PSEN1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description presenilin 1|Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008] (NCBI Entrez Gene Database, 5663)
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Genes

370 genes differentially expressed following the PSEN1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
LIPH lipase, member H 2.42544
TRIM77 tripartite motif containing 77 2.42544
RFPL2 ret finger protein-like 2 2.42544
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.42544
OXTR oxytocin receptor 2.42544
ZNF556 zinc finger protein 556 2.42544
NLRP10 NLR family, pyrin domain containing 10 2.42544
ARRDC5 arrestin domain containing 5 2.42544
OCSTAMP osteoclast stimulatory transmembrane protein 2.42544
PRSS36 protease, serine, 36 2.42544
PLK5 polo-like kinase 5 2.42544
HCRTR2 hypocretin (orexin) receptor 2 2.42544
GPR22 G protein-coupled receptor 22 2.42544
LRG1 leucine-rich alpha-2-glycoprotein 1 2.42544
FGL2 fibrinogen-like 2 2.42544
DNASE1L2 deoxyribonuclease I-like 2 2.42544
DPEP2 dipeptidase 2 2.42544
OSGIN1 oxidative stress induced growth inhibitor 1 2.42544
RIMBP2 RIMS binding protein 2 2.42544
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.42544
OLIG3 oligodendrocyte transcription factor 3 2.42544
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 2.42544
SIGLEC5 sialic acid binding Ig-like lectin 5 2.42544
SIGLEC9 sialic acid binding Ig-like lectin 9 2.42544
LGI1 leucine-rich, glioma inactivated 1 2.42544
MISP mitotic spindle positioning 2.42544
PTCD3 pentatricopeptide repeat domain 3 2.42544
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 2.42544
LOXL4 lysyl oxidase-like 4 2.42544
NLRP6 NLR family, pyrin domain containing 6 2.42544
PF4V1 platelet factor 4 variant 1 2.42544
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 2.42544
CCDC166 coiled-coil domain containing 166 2.42544
DMRTC1 DMRT-like family C1 2.42544
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 2.42544
TRPM8 transient receptor potential cation channel, subfamily M, member 8 2.42544
LRRC74B leucine rich repeat containing 74B 2.42544
NFE2 nuclear factor, erythroid 2 2.42544
ZC2HC1B zinc finger, C2HC-type containing 1B 2.42544
C12ORF71 chromosome 12 open reading frame 71 2.42544
AIRE autoimmune regulator 2.42544
SPX spexin hormone 2.42544
SPACA5 sperm acrosome associated 5 2.42544
OIT3 oncoprotein induced transcript 3 2.42544
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 2.42544
KRTAP5-9 keratin associated protein 5-9 2.42544
RAMP3 receptor (G protein-coupled) activity modifying protein 3 2.42544
EMCN endomucin 2.42544
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 2.42544
HIGD1C HIG1 hypoxia inducible domain family, member 1C 2.42544
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.42544
SLC26A7 solute carrier family 26 (anion exchanger), member 7 2.42544
LOC122455340 uncharacterized LOC122455340 2.42544
MCHR2 melanin-concentrating hormone receptor 2 2.42544
OPRM1 opioid receptor, mu 1 2.42544
SCEL sciellin 2.42544
MYH2 myosin, heavy chain 2, skeletal muscle, adult 2.42544
ACER1 alkaline ceramidase 1 2.42544
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 2.42544
DOK2 docking protein 2, 56kDa 2.42544
GPR37L1 G protein-coupled receptor 37 like 1 2.42544
FAM228A family with sequence similarity 228, member A 2.42544
CLEC6A C-type lectin domain family 6, member A 2.42544
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 2.42544
CCDC163 CCDC163 homolog 2.42544
FLACC1 flagellum associated containing coiled-coil domains 1 2.42544
DRC2 dynein regulatory complex subunit 2 2.42544
EPCIP exosomal polycystin 1 interacting protein 2.42544
TNS1-AS1 TNS1 antisense RNA 1 2.42544
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 2.42544
CFAP90 cilia and flagella associated protein 90 2.42544
LHFPL7 LHFPL tetraspan subfamily member 7 2.42544
GARIN5B golgi associated RAB2 interactor family member 5B 2.42544
CHCT1 CHD1 helical C-terminal domain containing 1 2.42544
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.42544
ERFE erythroferrone 2.42544
SOAT2 sterol O-acyltransferase 2 2.42544
OR13H1 olfactory receptor, family 13, subfamily H, member 1 2.42544
SLC35A5 solute carrier family 35, member A5 2.42544
LGALS7B lectin, galactoside-binding, soluble, 7B 2.42544
CLDN5 claudin 5 2.42544
CCDC17 coiled-coil domain containing 17 2.42544
DMP1 dentin matrix acidic phosphoprotein 1 2.42544
CD300LG CD300 molecule-like family member g 2.42544
ERBB2 erb-b2 receptor tyrosine kinase 2 2.42544
FAM3D family with sequence similarity 3, member D 2.42544
TBX22 T-box 22 2.42544
MAP3K6 mitogen-activated protein kinase kinase kinase 6 2.42544
CFHR3 complement factor H-related 3 2.42544
IRF4 interferon regulatory factor 4 2.42544
CLEC3A C-type lectin domain family 3, member A 2.42544
GOLGA6L4 golgin A6 family-like 4 2.42544
HAL histidine ammonia-lyase 2.42544
SHC4 SHC (Src homology 2 domain containing) family, member 4 2.42544
FRK fyn-related Src family tyrosine kinase 2.42544
ALKBH6 alkB, alkylation repair homolog 6 (E. coli) 2.42544
PRR5 proline rich 5 (renal) 2.42544
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.42544
OVOL3 ovo-like zinc finger 3 2.42544
ZIC4 Zic family member 4 2.42544
CXCL16 chemokine (C-X-C motif) ligand 16 2.42544
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.42544
TPBGL trophoblast glycoprotein-like 2.42544
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like 2.42544
C9ORF64 chromosome 9 open reading frame 64 2.42544
CACTIN cactin, spliceosome C complex subunit 2.42544
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.42544
SFSWAP splicing factor, suppressor of white-apricot family 2.42544
KLF1 Kruppel-like factor 1 (erythroid) 2.42544
PGR progesterone receptor 2.42544
KLHL41 kelch-like family member 41 2.42544
TBC1D10C TBC1 domain family, member 10C 2.42544
UBXN10 UBX domain protein 10 2.42544
CRYBB3 crystallin, beta B3 2.42544
DPRX divergent-paired related homeobox 2.42544
TFB2M transcription factor B2, mitochondrial 2.42544
CSF1R colony stimulating factor 1 receptor 2.42544
UBL3 ubiquitin-like 3 2.42544
CDHR5 cadherin-related family member 5 2.42544
FATE1 fetal and adult testis expressed 1 2.42544
LYG1 lysozyme G-like 1 2.42544
C11ORF91 chromosome 11 open reading frame 91 2.42544
HHLA2 HERV-H LTR-associating 2 2.42544
GOLGA6A golgin A6 family, member A 2.42544
GOLGA6C golgin A6 family, member C 2.42544
ZIM2 zinc finger, imprinted 2 2.42544
TAT tyrosine aminotransferase 2.42544
SMIM10 small integral membrane protein 10 2.42544
CEL carboxyl ester lipase 2.42544
TIPE2 TNF alpha induced protein 8 like 2 2.42544
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 2.42544
TBX1 T-box 1 2.42544
KLK6 kallikrein-related peptidase 6 2.42544
KLK14 kallikrein-related peptidase 14 2.42544
CCDC27 coiled-coil domain containing 27 2.42544
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 2.42544
HUS1B HUS1 checkpoint homolog b (S. pombe) 2.42544
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 2.42544
SERINC4 serine incorporator 4 2.42544
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 2.42544
GPR61 G protein-coupled receptor 61 2.42544
CPA6 carboxypeptidase A6 2.42544
VAV1 vav 1 guanine nucleotide exchange factor 2.42544
CXCR5 chemokine (C-X-C motif) receptor 5 2.42544
KIFC2 kinesin family member C2 2.42544
COL6A5 collagen, type VI, alpha 5 2.42544
NLRC3 NLR family, CARD domain containing 3 2.42544
APLNR apelin receptor 2.42544
DRC1 dynein regulatory complex subunit 1 2.42544
KRT3 keratin 3, type II 2.42544
NPIPB15 nuclear pore complex interacting protein family, member B15 2.42544
ESPNL espin-like 2.42544
EDIL3 EGF-like repeats and discoidin I-like domains 3 2.42544
KRT15 keratin 15, type I 2.42544
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 2.42544
DBX2 developing brain homeobox 2 2.42544
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 2.42544
LAMB3 laminin, beta 3 2.42544
ABI3 ABI family, member 3 2.42544
DOHH deoxyhypusine hydroxylase/monooxygenase 2.42544
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 2.42544
SSC5D scavenger receptor cysteine rich family, 5 domains 2.42544
LRRC24 leucine rich repeat containing 24 2.42544
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 2.42544
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 2.42544
CHRM1 cholinergic receptor, muscarinic 1 2.42544
OR56A1 olfactory receptor, family 56, subfamily A, member 1 2.42544
PHOX2A paired-like homeobox 2a 2.42544
GPR150 G protein-coupled receptor 150 2.42544
CYBB cytochrome b-245, beta polypeptide 2.42544
GPR149 G protein-coupled receptor 149 2.42544
KRTAP5-11 keratin associated protein 5-11 2.42544
OPTC opticin 2.42544
TMEM132D transmembrane protein 132D 2.42544
SLITRK1 SLIT and NTRK-like family, member 1 2.42544
SLITRK3 SLIT and NTRK-like family, member 3 2.42544
PRSS51 protease, serine, 51 2.42544
PRSS53 protease, serine, 53 2.42544
PORCN porcupine homolog (Drosophila) 2.4226
FBXW4 F-box and WD repeat domain containing 4 2.4226
UGT8 UDP glycosyltransferase 8 2.41798
YBEY ybeY metallopeptidase (putative) 2.40923
ADAR adenosine deaminase, RNA-specific 2.40802
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) 2.38275
NKX3-1 NK3 homeobox 1 2.37579
CSNK1A1 casein kinase 1, alpha 1 2.37579
DNLZ DNL-type zinc finger 2.37579
ZNF213 zinc finger protein 213 2.37579
UPK2 uroplakin 2 2.37579
POU2AF3 POU class 2 homeobox associating factor 3 2.37579
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 2.37579
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 2.37579
PSKH1 protein serine kinase H1 2.37579
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 2.37579
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 2.37579
TET1 tet methylcytosine dioxygenase 1 2.37103
TRIM6 tripartite motif containing 6 2.35764
BTBD19 BTB (POZ) domain containing 19 2.35699
STEAP1B STEAP family member 1B 2.3224
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta 2.30565
DSE dermatan sulfate epimerase 2.26786
LSM11 LSM11, U7 small nuclear RNA associated 2.26634
VIRMA vir like m6A methyltransferase associated 2.26119
ECI1 enoyl-CoA delta isomerase 1 2.25653
ARHGAP1 Rho GTPase activating protein 1 2.25641
DUSP6 dual specificity phosphatase 6 2.25108
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 2.25108
FAM120C family with sequence similarity 120C 2.24368
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) 2.23462
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 2.20601
TCEAL9 transcription elongation factor A like 9 2.20601
ZXDC ZXD family zinc finger C 2.19302
HSPA9 heat shock 70kDa protein 9 (mortalin) 2.19021
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 2.18993
FKBP14 FK506 binding protein 14, 22 kDa 2.18993
POLN polymerase (DNA directed) nu 2.18974
H3C2 H3 clustered histone 2 2.18303
BTN2A2 butyrophilin, subfamily 2, member A2 2.1816
NUP35 nucleoporin 35kDa 2.17135
CLTB clathrin, light chain B 2.16753
APCDD1L adenomatosis polyposis coli down-regulated 1-like 2.14939
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 2.13153
UFSP2 UFM1-specific peptidase 2 2.11736
LYRM9 LYR motif containing 9 2.11736
WDR12 WD repeat domain 12 2.10901
MTRF1 mitochondrial translational release factor 1 2.10901
RERG RAS-like, estrogen-regulated, growth inhibitor 2.10736
THAP1 THAP domain containing, apoptosis associated protein 1 2.10702
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase 2.10393
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 2.09248
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 2.08154
SLC39A14 solute carrier family 39 (zinc transporter), member 14 2.08095
VCF2 VCP nuclear cofactor family member 2 2.07824
DSTN destrin (actin depolymerizing factor) 2.07087
E2F7 E2F transcription factor 7 2.07087
FSTL5 follistatin-like 5 2.04835
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4 2.04582
CEP76 centrosomal protein 76kDa 2.03932
RHOA ras homolog family member A 2.01222
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 2.01007
BCLAF3 BCLAF1 and THRAP3 family member 3 2.00211
PCTP phosphatidylcholine transfer protein 2.00211
CHD2 chromodomain helicase DNA binding protein 2 2.00211
TRPV2 transient receptor potential cation channel, subfamily V, member 2 2.00062
ATAD3C ATPase family, AAA domain containing 3C 2.00062

decreased expression

Symbol Name Standardized Value
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 -2.42544
TP73 tumor protein p73 -2.42544
ZNF284 zinc finger protein 284 -2.42544
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b -2.42544
FGF12 fibroblast growth factor 12 -2.42544
TAS2R30 taste receptor, type 2, member 30 -2.42544
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 -2.42544
EBF4 early B-cell factor 4 -2.42544
CLC Charcot-Leyden crystal galectin -2.42544
RAI2 retinoic acid induced 2 -2.42544
PSEN1 presenilin 1 -2.42544
ADAM32 ADAM metallopeptidase domain 32 -2.42544
ATP8B4 ATPase, class I, type 8B, member 4 -2.42544
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13 -2.42544
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 -2.42544
RAB3A RAB3A, member RAS oncogene family -2.42544
APLN apelin -2.42544
LYST lysosomal trafficking regulator -2.42544
NRG2 neuregulin 2 -2.42544
TXNDC9 thioredoxin domain containing 9 -2.42544
HID1 HID1 domain containing -2.42544
MROH7 maestro heat-like repeat family member 7 -2.42544
H1-1 H1.1 linker histone, cluster member -2.42544
TRAK1 trafficking protein, kinesin binding 1 -2.42544
VPS35L VPS35 endosomal protein sorting factor like -2.42544
TRIM2 tripartite motif containing 2 -2.42544
SEPTIN4 septin 4 -2.42544
TAFA4 TAFA chemokine like family member 4 -2.42544
EXD1 exonuclease 3'-5' domain containing 1 -2.42544
H4C9 H4 clustered histone 9 -2.42544
EFNB3 ephrin-B3 -2.42544
FRAT2 frequently rearranged in advanced T-cell lymphomas 2 -2.42544
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 -2.42544
DPP8 dipeptidyl-peptidase 8 -2.42544
ACVR1C activin A receptor, type IC -2.40923
SOS2 son of sevenless homolog 2 (Drosophila) -2.40923
FKBPL FK506 binding protein like -2.40586
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 -2.40586
MCRIP2 MAPK regulated corepressor interacting protein 2 -2.37829
ARSI arylsulfatase family, member I -2.37579
DNAAF1 dynein, axonemal, assembly factor 1 -2.37579
FAM186A family with sequence similarity 186, member A -2.37579
SLC15A5 solute carrier family 15, member 5 -2.37579
SH2D7 SH2 domain containing 7 -2.37579
H3C13 H3 clustered histone 13 -2.37579
CFAP157 cilia and flagella associated protein 157 -2.37579
TRA2B transformer 2 beta homolog (Drosophila) -2.37579
COL6A6 collagen, type VI, alpha 6 -2.37579
UPB1 ureidopropionase, beta -2.37579
DUSP9 dual specificity phosphatase 9 -2.37579
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3 -2.37579
PEX12 peroxisomal biogenesis factor 12 -2.37579
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 -2.37579
C1ORF167 chromosome 1 open reading frame 167 -2.37579
FAM153A family with sequence similarity 153, member A -2.37579
RB1CC1 RB1-inducible coiled-coil 1 -2.37579
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) -2.37579
C1QTNF1 C1q and tumor necrosis factor related protein 1 -2.37579
PRXL2B peroxiredoxin like 2B -2.37579
SPATC1 spermatogenesis and centriole associated 1 -2.37579
ERCC8 excision repair cross-complementation group 8 -2.37579
HAX1 HCLS1 associated protein X-1 -2.37579
C5ORF47 chromosome 5 open reading frame 47 -2.37579
GPR179 G protein-coupled receptor 179 -2.37579
PLAC8 placenta-specific 8 -2.37579
IFITM10 interferon induced transmembrane protein 10 -2.37579
ANXA1 annexin A1 -2.37579
TMEM45B transmembrane protein 45B -2.37579
ZNF333 zinc finger protein 333 -2.37579
DUOX2 dual oxidase 2 -2.37579
GSDMA gasdermin A -2.37579
ECE2 endothelin converting enzyme 2 -2.37579
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.37579
LGR6 leucine-rich repeat containing G protein-coupled receptor 6 -2.37579
PCDHGA11 protocadherin gamma subfamily A, 11 -2.37579
ELL3 elongation factor RNA polymerase II-like 3 -2.37579
CPLX1 complexin 1 -2.37579
FAM110D family with sequence similarity 110, member D -2.37579
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 -2.37579
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2 -2.37579
AKR1B15 aldo-keto reductase family 1, member B15 -2.37579
DDAH1 dimethylarginine dimethylaminohydrolase 1 -2.37451
NR2E3 nuclear receptor subfamily 2, group E, member 3 -2.37097
XRN2 5'-3' exoribonuclease 2 -2.36783
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -2.35699
PROCA1 protein interacting with cyclin A1 -2.31797
NEK6 NIMA-related kinase 6 -2.31797
PEX6 peroxisomal biogenesis factor 6 -2.3132
METTL15 methyltransferase like 15 -2.3132
PARD3B par-3 family cell polarity regulator beta -2.30565
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 -2.28068
KCTD16 potassium channel tetramerization domain containing 16 -2.27971
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -2.25108
FOXL2 forkhead box L2 -2.25108
ATXN7L2 ataxin 7-like 2 -2.25108
UVSSA UV-stimulated scaffold protein A -2.24724
PLAA phospholipase A2-activating protein -2.24093
SKIC8 SKI8 subunit of superkiller complex -2.19851
DVL1 dishevelled segment polarity protein 1 -2.19761
UBN1 ubinuclein 1 -2.19021
EGFL7 EGF-like-domain, multiple 7 -2.18993
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 -2.18993
OCIAD1 OCIA domain containing 1 -2.18993
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 -2.18768
ADCY10 adenylate cyclase 10 (soluble) -2.18703
TYMP thymidine phosphorylase -2.18703
ZNF222 zinc finger protein 222 -2.18703
TFIP11 tuftelin interacting protein 11 -2.18383
ZNF518B zinc finger protein 518B -2.18303
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial -2.16861
DORIP1 dopamine receptor interacting protein 1 -2.13625
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa -2.13153
RPL39L ribosomal protein L39-like -2.12466
ZNF774 zinc finger protein 774 -2.11591
PIM1 Pim-1 proto-oncogene, serine/threonine kinase -2.10736
RSU1 Ras suppressor protein 1 -2.10702
DLG2 discs, large homolog 2 (Drosophila) -2.07087
FAM8A1 family with sequence similarity 8, member A1 -2.06594
MTA1 metastasis associated 1 -2.05122
FAM162A family with sequence similarity 162, member A -2.04582
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -2.04092
COTL1 coactosin-like F-actin binding protein 1 -2.03932
RNH1 ribonuclease/angiogenin inhibitor 1 -2.03537
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 -2.03537
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha -2.02287