigment epithelium-derived rhodopsin homolog -2.93863
LTA4H leukotriene A4 hydrolase -2.93863
KLK11 kallikrein-related peptidase 11 -2.93863
SCNN1D sodium channel, non voltage gated 1 delta subunit -2.93863
PLCD4 phospholipase C, delta 4 -2.93863
LYPD5 LY6/PLAUR domain containing 5 -2.93863
CATSPERE catsper channel auxiliary subunit epsilon -2.87497
PANK4 pantothenate kinase 4 -2.79522
HPS3 Hermansky-Pudlak syndrome 3 -2.78828
TOMM34 translocase of outer mitochondrial membrane 34 -2.74377
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli) -2.73332
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -2.64634
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 -2.64525
PICALM phosphatidylinositol binding clathrin assembly protein -2.63232
PEX13 peroxisomal biogenesis factor 13 -2.54945
TOX4 TOX high mobility group box family member 4 -2.53144
CORO1B coronin, actin binding protein, 1B -2.50986
PMPCB peptidase (mitochondrial processing) beta -2.50986
UCK1 uridine-cytidine kinase 1 -2.50032
MTA2 metastasis associated 1 family, member 2 -2.49067
BBX bobby sox homolog (Drosophila) -2.49067
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) -2.44796
ARHGAP32 Rho GTPase activating protein 32 -2.4469
AIM2 absent in melanoma 2 -2.42844
SENP1 SUMO1/sentrin specific peptidase 1 -2.41121
LENG9 leukocyte receptor cluster (LRC) member 9 -2.40622
ING4 inhibitor of growth family, member 4 -2.39274
DARS1 aspartyl-tRNA synthetase 1 -2.38301
H2BC26 H2B clustered histone 26 -2.35413
DNASE2 deoxyribonuclease II, lysosomal -2.34386
SAE1 SUMO1 activating enzyme subunit 1 -2.34372
SOX6 SRY (sex determining region Y)-box 6 -2.32421
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B -2.32421
C22ORF23 chromosome 22 open reading frame 23 -2.29801
ADGRL2 adhesion G protein-coupled receptor L2 -2.28072
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like -2.25365
KIAA1143 KIAA1143 -2.2461
LRRC17 leucine rich repeat containing 17 -2.2461
DNAAF11 dynein axonemal assembly factor 11 -2.2412
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 -2.23154
PCDHB3 protocadherin beta 3 -2.22829
CWC15 CWC15 spliceosome-associated protein -2.22829
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 -2.22452
DAGLB diacylglycerol lipase, beta -2.21858
CEP57L1 centrosomal protein 57kDa-like 1 -2.21452
LZTS1 leucine zipper, putative tumor suppressor 1 -2.21452
MDM4 MDM4, p53 regulator -2.20098
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) -2.19793
QSOX2 quiescin Q6 sulfhydryl oxidase 2 -2.19793
GNPTG N-acetylglucosamine-1-phosphate transferase, gamma subunit -2.19021
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -2.18943
TSC1 tuberous sclerosis 1 -2.1819
DDX49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 -2.1819
ZNF780B zinc finger protein 780B -2.17228
CNTNAP1 contactin associated protein 1 -2.13482
NKX3-1 NK3 homeobox 1 -2.13482
AZU1 azurocidin 1 -2.13482
H2BC5 H2B clustered histone 5 -2.13482
FAT2 FAT atypical cadherin 2 -2.13482
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5 -2.13482
MMP3 matrix metallopeptidase 3 -2.13482
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain -2.13482
ZNF485 zinc finger protein 485 -2.0982
HSDL1 hydroxysteroid dehydrogenase like 1 -2.08936
USF1 upstream transcription factor 1 -2.08037
BRPF3 bromodomain and PHD finger containing, 3 -2.07829
IL17RC interleukin 17 receptor C -2.07255
LRRC37A leucine rich repeat containing 37A -2.06635
TOM1L1 target of myb1 (chicken)-like 1 -2.06268
COL11A1 collagen, type XI, alpha 1 -2.06268
FERMT1 fermitin family member 1 -2.06264
H2BC17 H2B clustered histone 17 -2.04925
GSTM3 glutathione S-transferase mu 3 (brain) -2.04925
BEGAIN brain-enriched guanylate kinase-associated -2.04925
WIZ widely interspaced zinc finger motifs -2.04925
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta -2.04687
UBXN2A UBX domain protein 2A -2.00993
CSNK1G2 casein kinase 1, gamma 2 -2.0051