PSENEN Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description presenilin enhancer gamma secretase subunit|Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] (NCBI Entrez Gene Database, 55851)
External Link http://www.ncbi.nlm.nih.gov/gene/55851
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48 interacting proteins for PSENEN from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APH1A APH1A gamma secretase subunit
APH1B APH1B gamma secretase subunit
APP amyloid beta (A4) precursor protein
CD44 CD44 molecule (Indian blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CREB3 cAMP responsive element binding protein 3
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DLL1 delta-like 1 (Drosophila)
DTX1 deltex 1, E3 ubiquitin ligase
DTX2 deltex 2, E3 ubiquitin ligase
DTX4 deltex 4, E3 ubiquitin ligase
EPHB1 EPH receptor B1
EPHB2 EPH receptor B2
EPHB3 EPH receptor B3
EPHB4 EPH receptor B4
EPHB6 EPH receptor B6
ERBB4 erb-b2 receptor tyrosine kinase 4
ERLIN2 ER lipid raft associated 2
FTL ferritin, light polypeptide
HNF4A hepatocyte nuclear factor 4, alpha
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
LRP1 low density lipoprotein receptor-related protein 1
LRP1B low density lipoprotein receptor-related protein 1B
LRP2 low density lipoprotein receptor-related protein 2
LRP3 low density lipoprotein receptor-related protein 3
LRP4 low density lipoprotein receptor-related protein 4
LRP5 low density lipoprotein receptor-related protein 5
LRP6 low density lipoprotein receptor-related protein 6
NCSTN nicastrin
NGF nerve growth factor (beta polypeptide)
NGFR nerve growth factor receptor
NOTCH1 notch 1
NOTCH2 notch 2
NOTCH3 notch 3
NOTCH4 notch 4
NRF1 nuclear respiratory factor 1
PSEN1 presenilin 1
PSEN2 presenilin 2
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C)
SDC3 syndecan 3
SORT1 sortilin 1
THBD thrombomodulin
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMED2 transmembrane emp24 domain trafficking protein 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
ZNF274 zinc finger protein 274