PSME1 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)|The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] (NCBI Entrez Gene Database, 5720)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GCM_PSME1
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Genes

85 co-expressed genes for PSME1 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ACTG1 actin gamma 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APRT adenine phosphoribosyltransferase
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
ATP5F1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
BRD8 bromodomain containing 8
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1
CBFB core-binding factor, beta subunit
CFL1 cofilin 1 (non-muscle)
CLIC1 chloride intracellular channel 1
COPS5 COP9 signalosome subunit 5
CSNK2B casein kinase 2, beta polypeptide
DUT deoxyuridine triphosphatase
EEF1B2 eukaryotic translation elongation factor 1 beta 2
EIF3F eukaryotic translation initiation factor 3, subunit F
H2AFZ H2A histone family, member Z
HDAC1 histone deacetylase 1
HMGN1 high mobility group nucleosome binding domain 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPM heterogeneous nuclear ribonucleoprotein M
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HPRT1 hypoxanthine phosphoribosyltransferase 1
IK IK cytokine, down-regulator of HLA II
ILF2 interleukin enhancer binding factor 2
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
MSN moesin
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
NACA nascent polypeptide-associated complex alpha subunit
NAP1L1 nucleosome assembly protein 1-like 1
NASP nuclear autoantigenic sperm protein (histone-binding)
NCL nucleolin
NDUFA12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PCBP1 poly(rC) binding protein 1
PFN1 profilin 1
PNN pinin, desmosome associated protein
POLG polymerase (DNA directed), gamma
POLR2G polymerase (RNA) II (DNA directed) polypeptide G
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PPIA peptidylprolyl isomerase A (cyclophilin A)
PRMT1 protein arginine methyltransferase 1
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PTMA prothymosin, alpha
QARS glutaminyl-tRNA synthetase
RABGGTB Rab geranylgeranyltransferase, beta subunit
RHOA ras homolog family member A
RPL10A ribosomal protein L10a
RPL11 ribosomal protein L11
RPL17 ribosomal protein L17
RPL19 ribosomal protein L19
RPL21 ribosomal protein L21
RPL27 ribosomal protein L27
RPL35A ribosomal protein L35a
RPL6 ribosomal protein L6
RPL7 ribosomal protein L7
RPS19 ribosomal protein S19
RPS24 ribosomal protein S24
RPS5 ribosomal protein S5
RPS7 ribosomal protein S7
RPS8 ribosomal protein S8
SAP18 Sin3A-associated protein, 18kDa
SET SET nuclear proto-oncogene
SLBP stem-loop binding protein
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa
SNRPF small nuclear ribonucleoprotein polypeptide F
SRSF2 serine/arginine-rich splicing factor 2
SRSF9 serine/arginine-rich splicing factor 9
SUMO2 small ubiquitin-like modifier 2
TCEA1 transcription elongation factor A (SII), 1
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1
TMSB10 thymosin beta 10
TRA2B transformer 2 beta homolog (Drosophila)
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZNHIT3 zinc finger, HIT-type containing 3