PSMC2 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description proteasome (prosome, macropain) 26S subunit, ATPase, 2|The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2011] (NCBI Entrez Gene Database, 5701)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/MORF_PSMC2
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Genes

117 co-expressed genes for PSMC2 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ADAR adenosine deaminase, RNA-specific
ARCN1 archain 1
ARF5 ADP-ribosylation factor 5
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
BAG5 BCL2-associated athanogene 5
BANF1 barrier to autointegration factor 1
BCAP31 B-cell receptor-associated protein 31
BUD31 BUD31 homolog (S. cerevisiae)
BZW1 basic leucine zipper and W2 domains 1
C6ORF62 chromosome 6 open reading frame 62
CANX calnexin
CFDP1 craniofacial development protein 1
CLN3 ceroid-lipofuscinosis, neuronal 3
CNBP CCHC-type zinc finger, nucleic acid binding protein
CNIH1 cornichon family AMPA receptor auxiliary protein 1
COIL coilin
COPB1 coatomer protein complex, subunit beta 1
COPB2 coatomer protein complex, subunit beta 2 (beta prime)
COPS5 COP9 signalosome subunit 5
COX4I1 cytochrome c oxidase subunit IV isoform 1
COX5A cytochrome c oxidase subunit Va
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like
DLD dihydrolipoamide dehydrogenase
DNPEP aspartyl aminopeptidase
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
DRG1 developmentally regulated GTP binding protein 1
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
EBAG9 estrogen receptor binding site associated, antigen, 9
EIF4H eukaryotic translation initiation factor 4H
EIF5 eukaryotic translation initiation factor 5
ENSA endosulfine alpha
ETFA electron-transfer-flavoprotein, alpha polypeptide
FAM120A family with sequence similarity 120A
FAM20B family with sequence similarity 20, member B
FUBP1 far upstream element (FUSE) binding protein 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GLG1 golgi glycoprotein 1
GMFB glia maturation factor, beta
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
HARS2 histidyl-tRNA synthetase 2, mitochondrial
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HSBP1 heat shock factor binding protein 1
HTATSF1 HIV-1 Tat specific factor 1
IK IK cytokine, down-regulator of HLA II
IST1 increased sodium tolerance 1 homolog (yeast)
KARS lysyl-tRNA synthetase
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIF2A kinesin heavy chain member 2A
MBD4 methyl-CpG binding domain protein 4
METAP1 methionyl aminopeptidase 1
MORF4L2 mortality factor 4 like 2
MTDH metadherin
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYL12B myosin, light chain 12B, regulatory
NCBP2 nuclear cap binding protein subunit 2, 20kDa
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
PDCD6 programmed cell death 6
PEX11B peroxisomal biogenesis factor 11 beta
PGRMC1 progesterone receptor membrane component 1
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PITPNB phosphatidylinositol transfer protein, beta
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD)
PPP1R7 protein phosphatase 1, regulatory subunit 7
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRMT1 protein arginine methyltransferase 1
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PUF60 poly-U binding splicing factor 60KDa
RAB11A RAB11A, member RAS oncogene family
RAB1A RAB1A, member RAS oncogene family
RAB5A RAB5A, member RAS oncogene family
RAB9A RAB9A, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD21 RAD21 homolog (S. pombe)
RAD23B RAD23 homolog B (S. cerevisiae)
RAE1 ribonucleic acid export 1
RER1 retention in endoplasmic reticulum sorting receptor 1
RNF6 ring finger protein (C3H2C3 type) 6
RPL36AL ribosomal protein L36a-like
RPP38 ribonuclease P/MRP 38kDa subunit
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SEC13 SEC13 homolog (S. cerevisiae)
SEC61B Sec61 beta subunit
SEC61G Sec61 gamma subunit
SHFM1 split hand/foot malformation (ectrodactyly) type 1
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SKP1 S-phase kinase-associated protein 1
SMG7 SMG7 nonsense mediated mRNA decay factor
SP3 Sp3 transcription factor
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae)
SRP19 signal recognition particle 19kDa
SRP9 signal recognition particle 9kDa
STX4 syntaxin 4
SUMO1 small ubiquitin-like modifier 1
SYPL1 synaptophysin-like 1
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1
TMED2 transmembrane emp24 domain trafficking protein 2
TOP1P2 topoisomerase (DNA) I pseudogene 2
TUG1 taurine up-regulated 1 (non-protein coding)
UBA1 ubiquitin-like modifier activating enzyme 1
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UBXN4 UBX domain protein 4
URI1 URI1, prefoldin-like chaperone
URM1 ubiquitin related modifier 1
VCP valosin containing protein
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZNF410 zinc finger protein 410
ZZZ3 zinc finger, ZZ-type containing 3