PSMC1 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description proteasome (prosome, macropain) 26S subunit, ATPase, 1|The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5700)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/MORF_PSMC1
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Genes

190 co-expressed genes for PSMC1 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ADAR adenosine deaminase, RNA-specific
ADRM1 adhesion regulating molecule 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
AP2M1 adaptor-related protein complex 2, mu 1 subunit
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
ARF3 ADP-ribosylation factor 3
ARF5 ADP-ribosylation factor 5
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
ATOX1 antioxidant 1 copper chaperone
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
BAG5 BCL2-associated athanogene 5
BANF1 barrier to autointegration factor 1
BCAP31 B-cell receptor-associated protein 31
BUD31 BUD31 homolog (S. cerevisiae)
C21ORF33 chromosome 21 open reading frame 33
C9ORF16 chromosome 9 open reading frame 16
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CANX calnexin
CAPNS1 calpain, small subunit 1
CBX3 chromobox homolog 3
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT7 chaperonin containing TCP1, subunit 7 (eta)
CDC123 cell division cycle 123
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDK7 cyclin-dependent kinase 7
CFDP1 craniofacial development protein 1
CLTA clathrin, light chain A
CNBP CCHC-type zinc finger, nucleic acid binding protein
CNIH1 cornichon family AMPA receptor auxiliary protein 1
COIL coilin
COMMD4 COMM domain containing 4
COPS5 COP9 signalosome subunit 5
COX11 COX11 cytochrome c oxidase copper chaperone
COX17 COX17 cytochrome c oxidase copper chaperone
COX4I1 cytochrome c oxidase subunit IV isoform 1
COX5A cytochrome c oxidase subunit Va
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver)
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like
CTCF CCCTC-binding factor (zinc finger protein)
CYC1 cytochrome c-1
DCTN2 dynactin 2 (p50)
DNPEP aspartyl aminopeptidase
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
DRG1 developmentally regulated GTP binding protein 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EIF3B eukaryotic translation initiation factor 3, subunit B
EIF3C eukaryotic translation initiation factor 3, subunit C
EIF4E2 eukaryotic translation initiation factor 4E family member 2
EIF5 eukaryotic translation initiation factor 5
ENSA endosulfine alpha
ERH enhancer of rudimentary homolog (Drosophila)
ETFA electron-transfer-flavoprotein, alpha polypeptide
FAM20B family with sequence similarity 20, member B
FUBP1 far upstream element (FUSE) binding protein 1
GABARAPL2 GABA(A) receptor-associated protein-like 2
GGCT gamma-glutamylcyclotransferase
GMFB glia maturation factor, beta
HARS2 histidyl-tRNA synthetase 2, mitochondrial
HMGN1 high mobility group nucleosome binding domain 1
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1
HSBP1 heat shock factor binding protein 1
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IST1 increased sodium tolerance 1 homolog (yeast)
JTB jumping translocation breakpoint
KARS lysyl-tRNA synthetase
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAD2L1BP MAD2L1 binding protein
MAEA macrophage erythroblast attacher
MBD4 methyl-CpG binding domain protein 4
MBTPS1 membrane-bound transcription factor peptidase, site 1
MORF4L2 mortality factor 4 like 2
MRPL9 mitochondrial ribosomal protein L9
MRPS11 mitochondrial ribosomal protein S11
MTDH metadherin
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYL12B myosin, light chain 12B, regulatory
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NME2 NME/NM23 nucleoside diphosphate kinase 2
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
PDCD6 programmed cell death 6
PITRM1 pitrilysin metallopeptidase 1
POLR2G polymerase (RNA) II (DNA directed) polypeptide G
POLR2H polymerase (RNA) II (DNA directed) polypeptide H
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1R7 protein phosphatase 1, regulatory subunit 7
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4
PPP4C protein phosphatase 4, catalytic subunit
PPP6C protein phosphatase 6, catalytic subunit
PRMT1 protein arginine methyltransferase 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PUF60 poly-U binding splicing factor 60KDa
RAB5A RAB5A, member RAS oncogene family
RAD21 RAD21 homolog (S. pombe)
RAD23B RAD23 homolog B (S. cerevisiae)
RAE1 ribonucleic acid export 1
RAN RAN, member RAS oncogene family
RBM4 RNA binding motif protein 4
RBM42 RNA binding motif protein 42
RER1 retention in endoplasmic reticulum sorting receptor 1
RNF6 ring finger protein (C3H2C3 type) 6
RPL36AL ribosomal protein L36a-like
RPP38 ribonuclease P/MRP 38kDa subunit
SAP18 Sin3A-associated protein, 18kDa
SEC13 SEC13 homolog (S. cerevisiae)
SEPHS2 selenophosphate synthetase 2
SEPT2 septin 2
SETD3 SET domain containing 3
SF3B2 splicing factor 3b, subunit 2, 145kDa
SHFM1 split hand/foot malformation (ectrodactyly) type 1
SIVA1 SIVA1, apoptosis-inducing factor
SKP1 S-phase kinase-associated protein 1
SLC7A5P1 solute carrier family 7 (amino acid transporter light chain, L system), member 5 pseudogene 1
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SMG7 SMG7 nonsense mediated mRNA decay factor
SNRPE small nuclear ribonucleoprotein polypeptide E
SNRPG small nuclear ribonucleoprotein polypeptide G
SOD1 superoxide dismutase 1, soluble
SPTLC1 serine palmitoyltransferase, long chain base subunit 1
SRP19 signal recognition particle 19kDa
SRP9 signal recognition particle 9kDa
SSNA1 Sjogren syndrome nuclear autoantigen 1
SSR2 signal sequence receptor, beta (translocon-associated protein beta)
STOML2 stomatin (EPB72)-like 2
STX16 syntaxin 16
SUMO1 small ubiquitin-like modifier 1
SUMO3 small ubiquitin-like modifier 3
SYPL1 synaptophysin-like 1
TBCA tubulin folding cofactor A
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TDG thymine-DNA glycosylase
TECR trans-2,3-enoyl-CoA reductase
TM9SF1 transmembrane 9 superfamily member 1
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM147 transmembrane protein 147
TMEM183A transmembrane protein 183A
TOP1P2 topoisomerase (DNA) I pseudogene 2
TUG1 taurine up-regulated 1 (non-protein coding)
UBA1 ubiquitin-like modifier activating enzyme 1
UBE4A ubiquitination factor E4A
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UQCRB ubiquinol-cytochrome c reductase binding protein
URI1 URI1, prefoldin-like chaperone
URM1 ubiquitin related modifier 1
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
VCP valosin containing protein
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae)
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
VTI1B vesicle transport through interaction with t-SNAREs 1B
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YY1 YY1 transcription factor
ZC3H14 zinc finger CCCH-type containing 14