PSENEN Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description presenilin enhancer gamma secretase subunit|Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] (NCBI Entrez Gene Database, 55851)
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Genes

312 genes differentially expressed following the PSENEN gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ZNF208 zinc finger protein 208 3.0363
CCL5 chemokine (C-C motif) ligand 5 3.0363
PAX5 paired box 5 3.0363
RSPO1 R-spondin 1 3.0363
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide 3.0363
SFXN3 sideroflexin 3 3.0363
MFAP4 microfibrillar-associated protein 4 3.0363
NUGGC nuclear GTPase, germinal center associated 3.0363
GPR21 G protein-coupled receptor 21 3.0363
TM4SF20 transmembrane 4 L six family member 20 3.0363
SOX18 SRY (sex determining region Y)-box 18 3.0363
CELF6 CUGBP, Elav-like family member 6 3.0363
EGFL8 EGF-like-domain, multiple 8 3.0363
CABP4 calcium binding protein 4 3.0363
NANOS3 nanos homolog 3 (Drosophila) 3.0363
ZFP57 ZFP57 zinc finger protein 3.0363
TSGA13 testis specific, 13 3.0363
PKP1 plakophilin 1 3.0363
SOX14 SRY (sex determining region Y)-box 14 3.0363
RFPL3 ret finger protein-like 3 3.0363
NOTUM notum pectinacetylesterase homolog (Drosophila) 3.0363
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 3.0363
TPPP tubulin polymerization promoting protein 3.0363
SPAG6 sperm associated antigen 6 3.0363
FAM9B family with sequence similarity 9, member B 3.0363
WAS Wiskott-Aldrich syndrome 3.0363
ELL2 elongation factor, RNA polymerase II, 2 3.0363
RBP4 retinol binding protein 4, plasma 3.0363
ZC2HC1B zinc finger, C2HC-type containing 1B 3.0363
CD34 CD34 molecule 3.0363
CRYAA crystallin, alpha A 3.0363
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 3.0363
TDRD9 tudor domain containing 9 3.0363
LRRC10B leucine rich repeat containing 10B 3.0363
ZNF324 zinc finger protein 324 3.0363
RLN3 relaxin 3 3.0363
MUC22 mucin 22 3.0363
PRDM16 PR domain containing 16 3.0363
MYO16 myosin XVI 3.0363
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 3.0363
AMPD1 adenosine monophosphate deaminase 1 3.0363
OR52H1 olfactory receptor, family 52, subfamily H, member 1 3.0363
FAM90A11 family with sequence similarity 90 member A11 3.0363
CLXN calaxin 3.0363
CCN5 cellular communication network factor 5 3.0363
DEFB108B defensin, beta 108B 3.0363
LTB4R2 leukotriene B4 receptor 2 3.0363
ALX4 ALX homeobox 4 3.0363
OTOR otoraplin 3.0363
SPRR2G small proline-rich protein 2G 3.0363
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 3.0363
CASTOR1 cytosolic arginine sensor for mTORC1 subunit 1 3.0363
GARIN6 golgi associated RAB2 interactor family member 6 3.0363
SPMIP10 sperm microtubule inner protein 10 3.0363
REELD1 reeler domain containing 1 3.0363
TEX54 testis expressed 54 3.0363
MUCL3 mucin like 3 3.0363
ARMH2 armadillo like helical domain containing 2 3.0363
CFAP299 cilia and flagella associated protein 299 3.0363
H2BW2 H2B.W histone 2 3.0363
TEX13C TEX13 family member C 3.0363
CYLC2 cylicin, basic protein of sperm head cytoskeleton 2 3.0363
ASB4 ankyrin repeat and SOCS box containing 4 3.0363
REP15 RAB15 effector protein 3.0363
TUBA3C tubulin, alpha 3c 3.0363
ARL5C ADP-ribosylation factor-like 5C 3.0363
PTPRH protein tyrosine phosphatase, receptor type, H 3.0363
PTPRC protein tyrosine phosphatase, receptor type, C 3.0363
PTPRQ protein tyrosine phosphatase, receptor type, Q 3.0363
ANGPT1 angiopoietin 1 3.0363
ZACN zinc activated ligand-gated ion channel 3.0363
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 3.0363
NXPE2 neurexophilin and PC-esterase domain family, member 2 3.0363
MRPL4 mitochondrial ribosomal protein L4 3.0363
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 3.0363
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 3.0363
WNT9B wingless-type MMTV integration site family, member 9B 3.0363
CCR3 chemokine (C-C motif) receptor 3 3.0363
NPFF neuropeptide FF-amide peptide precursor 3.0363
SPDYC speedy/RINGO cell cycle regulator family member C 3.0363
C12ORF54 chromosome 12 open reading frame 54 3.0363
DNASE2B deoxyribonuclease II beta 3.0363
USP26 ubiquitin specific peptidase 26 3.0363
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 3.0363
CPA2 carboxypeptidase A2 (pancreatic) 3.0363
FAM177B family with sequence similarity 177, member B 3.0363
TDRD10 tudor domain containing 10 3.0363
ADAM8 ADAM metallopeptidase domain 8 3.0363
WFDC6 WAP four-disulfide core domain 6 3.0363
KLF1 Kruppel-like factor 1 (erythroid) 3.0363
TNR tenascin R 3.0363
CLEC4D C-type lectin domain family 4, member D 3.0363
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 3.0363
ZNF541 zinc finger protein 541 3.0363
GP2 glycoprotein 2 (zymogen granule membrane) 3.0363
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 3.0363
RBMXL2 RNA binding motif protein, X-linked-like 2 3.0363
RPA4 replication protein A4, 30kDa 3.0363
ERMN ermin, ERM-like protein 3.0363
PLA2G4E phospholipase A2, group IVE 3.0363
CGB7 chorionic gonadotropin, beta polypeptide 7 3.0363
DRD5 dopamine receptor D5 3.0363
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 3.0363
CCNA1 cyclin A1 3.0363
LAMB3 laminin, beta 3 3.0363
MEIS1 Meis homeobox 1 3.0363
OR8J1 olfactory receptor, family 8, subfamily J, member 1 3.0363
GPR142 G protein-coupled receptor 142 3.0363
POU4F3 POU class 4 homeobox 3 3.0363
LRRC24 leucine rich repeat containing 24 3.0363
LHX5 LIM homeobox 5 3.0363
PGR progesterone receptor 3.0363
DAPL1 death associated protein-like 1 3.0363
PRR35 proline rich 35 3.0363
HK3 hexokinase 3 (white cell) 3.0363
KDM2A lysine (K)-specific demethylase 2A 3.0363
FAM135B family with sequence similarity 135, member B 3.0363
KRT15 keratin 15, type I 3.0363
CCL15 chemokine (C-C motif) ligand 15 3.0363
CEACAM16 carcinoembryonic antigen-related cell adhesion molecule 16 3.0363
TBC1D28 TBC1 domain family, member 28 3.0363
FADS6 fatty acid desaturase 6 3.0363
RP1 retinitis pigmentosa 1 (autosomal dominant) 3.0363
TUBAL3 tubulin, alpha-like 3 3.0363
CHRM4 cholinergic receptor, muscarinic 4 3.0363
NXF3 nuclear RNA export factor 3 3.0363
PADI1 peptidyl arginine deiminase, type I 3.0363
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 3.0363
RNF224 ring finger protein 224 3.0363
XCR1 chemokine (C motif) receptor 1 3.0363
TRPM2 transient receptor potential cation channel, subfamily M, member 2 3.0363
MAGEA12 melanoma antigen family A12 3.0363
NUTM2B NUT family member 2B 3.0363
TEX36 testis expressed 36 3.0363
NRGN neurogranin (protein kinase C substrate, RC3) 3.0363
BPTF bromodomain PHD finger transcription factor 3.0363
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 3.0363
MYOZ2 myozenin 2 3.0363
SYTL4 synaptotagmin-like 4 3.0363
MAGEC3 melanoma antigen family C3 3.0363
GFRA1 GDNF family receptor alpha 1 2.9758
ITLN2 intelectin 2 2.90997
ADAM11 ADAM metallopeptidase domain 11 2.90997
FAHD1 fumarylacetoacetate hydrolase domain containing 1 2.86679
LEAP2 liver expressed antimicrobial peptide 2 2.86679
PHF11 PHD finger protein 11 2.81359
HLF hepatic leukemia factor 2.77776
PTDSS2 phosphatidylserine synthase 2 2.73355
HMGB2 high mobility group box 2 2.72496
MRPL55 mitochondrial ribosomal protein L55 2.68477
FREM1 FRAS1 related extracellular matrix 1 2.59312
WIPI2 WD repeat domain, phosphoinositide interacting 2 2.56333
PKP2 plakophilin 2 2.50428
OAZ1 ornithine decarboxylase antizyme 1 2.50428
ANKDD1A ankyrin repeat and death domain containing 1A 2.49765
OTUD5 OTU deubiquitinase 5 2.47913
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 2.43522
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 2.42538
C16ORF96 chromosome 16 open reading frame 96 2.40182
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2.4009
SFRP4 secreted frizzled-related protein 4 2.40071
NMBR neuromedin B receptor 2.35899
EVPL envoplakin 2.35334
TNS1-AS1 TNS1 antisense RNA 1 2.35334
MORN5 MORN repeat containing 5 2.35334
CFAP46 cilia and flagella associated protein 46 2.32717
TIPIN TIMELESS interacting protein 2.29518
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 2.28432
ZNF285 zinc finger protein 285 2.27279
TMEM141 transmembrane protein 141 2.26596
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 2.26529
ETNK1 ethanolamine kinase 1 2.26076
MOCOS molybdenum cofactor sulfurase 2.25461
TMEM219 transmembrane protein 219 2.23703
TRAPPC13 trafficking protein particle complex 13 2.22585
NR4A3 nuclear receptor subfamily 4, group A, member 3 2.22457
SOX30 SRY (sex determining region Y)-box 30 2.22457
ZHX1 zinc fingers and homeoboxes 1 2.22167
PAMR1 peptidase domain containing associated with muscle regeneration 1 2.21338
INSC inscuteable homolog (Drosophila) 2.19799
ATP5MG ATP synthase membrane subunit g 2.15231
STARD4 StAR-related lipid transfer (START) domain containing 4 2.14592
MVP major vault protein 2.13117
NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5 2.12354
COMTD1 catechol-O-methyltransferase domain containing 1 2.12079
RSBN1L round spermatid basic protein 1-like 2.10566
SNX10 sorting nexin 10 2.09539
BCL2 B-cell CLL/lymphoma 2 2.08294
CFAP418 cilia and flagella associated protein 418 2.08294
DMAC2 distal membrane arm assembly component 2 2.07429
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 2.05777
HPRT1 hypoxanthine phosphoribosyltransferase 1 2.05635
PRRC2A proline-rich coiled-coil 2A 2.0415
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2.03421
LOC102723564 uncharacterized LOC102723564 2.03421
CILP2 cartilage intermediate layer protein 2 2.02656
ZNF30 zinc finger protein 30 2.02187
EMC7 ER membrane protein complex subunit 7 2.00442
ZNF687 zinc finger protein 687 2.00204
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 2.00164

decreased expression

Symbol Name Standardized Value
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 -3.0363
ALK anaplastic lymphoma receptor tyrosine kinase -3.0363
CD5 CD5 molecule -3.0363
PADI4 peptidyl arginine deiminase, type IV -3.0363
GLRA1 glycine receptor, alpha 1 -3.0363
C1ORF87 chromosome 1 open reading frame 87 -3.0363
EDAR ectodysplasin A receptor -3.0363
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 -3.0363
IER5L immediate early response 5-like -3.0363
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) -3.0363
CEBPD CCAAT/enhancer binding protein (C/EBP), delta -3.0363
METTL16 methyltransferase like 16 -3.0363
CHRND cholinergic receptor, nicotinic, delta (muscle) -3.0363
CD68 CD68 molecule -3.0363
PLK4 polo-like kinase 4 -3.0363
SHCBP1L SHC SH2-domain binding protein 1-like -3.0363
ADAT3 adenosine deaminase, tRNA-specific 3 -3.0363
FSD2 fibronectin type III and SPRY domain containing 2 -3.0363
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 -3.0363
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit -3.0363
ETV7 ets variant 7 -3.0363
SPTB spectrin, beta, erythrocytic -3.0363
TMEM132E transmembrane protein 132E -3.0363
HSPB6 heat shock protein, alpha-crystallin-related, B6 -3.0363
CLDN23 claudin 23 -3.0363
IQCN IQ motif containing N -3.0363
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 -3.0363
GPRC6A G protein-coupled receptor, class C, group 6, member A -3.0363
GPR150 G protein-coupled receptor 150 -3.0363
FYB2 FYN binding protein 2 -3.0363
SFRP5 secreted frizzled-related protein 5 -3.0363
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 -3.0363
NTN5 netrin 5 -3.0363
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) -3.0363
FOS FBJ murine osteosarcoma viral oncogene homolog -3.0363
TMEM255A transmembrane protein 255A -3.0363
EDN1 endothelin 1 -3.0363
LTF lactotransferrin -3.0363
SYT15 synaptotagmin XV -3.0363
XKR5 XK, Kell blood group complex subunit-related family, member 5 -3.0363
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 -3.0363
LOC124904542 uncharacterized LOC124904542 -3.0363
NIBAN3 niban apoptosis regulator 3 -3.0363
MPIG6B megakaryocyte and platelet inhibitory receptor G6b -3.0363
CXCL13 chemokine (C-X-C motif) ligand 13 -3.0363
PLD6 phospholipase D family, member 6 -3.0363
RBAK RB-associated KRAB zinc finger -3.014
SLC38A4 solute carrier family 38, member 4 -3.00378
HYKK hydroxylysine kinase -2.91033
CCDC62 coiled-coil domain containing 62 -2.90997
ZFYVE27 zinc finger, FYVE domain containing 27 -2.85161
PGBD2 piggyBac transposable element derived 2 -2.80925
STK32C serine/threonine kinase 32C -2.7981
PRMT7 protein arginine methyltransferase 7 -2.79278
KITLG KIT ligand -2.53215
RBBP7 retinoblastoma binding protein 7 -2.50084
CUTA cutA divalent cation tolerance homolog (E. coli) -2.44989
PDGFD platelet derived growth factor D -2.43029
MRPL28 mitochondrial ribosomal protein L28 -2.41858
TMEM245 transmembrane protein 245 -2.41166
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 -2.40914
ZNF582 zinc finger protein 582 -2.40914
TMEM167B transmembrane protein 167B -2.40914
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 -2.40914
TADA2A transcriptional adaptor 2A -2.40914
RBBP6 retinoblastoma binding protein 6 -2.35935
BARX1 BARX homeobox 1 -2.35935
BTBD6 BTB (POZ) domain containing 6 -2.35935
CRHR2 corticotropin releasing hormone receptor 2 -2.35935
CNGB3 cyclic nucleotide gated channel beta 3 -2.35935
LCOR ligand dependent nuclear receptor corepressor -2.35899
BNIPL BCL2/adenovirus E1B 19kD interacting protein like -2.34034
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -2.32717
DCAF6 DDB1 and CUL4 associated factor 6 -2.32303
FGFR3 fibroblast growth factor receptor 3 -2.28966
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 -2.2827
FHL2 four and a half LIM domains 2 -2.28057
SAP25 Sin3A-associated protein, 25kDa -2.26808
ARMH1 armadillo like helical domain containing 1 -2.25461
DIPK1B divergent protein kinase domain 1B -2.23703
ATG16L2 autophagy related 16-like 2 (S. cerevisiae) -2.22585
UPB1 ureidopropionase, beta -2.16686
XKRX XK, Kell blood group complex subunit-related, X-linked -2.16686
TLR5 toll-like receptor 5 -2.16686
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 -2.16686
MROH8 maestro heat-like repeat family member 8 -2.16686
ETAA1 Ewing tumor-associated antigen 1 -2.15937
PPP1R3B protein phosphatase 1, regulatory subunit 3B -2.1454
PBX3 pre-B-cell leukemia homeobox 3 -2.14138
SRPRA SRP receptor subunit alpha -2.13637
CMC4 C-x(9)-C motif containing 4 -2.12354
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) -2.11646
RNF25 ring finger protein 25 -2.11366
FBLIM1 filamin binding LIM protein 1 -2.10472
C6ORF47 chromosome 6 open reading frame 47 -2.09818
DNAJC30 DnaJ (Hsp40) homolog, subfamily C, member 30 -2.09263
KIAA0825 KIAA0825 -2.08895
LNPEP leucyl/cystinyl aminopeptidase -2.08294
DLD dihydrolipoamide dehydrogenase -2.08294
TPRG1L tumor protein p63 regulated 1-like -2.07684
ZNF93 zinc finger protein 93 -2.06404
TRIOBP TRIO and F-actin binding protein -2.05878
GK glycerol kinase -2.05777
FAM149B1 family with sequence similarity 149, member B1 -2.04388
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -2.0415
TBC1D30 TBC1 domain family, member 30 -2.03421
TGFB1I1 transforming growth factor beta 1 induced transcript 1 -2.03421
KHNYN KH and NYN domain containing -2.02918
GAS7 growth arrest-specific 7 -2.02656
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) -2.01515
ARHGAP26 Rho GTPase activating protein 26 -2.01209
TEK TEK tyrosine kinase, endothelial -2.00164