| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | presenilin 1|Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008] (NCBI Entrez Gene Database, 5663) |
| External Link | https://ncbi.nlm.nih.gov/gene/5663 |
| Similar Terms | |
| Downloads & Tools |
500 genes differentially expressed following the PSEN1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.0250635 |
| MAP7 | microtubule-associated protein 7 | 0.0234503 |
| CA2 | carbonic anhydrase II | 0.021959 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0176782 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.0174946 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | 0.0169455 |
| RGCC | regulator of cell cycle | 0.0167294 |
| AQP3 | aquaporin 3 (Gill blood group) | 0.0163457 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0154305 |
| KRT17 | keratin 17, type I | 0.0149388 |
| HOPX | HOP homeobox | 0.0138396 |
| ADIRF | adipogenesis regulatory factor | 0.0138182 |
| TXLNA | taxilin alpha | 0.0136146 |
| FABP4 | fatty acid binding protein 4, adipocyte | 0.0134647 |
| HSPB8 | heat shock 22kDa protein 8 | 0.0130738 |
| KRT14 | keratin 14, type I | 0.0129862 |
| ANOS1 | anosmin 1 | 0.0129854 |
| SOWAHC | sosondowah ankyrin repeat domain family member C | 0.0122628 |
| TBX3 | T-box 3 | 0.012089 |
| CLIC5 | chloride intracellular channel 5 | 0.0119231 |
| EGR2 | early growth response 2 | 0.0117576 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0117453 |
| TPD52 | tumor protein D52 | 0.0116962 |
| RGS5 | regulator of G-protein signaling 5 | 0.0114895 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0112505 |
| MMP1 | matrix metallopeptidase 1 | 0.0110145 |
| MET | MET proto-oncogene, receptor tyrosine kinase | 0.0109734 |
| LAMB3 | laminin, beta 3 | 0.0109642 |
| ITGA6 | integrin, alpha 6 | 0.0108538 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.010659 |
| XPO7 | exportin 7 | 0.0106191 |
| AQP1 | aquaporin 1 (Colton blood group) | 0.0104812 |
| SIK1 | salt-inducible kinase 1 | 0.0104465 |
| DDX21 | DEAD (Asp-Glu-Ala-Asp) box helicase 21 | 0.0102955 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.010213 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | 0.0101902 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0100305 |
| TSPAN3 | tetraspanin 3 | 0.00992865 |
| SEMA6A | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A | 0.00992787 |
| SFN | stratifin | 0.00989682 |
| SEC14L1 | SEC14-like 1 (S. cerevisiae) | 0.00988753 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | 0.00984165 |
| SPARCL1 | SPARC-like 1 (hevin) | 0.00979865 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | 0.0097727 |
| ABLIM1 | actin binding LIM protein 1 | 0.0097647 |
| RBM34 | RNA binding motif protein 34 | 0.00970572 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.00969325 |
| HK1 | hexokinase 1 | 0.00966816 |
| SPON1 | spondin 1, extracellular matrix protein | 0.00966429 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.00965958 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.00958259 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.0095305 |
| TENT4A | terminal nucleotidyltransferase 4A | 0.00947138 |
| CPA3 | carboxypeptidase A3 (mast cell) | 0.00944098 |
| PIK3C2B | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta | 0.00939968 |
| STK10 | serine/threonine kinase 10 | 0.00934046 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.00932066 |
| SEPTIN10 | septin 10 | 0.00931856 |
| A2M | alpha-2-macroglobulin | 0.0092003 |
| GREM1 | gremlin 1, DAN family BMP antagonist | 0.00920008 |
| FZD5 | frizzled class receptor 5 | 0.00918274 |
| PCDH17 | protocadherin 17 | 0.00908018 |
| SH3BP4 | SH3-domain binding protein 4 | 0.00905127 |
| PPL | periplakin | 0.00900154 |
| MX1 | MX dynamin-like GTPase 1 | 0.00892284 |
| MYO1B | myosin IB | 0.00891065 |
| PRDX2 | peroxiredoxin 2 | 0.00884719 |
| GUSBP3 | glucuronidase, beta pseudogene 3 | 0.00881985 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.00880635 |
| MYO1D | myosin ID | 0.00875 |
| HNRNPAB | heterogeneous nuclear ribonucleoprotein A/B | 0.00872644 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.00870363 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0086766 |
| BMP2 | bone morphogenetic protein 2 | 0.00863978 |
| MMP3 | matrix metallopeptidase 3 | 0.00863553 |
| MGLL | monoglyceride lipase | 0.00861884 |
| STIP1 | stress-induced phosphoprotein 1 | 0.00858677 |
| MAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog | 0.00855655 |
| IFI44L | interferon-induced protein 44-like | 0.00851225 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | 0.0084216 |
| PODXL | podocalyxin-like | 0.00841423 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.00840959 |
| ASPH | aspartate beta-hydroxylase | 0.00839786 |
| TGFB3 | transforming growth factor, beta 3 | 0.00838043 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.00837116 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0083706 |
| CPE | carboxypeptidase E | 0.00832723 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.00829418 |
| FSTL1 | follistatin-like 1 | 0.00828567 |
| MSN | moesin | 0.00826203 |
| SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) | 0.00824903 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | 0.00823787 |
| CHN1 | chimerin 1 | 0.00823501 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.00816194 |
| NAV2 | neuron navigator 2 | 0.00815285 |
| TNS1 | tensin 1 | 0.00814063 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.00811643 |
| CHGB | chromogranin B | 0.00810432 |
| RREB1 | ras responsive element binding protein 1 | 0.00806227 |
| MXRA5 | matrix-remodelling associated 5 | 0.00806126 |
| PI3 | peptidase inhibitor 3, skin-derived | 0.00803734 |
| GABRE | gamma-aminobutyric acid (GABA) A receptor, epsilon | 0.00803212 |
| MCL1 | myeloid cell leukemia 1 | 0.00802103 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.00800975 |
| ALDH5A1 | aldehyde dehydrogenase 5 family, member A1 | 0.0079969 |
| FERMT1 | fermitin family member 1 | 0.00797458 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 0.00793759 |
| TFRC | transferrin receptor | 0.00792142 |
| PMP22 | peripheral myelin protein 22 | 0.00791025 |
| WFDC1 | WAP four-disulfide core domain 1 | 0.0079034 |
| LEPROTL1 | leptin receptor overlapping transcript-like 1 | 0.0078888 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | 0.00788054 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.00787144 |
| TSPAN8 | tetraspanin 8 | 0.00782174 |
| COL15A1 | collagen, type XV, alpha 1 | 0.00776021 |
| CALML3 | calmodulin-like 3 | 0.00775957 |
| COL4A5 | collagen, type IV, alpha 5 | 0.00775348 |
| MEIS1 | Meis homeobox 1 | 0.00774488 |
| ADAR | adenosine deaminase, RNA-specific | 0.00772587 |
| IL13RA2 | interleukin 13 receptor, alpha 2 | 0.00769089 |
| LAMC2 | laminin, gamma 2 | 0.00768018 |
| FNDC3B | fibronectin type III domain containing 3B | 0.00766063 |
| CYP26B1 | cytochrome P450, family 26, subfamily B, polypeptide 1 | 0.00765409 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.00765101 |
| IRAK1 | interleukin-1 receptor-associated kinase 1 | 0.00762222 |
| CLCA4 | chloride channel accessory 4 | 0.00760903 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | 0.00759107 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.00758145 |
| ACKR3 | atypical chemokine receptor 3 | 0.00757673 |
| SPOCK2 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 | 0.00756753 |
| LAPTM4B | lysosomal protein transmembrane 4 beta | 0.00751729 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | 0.00746553 |
| SDC4 | syndecan 4 | 0.00744166 |
| BTG3 | BTG family, member 3 | 0.00743151 |
| IVNS1ABP | influenza virus NS1A binding protein | 0.00741547 |
| SPRR1B | small proline-rich protein 1B | 0.007414 |
| ITSN1 | intersectin 1 (SH3 domain protein) | 0.0073678 |
| RIN2 | Ras and Rab interactor 2 | 0.00735802 |
| IRS2 | insulin receptor substrate 2 | 0.00732497 |
| SDHA | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) | 0.00731509 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.00729324 |
| DAAM2 | dishevelled associated activator of morphogenesis 2 | 0.00729153 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | 0.00728619 |
| TFAP2A | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) | 0.0072825 |
| ITPKB | inositol-trisphosphate 3-kinase B | 0.00727379 |
| EZR | ezrin | 0.00727163 |
| TP63 | tumor protein p63 | 0.00726625 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.00726515 |
| ARHGEF18 | Rho/Rac guanine nucleotide exchange factor (GEF) 18 | 0.00726134 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.00723639 |
| LARP1 | La ribonucleoprotein domain family, member 1 | 0.007194 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.00718934 |
| HSPA1A | heat shock 70kDa protein 1A | 0.00717213 |
| TRIM14 | tripartite motif containing 14 | 0.00716578 |
| S100A2 | S100 calcium binding protein A2 | 0.00716353 |
| SPRR1A | small proline-rich protein 1A | 0.00715727 |
| MAOB | monoamine oxidase B | 0.0071567 |
| MEN1 | multiple endocrine neoplasia I | 0.00714812 |
| SEPTIN2 | septin 2 | 0.00713691 |
| VPS28 | vacuolar protein sorting 28 homolog (S. cerevisiae) | 0.00713445 |
| NDNF | neuron-derived neurotrophic factor | 0.0071334 |
| SNAI2 | snail family zinc finger 2 | 0.00710853 |
| FCGBP | Fc fragment of IgG binding protein | 0.00710173 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.00708517 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.00707147 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | 0.0070578 |
| GSDMB | gasdermin B | 0.00705065 |
| TUBA4A | tubulin, alpha 4a | 0.00704668 |
| PDZD2 | PDZ domain containing 2 | 0.00703847 |
| PDLIM1 | PDZ and LIM domain 1 | 0.00703837 |
| SYNPO | synaptopodin | 0.00702998 |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 | 0.00702093 |
| NBPF10 | neuroblastoma breakpoint family, member 10 | 0.00700721 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.00699562 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.00698558 |
| KIAA0125 | KIAA0125 | 0.00698247 |
| FN1 | fibronectin 1 | 0.00697456 |
| CDH5 | cadherin 5, type 2 (vascular endothelium) | 0.00697293 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.00696604 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | 0.00694451 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.00694331 |
| ZNF395 | zinc finger protein 395 | 0.0069387 |
| GRB7 | growth factor receptor-bound protein 7 | 0.00693731 |
| KLF6 | Kruppel-like factor 6 | 0.00690771 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | 0.00686307 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.00685143 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.00685084 |
| NUP85 | nucleoporin 85kDa | 0.00685082 |
| SLC2A5 | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 | 0.00683925 |
| FKBP4 | FK506 binding protein 4, 59kDa | 0.00682002 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.00681345 |
| FZD10 | frizzled class receptor 10 | 0.00681206 |
| MMP10 | matrix metallopeptidase 10 | 0.00677833 |
| PDGFD | platelet derived growth factor D | 0.00677334 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.00677309 |
| KRT16 | keratin 16, type I | 0.00676598 |
| CBX1 | chromobox homolog 1 | 0.00676548 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | 0.00675378 |
| DDX39A | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A | 0.00674962 |
| AGT | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | 0.00674865 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.00674779 |
| ABCA8 | ATP-binding cassette, sub-family A (ABC1), member 8 | 0.00673936 |
| SYNM | synemin, intermediate filament protein | 0.00673606 |
| DKC1 | dyskeratosis congenita 1, dyskerin | 0.00670814 |
| NIT1 | nitrilase 1 | 0.00670591 |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | 0.00669919 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0066989 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.00669543 |
| BCAP31 | B-cell receptor-associated protein 31 | 0.00669341 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.00668935 |
| PRNP | prion protein | 0.00668827 |
| KRT1 | keratin 1, type II | 0.00668486 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.00668254 |
| CYTH1 | cytohesin 1 | 0.00666441 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | 0.00666088 |
| VWF | von Willebrand factor | 0.00665512 |
| NPIPB3 | nuclear pore complex interacting protein family, member B3 | 0.00665281 |
| CXCR4 | chemokine (C-X-C motif) receptor 4 | 0.00664819 |
| SLC16A6 | solute carrier family 16, member 6 | 0.00664407 |
| RAB8A | RAB8A, member RAS oncogene family | 0.00664126 |
| HBEGF | heparin-binding EGF-like growth factor | 0.00663501 |
| EGFL6 | EGF-like-domain, multiple 6 | 0.00663059 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.00661915 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.00661862 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.00660295 |
| FLT1 | fms-related tyrosine kinase 1 | 0.00659383 |
| RPL10 | ribosomal protein L10 | 0.00657975 |
| MXI1 | MAX interactor 1, dimerization protein | 0.00657197 |
| TASOR2 | transcription activation suppressor family member 2 | 0.00656915 |
| FOXF1 | forkhead box F1 | 0.00656809 |
| KRT6B | keratin 6B, type II | 0.00656532 |
| PRKD2 | protein kinase D2 | 0.00654311 |
| PRPF3 | pre-mRNA processing factor 3 | 0.00654056 |
| FBLN2 | fibulin 2 | 0.00653919 |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | 0.0065384 |
| RGS1 | regulator of G-protein signaling 1 | 0.00653483 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0065334 |
| DCTN4 | dynactin 4 (p62) | 0.00652361 |
| PLS3 | plastin 3 | 0.00652033 |
| AKAP8 | A kinase (PRKA) anchor protein 8 | 0.00651874 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0065087 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.00648843 |
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase | 0.0064859 |
| EMP1 | epithelial membrane protein 1 | 0.00646463 |
| CELSR1 | cadherin, EGF LAG seven-pass G-type receptor 1 | 0.00645172 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.00644492 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | 0.00644205 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.00641771 |
| CRABP2 | cellular retinoic acid binding protein 2 | 0.00640007 |
| DST | dystonin | 0.00639474 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPB1 | heat shock 27kDa protein 1 | -0.0190518 |
| LTF | lactotransferrin | -0.0153113 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | -0.0143691 |
| MAL | mal, T-cell differentiation protein | -0.0140817 |
| PENK | proenkephalin | -0.0140043 |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | -0.0122527 |
| FCN1 | ficolin (collagen/fibrinogen domain containing) 1 | -0.0118514 |
| METRN | meteorin, glial cell differentiation regulator | -0.0117015 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -0.0116947 |
| ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) | -0.0113654 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0113601 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.0110409 |
| S100A8 | S100 calcium binding protein A8 | -0.0110109 |
| NPC2 | Niemann-Pick disease, type C2 | -0.0107885 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0106339 |
| E2F2 | E2F transcription factor 2 | -0.0104585 |
| LCN2 | lipocalin 2 | -0.0104112 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0103455 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0101715 |
| PCP4 | Purkinje cell protein 4 | -0.0100714 |
| PLBD1 | phospholipase B domain containing 1 | -0.0095891 |
| CD1E | CD1e molecule | -0.0095834 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.00957619 |
| ZBTB18 | zinc finger and BTB domain containing 18 | -0.009567 |
| ADD3 | adducin 3 (gamma) | -0.00956411 |
| RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 | -0.00955952 |
| SH3TC1 | SH3 domain and tetratricopeptide repeats 1 | -0.00950598 |
| RGS10 | regulator of G-protein signaling 10 | -0.00945075 |
| TESC | tescalcin | -0.00944977 |
| CD4 | CD4 molecule | -0.00935536 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0093469 |
| S100A9 | S100 calcium binding protein A9 | -0.00934082 |
| CSTA | cystatin A (stefin A) | -0.00919744 |
| FXYD2 | FXYD domain containing ion transport regulator 2 | -0.00917237 |
| HOXC6 | homeobox C6 | -0.00915592 |
| TXNIP | thioredoxin interacting protein | -0.00914572 |
| FGL2 | fibrinogen-like 2 | -0.00914317 |
| MLF1 | myeloid leukemia factor 1 | -0.00909368 |
| S100P | S100 calcium binding protein P | -0.0090294 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | -0.00899477 |
| LST1 | leukocyte specific transcript 1 | -0.00890556 |
| RGS4 | regulator of G-protein signaling 4 | -0.00889784 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.00887236 |
| TBC1D9 | TBC1 domain family, member 9 (with GRAM domain) | -0.0088225 |
| C1ORF54 | chromosome 1 open reading frame 54 | -0.00879694 |
| CFP | complement factor properdin | -0.00878028 |
| DLK1 | delta-like 1 homolog (Drosophila) | -0.00873937 |
| IDH2 | isocitrate dehydrogenase 2 (NADP+), mitochondrial | -0.00871205 |
| EPHX1 | epoxide hydrolase 1, microsomal (xenobiotic) | -0.0086826 |
| ATP5G2 | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9) | -0.00859064 |
| LILRA2 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 | -0.00857246 |
| FAM162A | family with sequence similarity 162, member A | -0.00855114 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | -0.00850847 |
| PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta | -0.00850057 |
| GALNT1 | polypeptide N-acetylgalactosaminyltransferase 1 | -0.00836949 |
| CLEC11A | C-type lectin domain family 11, member A | -0.00836225 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | -0.00835492 |
| MRPL40 | mitochondrial ribosomal protein L40 | -0.00830583 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | -0.00830101 |
| NTS | neurotensin | -0.00827867 |
| ICAM2 | intercellular adhesion molecule 2 | -0.00827701 |
| GTPBP8 | GTP-binding protein 8 (putative) | -0.00823877 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.00819787 |
| CALB1 | calbindin 1, 28kDa | -0.00816441 |
| CPVL | carboxypeptidase, vitellogenic-like | -0.0081078 |
| COMMD8 | COMM domain containing 8 | -0.00806904 |
| CST3 | cystatin C | -0.00804483 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | -0.00804226 |
| VTCN1 | V-set domain containing T cell activation inhibitor 1 | -0.00799215 |
| NID2 | nidogen 2 (osteonidogen) | -0.00797203 |
| PAN2 | PAN2 poly(A) specific ribonuclease subunit | -0.00793452 |
| CYP2E1 | cytochrome P450, family 2, subfamily E, polypeptide 1 | -0.00792287 |
| NMU | neuromedin U | -0.00791708 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -0.00791586 |
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | -0.00787034 |
| WFDC2 | WAP four-disulfide core domain 2 | -0.00785277 |
| MGP | matrix Gla protein | -0.00784249 |
| METTL7A | methyltransferase like 7A | -0.00783697 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -0.00783426 |
| ACOX2 | acyl-CoA oxidase 2, branched chain | -0.0078148 |
| SCN3A | sodium channel, voltage gated, type III alpha subunit | -0.00779444 |
| PDP1 | pyruvate dehyrogenase phosphatase catalytic subunit 1 | -0.00777042 |
| AIP | aryl hydrocarbon receptor interacting protein | -0.00775431 |
| DEPTOR | DEP domain containing MTOR-interacting protein | -0.00771001 |
| NME4 | NME/NM23 nucleoside diphosphate kinase 4 | -0.007685 |
| LYRM4 | LYR motif containing 4 | -0.00767972 |
| DNTT | DNA nucleotidylexotransferase | -0.0076682 |
| ANO3 | anoctamin 3 | -0.00766368 |
| NRN1 | neuritin 1 | -0.00766273 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.00763059 |
| GTF2H5 | general transcription factor IIH, polypeptide 5 | -0.00761261 |
| TSPYL5 | TSPY-like 5 | -0.00758826 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.00751686 |
| PEG3 | paternally expressed 3 | -0.00746275 |
| HDDC2 | HD domain containing 2 | -0.00745077 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | -0.00744686 |
| CD2 | CD2 molecule | -0.00742625 |
| HLA-DOB | major histocompatibility complex, class II, DO beta | -0.00739387 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | -0.00736342 |
| RBX1 | ring-box 1, E3 ubiquitin protein ligase | -0.00736171 |
| PRKCQ | protein kinase C, theta | -0.00734934 |
| FAM171A1 | family with sequence similarity 171, member A1 | -0.00734377 |
| CAPN6 | calpain 6 | -0.00730731 |
| ATP5MJ | ATP synthase membrane subunit j | -0.00728426 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | -0.00727652 |
| KYNU | kynureninase | -0.00725917 |
| C12ORF29 | chromosome 12 open reading frame 29 | -0.00725788 |
| ZNF226 | zinc finger protein 226 | -0.00725163 |
| TPD52L1 | tumor protein D52-like 1 | -0.00725084 |
| IFT20 | intraflagellar transport 20 | -0.0072377 |
| LYZ | lysozyme | -0.00722979 |
| VCAN | versican | -0.00722829 |
| PADI2 | peptidyl arginine deiminase, type II | -0.00718187 |
| ADAP1 | ArfGAP with dual PH domains 1 | -0.00716948 |
| MYL6B | myosin, light chain 6B, alkali, smooth muscle and non-muscle | -0.00716456 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | -0.00715023 |
| MRPL33 | mitochondrial ribosomal protein L33 | -0.00713959 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.00712044 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.00709348 |
| C6ORF48 | chromosome 6 open reading frame 48 | -0.00708442 |
| WASHC3 | WASH complex subunit 3 | -0.00706732 |
| NRGN | neurogranin (protein kinase C substrate, RC3) | -0.00706308 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0070415 |
| CD1B | CD1b molecule | -0.00702655 |
| CRLF1 | cytokine receptor-like factor 1 | -0.00699065 |
| NR2F2 | nuclear receptor subfamily 2, group F, member 2 | -0.00698283 |
| DCXR | dicarbonyl/L-xylulose reductase | -0.00697986 |
| APOC2 | apolipoprotein C-II | -0.00697268 |
| AIF1 | allograft inflammatory factor 1 | -0.00697027 |
| RPS5 | ribosomal protein S5 | -0.00694458 |
| NDUFA3 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa | -0.00691237 |
| PFDN5 | prefoldin subunit 5 | -0.00691111 |
| LY86 | lymphocyte antigen 86 | -0.00690745 |
| MRPL23 | mitochondrial ribosomal protein L23 | -0.00689625 |
| PACSIN3 | protein kinase C and casein kinase substrate in neurons 3 | -0.00688373 |
| FHIT | fragile histidine triad | -0.00687649 |
| RPS27L | ribosomal protein S27-like | -0.00687324 |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | -0.00687253 |
| COX7A2L | cytochrome c oxidase subunit VIIa polypeptide 2 like | -0.00687232 |
| IL2RG | interleukin 2 receptor, gamma | -0.00686783 |
| NIPSNAP2 | nipsnap homolog 2 | -0.00685092 |
| LSM1 | LSM1, U6 small nuclear RNA associated | -0.00682705 |
| SELENOW | selenoprotein W | -0.00682118 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | -0.00682023 |
| FKBP1B | FK506 binding protein 1B, 12.6 kDa | -0.00681746 |
| CRYL1 | crystallin, lambda 1 | -0.00678805 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.00678793 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | -0.00678494 |
| STK39 | serine threonine kinase 39 | -0.00676562 |
| PRKCB | protein kinase C, beta | -0.006745 |
| BST1 | bone marrow stromal cell antigen 1 | -0.00674016 |
| RASGRP1 | RAS guanyl releasing protein 1 (calcium and DAG-regulated) | -0.0067373 |
| FPR1 | formyl peptide receptor 1 | -0.00673017 |
| TSPAN6 | tetraspanin 6 | -0.00672478 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.00672062 |
| PHYH | phytanoyl-CoA 2-hydroxylase | -0.00671406 |
| SYNGR3 | synaptogyrin 3 | -0.006711 |
| TMEM14B | transmembrane protein 14B | -0.00671002 |
| CD3D | CD3d molecule, delta (CD3-TCR complex) | -0.00668265 |
| TIMM8B | translocase of inner mitochondrial membrane 8 homolog B (yeast) | -0.00664372 |
| PTGES | prostaglandin E synthase | -0.00664334 |
| ANXA6 | annexin A6 | -0.00664265 |
| RAG1 | recombination activating gene 1 | -0.00663828 |
| MYT1L | myelin transcription factor 1-like | -0.00663487 |
| MS4A6A | membrane-spanning 4-domains, subfamily A, member 6A | -0.00662954 |
| R3HDM2 | R3H domain containing 2 | -0.00662511 |
| EFNB3 | ephrin-B3 | -0.00661978 |
| HCK | HCK proto-oncogene, Src family tyrosine kinase | -0.00659536 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | -0.00659283 |
| ABHD11 | abhydrolase domain containing 11 | -0.00659083 |
| PEG10 | paternally expressed 10 | -0.00657779 |
| THYN1 | thymocyte nuclear protein 1 | -0.00657684 |
| IFI30 | interferon, gamma-inducible protein 30 | -0.00657451 |
| MRPL57 | mitochondrial ribosomal protein L57 | -0.00656083 |
| SLC27A5 | solute carrier family 27 (fatty acid transporter), member 5 | -0.00655563 |
| TSPAN31 | tetraspanin 31 | -0.00655174 |
| EHHADH | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | -0.00654756 |
| LIPT1 | lipoyltransferase 1 | -0.00652256 |
| CD8A | CD8a molecule | -0.00649312 |
| VAV3 | vav 3 guanine nucleotide exchange factor | -0.00648997 |
| TNNT1 | troponin T type 1 (skeletal, slow) | -0.0064755 |
| PITX3 | paired-like homeodomain 3 | -0.00646516 |
| IFT52 | intraflagellar transport 52 | -0.00645549 |
| CYRIA | CYFIP related Rac1 interactor A | -0.0064101 |
| C9ORF16 | chromosome 9 open reading frame 16 | -0.00640033 |
| SLC25A11 | solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 | -0.00638969 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | -0.00638702 |
| CNIH1 | cornichon family AMPA receptor auxiliary protein 1 | -0.00637576 |
| CA12 | carbonic anhydrase XII | -0.00635735 |
| S100A12 | S100 calcium binding protein A12 | -0.00634284 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | -0.00634051 |
| CCP110 | centriolar coiled coil protein 110kDa | -0.00633154 |
| APIP | APAF1 interacting protein | -0.00631385 |
| NAT1 | N-acetyltransferase 1 (arylamine N-acetyltransferase) | -0.00629631 |
| H1-0 | H1.0 linker histone | -0.00629511 |
| GLB1L2 | galactosidase, beta 1-like 2 | -0.00629276 |
| NME5 | NME/NM23 family member 5 | -0.00629223 |
| HLA-DMB | major histocompatibility complex, class II, DM beta | -0.00628943 |
| LRRC17 | leucine rich repeat containing 17 | -0.00628518 |
| RWDD1 | RWD domain containing 1 | -0.00628159 |
| EAPP | E2F-associated phosphoprotein | -0.00625757 |
| MEG3 | maternally expressed 3 (non-protein coding) | -0.00624121 |
| ITGA4 | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | -0.0062394 |
| WDR61 | WD repeat domain 61 | -0.00623348 |
| AGR2 | anterior gradient 2 | -0.00623044 |
| TP53TG1 | TP53 target 1 (non-protein coding) | -0.00622964 |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | -0.00621149 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.00620828 |
| POLB | polymerase (DNA directed), beta | -0.00620343 |
| MYB | v-myb avian myeloblastosis viral oncogene homolog | -0.00619786 |
| KRCC1 | lysine-rich coiled-coil 1 | -0.00618881 |
| SESN1 | sestrin 1 | -0.00618562 |
| ANTKMT | adenine nucleotide translocase lysine methyltransferase | -0.00617988 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | -0.00617886 |
| DYRK4 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 | -0.00617705 |
| BMP4 | bone morphogenetic protein 4 | -0.00617388 |
| H1-10 | H1.10 linker histone | -0.0061685 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.00616654 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | -0.00616358 |
| EMC9 | ER membrane protein complex subunit 9 | -0.00616288 |
| ZNF277 | zinc finger protein 277 | -0.00615926 |
| THOC7 | THO complex 7 | -0.00615473 |
| GUCY2C | guanylate cyclase 2C | -0.00614721 |
| TRAPPC2L | trafficking protein particle complex 2-like | -0.00613416 |
| RWDD2B | RWD domain containing 2B | -0.00611967 |
| COPS7A | COP9 signalosome subunit 7A | -0.0061098 |
| ITM2A | integral membrane protein 2A | -0.0060706 |
| NUDT11 | nudix (nucleoside diphosphate linked moiety X)-type motif 11 | -0.00606699 |
| CETN2 | centrin, EF-hand protein, 2 | -0.00606443 |
| AKR7A3 | aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) | -0.00603578 |
| CCDC59 | coiled-coil domain containing 59 | -0.00603072 |
| NEK2 | NIMA-related kinase 2 | -0.00602118 |
| LIN7A | lin-7 homolog A (C. elegans) | -0.0060175 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.00601666 |
| TMX4 | thioredoxin-related transmembrane protein 4 | -0.00600589 |
| STK38L | serine/threonine kinase 38 like | -0.00600534 |
| ERAP2 | endoplasmic reticulum aminopeptidase 2 | -0.00600202 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | -0.00600002 |
| RDH11 | retinol dehydrogenase 11 (all-trans/9-cis/11-cis) | -0.00599992 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.00599178 |
| ATP5MF | ATP synthase membrane subunit f | -0.00598366 |
| FGG | fibrinogen gamma chain | -0.00598247 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -0.00598057 |
| POLR2G | polymerase (RNA) II (DNA directed) polypeptide G | -0.00597437 |
| GNG7 | guanine nucleotide binding protein (G protein), gamma 7 | -0.00597035 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0059597 |
| PIN1 | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | -0.00595901 |
| APOC1 | apolipoprotein C-I | -0.00595857 |
| ARL6IP5 | ADP-ribosylation factor-like 6 interacting protein 5 | -0.00595489 |
| FCER1G | Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide | -0.00592901 |
