PTEN Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description phosphatase and tensin homolog|This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015] (NCBI Entrez Gene Database, 5728)
Similar Terms
Downloads & Tools

Genes

340 genes differentially expressed following the PTEN gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
C8ORF89 chromosome 8 open reading frame 89 2.79395
OR51L1 olfactory receptor, family 51, subfamily L, member 1 2.79395
CARD18 caspase recruitment domain family, member 18 2.79395
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.79395
TAGAP T-cell activation RhoGTPase activating protein 2.79395
LONRF3 LON peptidase N-terminal domain and ring finger 3 2.79395
COL19A1 collagen, type XIX, alpha 1 2.79395
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 2.79395
STRA8 stimulated by retinoic acid 8 2.79395
ANKRD55 ankyrin repeat domain 55 2.79395
PRG4 proteoglycan 4 2.79395
BMP3 bone morphogenetic protein 3 2.79395
GYPB glycophorin B (MNS blood group) 2.79395
HAMP hepcidin antimicrobial peptide 2.79395
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 2.79395
C17ORF113 chromosome 17 open reading frame 113 2.79395
ADAM20 ADAM metallopeptidase domain 20 2.79395
H1-3 H1.3 linker histone, cluster member 2.79395
H3C3 H3 clustered histone 3 2.79395
RIMBP2 RIMS binding protein 2 2.79395
SCN10A sodium channel, voltage gated, type X alpha subunit 2.79395
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 2.77463
SCNN1G sodium channel, non voltage gated 1 gamma subunit 2.77463
KRT20 keratin 20, type I 2.77463
RWDD1 RWD domain containing 1 2.77463
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 2.77463
GJB3 gap junction protein, beta 3, 31kDa 2.77463
MUC5B mucin 5B, oligomeric mucus/gel-forming 2.77463
MBD3L3 methyl-CpG binding domain protein 3-like 3 2.77463
ESX1 ESX homeobox 1 2.77463
CEP295NL CEP295 N-terminal like 2.77463
MYOM2 myomesin 2 2.77463
TBATA thymus, brain and testes associated 2.77463
C3ORF22 chromosome 3 open reading frame 22 2.77463
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 2.77463
NLRP8 NLR family, pyrin domain containing 8 2.77463
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 2.77463
BOLA2 bolA family member 2 2.77463
XAGE3 X antigen family, member 3 2.77463
C5ORF46 chromosome 5 open reading frame 46 2.77463
FAM9C family with sequence similarity 9, member C 2.77463
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.77463
AIRE autoimmune regulator 2.77463
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 2.77463
BFSP2 beaded filament structural protein 2, phakinin 2.77463
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 2.77463
TREML1 triggering receptor expressed on myeloid cells-like 1 2.77463
HBM hemoglobin, mu 2.77463
LGI1 leucine-rich, glioma inactivated 1 2.77463
SPDYE11 speedy/RINGO cell cycle regulator family member E11 2.77463
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 2.77463
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 2.77463
SPATA31G1 SPATA31 subfamily G member 1 2.77463
ROPN1L rhophilin associated tail protein 1-like 2.77463
TRPC7 transient receptor potential cation channel, subfamily C, member 7 2.77463
LOC124905976 uncharacterized LOC124905976 2.77463
C20ORF202 chromosome 20 open reading frame 202 2.77463
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 2.77463
GMCL2 germ cell-less 2, spermatogenesis associated 2.77463
FOXC1 forkhead box C1 2.77463
OR52E2 olfactory receptor, family 52, subfamily E, member 2 2.77463
ALDOB aldolase B, fructose-bisphosphate 2.77463
SEPTIN14 septin 14 2.77463
SPMIP7 sperm microtubule inner protein 7 2.77463
TBC1D3I TBC1 domain family member 3I 2.77463
H3C13 H3 clustered histone 13 2.77463
H4C15 H4 clustered histone 15 2.77463
ARMH2 armadillo like helical domain containing 2 2.77463
MEIOSIN meiosis initiator 2.77463
NFILZ NFIL3 like basic leucine zipper 2.77463
ANGPTL8 angiopoietin like 8 2.77463
LY6H lymphocyte antigen 6 complex, locus H 2.77463
CSAG2 CSAG family, member 2 2.77463
SOAT2 sterol O-acyltransferase 2 2.77463
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.77463
SRPX2 sushi-repeat containing protein, X-linked 2 2.77463
ZACN zinc activated ligand-gated ion channel 2.77463
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 2.77463
IL5 interleukin 5 2.77463
IGFL3 IGF-like family member 3 2.77463
NANOS3 nanos homolog 3 (Drosophila) 2.77463
MAGEA2 melanoma antigen family A2 2.77463
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 2.77463
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 2.77463
GDF7 growth differentiation factor 7 2.77463
UTS2 urotensin 2 2.77463
CLDN22 claudin 22 2.77463
CREB3L3 cAMP responsive element binding protein 3-like 3 2.77463
TLR9 toll-like receptor 9 2.77463
TLR1 toll-like receptor 1 2.77463
TMCO2 transmembrane and coiled-coil domains 2 2.77463
GOLGA6L2 golgin A6 family-like 2 2.77463
ZNF467 zinc finger protein 467 2.77463
UPK1A uroplakin 1A 2.77463
ODF4 outer dense fiber of sperm tails 4 2.77463
MAB21L2 mab-21-like 2 (C. elegans) 2.77463
APOC4 apolipoprotein C-IV 2.77463
HAVCR1 hepatitis A virus cellular receptor 1 2.77463
EMX2 empty spiracles homeobox 2 2.77463
NOX1 NADPH oxidase 1 2.77463
HSPA1L heat shock 70kDa protein 1-like 2.77463
OR9A4 olfactory receptor, family 9, subfamily A, member 4 2.77463
EBLN1 endogenous Bornavirus-like nucleoprotein 1 2.77463
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 2.77463
CT55 cancer/testis antigen 55 2.77463
DPT dermatopontin 2.77463
ZSCAN4 zinc finger and SCAN domain containing 4 2.77463
AKR1B15 aldo-keto reductase family 1, member B15 2.77463
ZNF132 zinc finger protein 132 2.77463
NACA2 nascent polypeptide-associated complex alpha subunit 2 2.77463
VAX2 ventral anterior homeobox 2 2.77463
FOXE3 forkhead box E3 2.77463
WNT7A wingless-type MMTV integration site family, member 7A 2.77463
OR52N5 olfactory receptor, family 52, subfamily N, member 5 2.77463
WNT1 wingless-type MMTV integration site family, member 1 2.77463
CNR2 cannabinoid receptor 2 (macrophage) 2.77463
POU4F1 POU class 4 homeobox 1 2.77463
DCT dopachrome tautomerase 2.77463
GPR61 G protein-coupled receptor 61 2.77463
PRSS38 protease, serine, 38 2.77463
VAV1 vav 1 guanine nucleotide exchange factor 2.77463
ZC3H12D zinc finger CCCH-type containing 12D 2.77463
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.77463
IL9R interleukin 9 receptor 2.77463
MUC7 mucin 7, secreted 2.77463
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 2.77463
PATE4 prostate and testis expressed 4 2.77463
ZCCHC12 zinc finger, CCHC domain containing 12 2.77463
COMP cartilage oligomeric matrix protein 2.77463
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 2.77463
SPAG11B sperm associated antigen 11B 2.77463
CLK3 CDC-like kinase 3 2.77463
AMER3 APC membrane recruitment protein 3 2.77463
CETP cholesteryl ester transfer protein, plasma 2.77463
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 2.77463
NNMT nicotinamide N-methyltransferase 2.77463
CHRM4 cholinergic receptor, muscarinic 4 2.77463
SYTL4 synaptotagmin-like 4 2.77463
TMEM215 transmembrane protein 215 2.77463
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 2.77463
PAGE2B P antigen family, member 2B 2.77463
OR52I2 olfactory receptor, family 52, subfamily I, member 2 2.77463
AQP1 aquaporin 1 (Colton blood group) 2.77463
APOL5 apolipoprotein L, 5 2.77463
TGM7 transglutaminase 7 2.77463
VCAM1 vascular cell adhesion molecule 1 2.77463
BPIFC BPI fold containing family C 2.77463
ERVV-1 endogenous retrovirus group V, member 1 2.77463
HOXD13 homeobox D13 2.77463
TUBAL3 tubulin, alpha-like 3 2.77463
RHAG Rh-associated glycoprotein 2.77463
CARD9 caspase recruitment domain family, member 9 2.77463
EPRS1 glutamyl-prolyl-tRNA synthetase 1 2.73471
INSC inscuteable homolog (Drosophila) 2.71398
EIF3E eukaryotic translation initiation factor 3, subunit E 2.66056
TACC3 transforming, acidic coiled-coil containing protein 3 2.63731
OSBPL9 oxysterol binding protein-like 9 2.59417
VBP1 von Hippel-Lindau binding protein 1 2.57925
CWC15 CWC15 spliceosome-associated protein 2.54308
ZBED8 zinc finger, BED-type containing 8 2.49239
MACF1 microtubule-actin crosslinking factor 1 2.47684
ADD3 adducin 3 (gamma) 2.47433
CYB5D1 cytochrome b5 domain containing 1 2.4715
TRIM11 tripartite motif containing 11 2.45144
TPTE transmembrane phosphatase with tensin homology 2.45135
LMX1B LIM homeobox transcription factor 1, beta 2.45135
C2ORF72 chromosome 2 open reading frame 72 2.44965
TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 2.42313
PNPLA7 patatin-like phospholipase domain containing 7 2.37172
ZNF624 zinc finger protein 624 2.36678
RASL10A RAS-like, family 10, member A 2.3605
FGFBP3 fibroblast growth factor binding protein 3 2.35597
GSKIP GSK3B interacting protein 2.29499
PKD1 polycystic kidney disease 1 (autosomal dominant) 2.28531
TMEM275 transmembrane protein 275 2.28383
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.25442
MARVELD1 MARVEL domain containing 1 2.25045
ERMAP erythroblast membrane-associated protein (Scianna blood group) 2.24494
TTC39A tetratricopeptide repeat domain 39A 2.24394
EBNA1BP2 EBNA1 binding protein 2 2.23268
HARS2 histidyl-tRNA synthetase 2, mitochondrial 2.22694
LYN LYN proto-oncogene, Src family tyrosine kinase 2.22458
RUSC2 RUN and SH3 domain containing 2 2.21679
PIGX phosphatidylinositol glycan anchor biosynthesis, class X 2.20967
SF3B6 splicing factor 3b, subunit 6, 14kDa 2.209
CPN1 carboxypeptidase N, polypeptide 1 2.209
TIMCC TIM double twin CX3C motif chaperone 2.20794
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) 2.20794
DUT deoxyuridine triphosphatase 2.18038
RBM7 RNA binding motif protein 7 2.17906
TIGAR TP53 induced glycolysis regulatory phosphatase 2.17295
STAMBPL1 STAM binding protein-like 1 2.16513
IGFLR1 IGF-like family receptor 1 2.15997
ZNF718 zinc finger protein 718 2.1424
RUFY2 RUN and FYVE domain containing 2 2.14016
CDKL5 cyclin-dependent kinase-like 5 2.13728
FSTL4 follistatin-like 4 2.13483
ZMAT3 zinc finger, matrin-type 3 2.13483
PHACTR1 phosphatase and actin regulator 1 2.13483
ANKRD30BL ankyrin repeat domain 30B-like 2.12479
TICAM2 toll-like receptor adaptor molecule 2 2.12274
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 2.11305
CPEB2 cytoplasmic polyadenylation element binding protein 2 2.11305
CCDC92B coiled-coil domain containing 92B 2.11305
SESN2 sestrin 2 2.09972
PITPNA phosphatidylinositol transfer protein, alpha 2.08626
PLAGL2 pleiomorphic adenoma gene-like 2 2.08429
RNF152 ring finger protein 152 2.08429
STARD13 StAR-related lipid transfer (START) domain containing 13 2.0801
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 2.06366
INKA1 inka box actin regulator 1 2.0611
TRAPPC12 trafficking protein particle complex 12 2.04522
PWWP3B PWWP domain containing 3B 2.04522
ZNF189 zinc finger protein 189 2.02957
IFT81 intraflagellar transport 81 2.02957
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.02957
PYROXD2 pyridine nucleotide-disulphide oxidoreductase domain 2 2.02957
GDPGP1 GDP-D-glucose phosphorylase 1 2.02087
IREB2 iron-responsive element binding protein 2 2.02087
EBAG9 estrogen receptor binding site associated, antigen, 9 2.02062
CXORF38 chromosome X open reading frame 38 2.02062
ARRDC4 arrestin domain containing 4 2.0165

decreased expression

Symbol Name Standardized Value
PVALEF parvalbumin like EF-hand containing -2.79395
KLK4 kallikrein-related peptidase 4 -2.79395
CSNK2A3 casein kinase 2, alpha 3 polypeptide -2.79395
PRRX1 paired related homeobox 1 -2.77463
SENP5 SUMO1/sentrin specific peptidase 5 -2.77463
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 -2.77463
PHOSPHO1 phosphatase, orphan 1 -2.77463
OR6A2 olfactory receptor, family 6, subfamily A, member 2 -2.77463
ACVRL1 activin A receptor type II-like 1 -2.77463
MAPK11 mitogen-activated protein kinase 11 -2.77463
ELL2 elongation factor, RNA polymerase II, 2 -2.77463
LIN54 lin-54 DREAM MuvB core complex component -2.77463
PGM5 phosphoglucomutase 5 -2.77463
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 -2.77463
OR2AG2 olfactory receptor, family 2, subfamily AG, member 2 -2.77463
MCM9 minichromosome maintenance complex component 9 -2.77463
MARCHF10 membrane associated ring-CH-type finger 10 -2.77463
PRORP protein only RNase P catalytic subunit -2.77463
TBC1D3L TBC1 domain family, member 3L -2.77463
NDP Norrie disease (pseudoglioma) -2.77463
OVOL1 ovo-like zinc finger 1 -2.77463
SPDYC speedy/RINGO cell cycle regulator family member C -2.77463
BEND7 BEN domain containing 7 -2.77463
PTEN phosphatase and tensin homolog -2.77463
USH1G Usher syndrome 1G (autosomal recessive) -2.77463
NAPSA napsin A aspartic peptidase -2.77463
SLC46A2 solute carrier family 46, member 2 -2.77463
HEATR6 HEAT repeat containing 6 -2.77463
FNDC8 fibronectin type III domain containing 8 -2.77463
RAD54L RAD54-like (S. cerevisiae) -2.77463
GOLGA8K golgin A8 family, member K -2.77463
UTS2B urotensin 2B -2.77463
DOCK8 dedicator of cytokinesis 8 -2.77463
CLDN23 claudin 23 -2.71454
ANKRD65 ankyrin repeat domain 65 -2.71398
NIBAN3 niban apoptosis regulator 3 -2.71162
FPGT fucose-1-phosphate guanylyltransferase -2.71162
GLIPR1 GLI pathogenesis-related 1 -2.71162
RMP64 ribonuclease MRP subunit p64 -2.66872
SDR42E2 short chain dehydrogenase/reductase family 42E, member 2 -2.63675
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta -2.63387
RNF43 ring finger protein 43 -2.62997
BMERB1 bMERB domain containing 1 -2.61382
AIF1 allograft inflammatory factor 1 -2.61
ACTC1 actin, alpha, cardiac muscle 1 -2.60447
MGST1 microsomal glutathione S-transferase 1 -2.59438
C1QTNF7 C1q and tumor necrosis factor related protein 7 -2.54819
EIF3A eukaryotic translation initiation factor 3, subunit A -2.53657
KLHL42 kelch-like family member 42 -2.49597
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 -2.47684
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) -2.47684
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -2.45135
MAMLD1 mastermind-like domain containing 1 -2.45135
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 -2.45135
KISS1R KISS1 receptor -2.45135
ZBTB42 zinc finger and BTB domain containing 42 -2.45135
IRAK3 interleukin-1 receptor-associated kinase 3 -2.45135
GPAT3 glycerol-3-phosphate acyltransferase 3 -2.45135
LASP1NB LASP1 neighbor -2.39725
WIPI2 WD repeat domain, phosphoinositide interacting 2 -2.39235
FAM3C family with sequence similarity 3, member C -2.38037
LSM11 LSM11, U7 small nuclear RNA associated -2.37569
LMO3 LIM domain only 3 (rhombotin-like 2) -2.37286
NOP2 NOP2 nucleolar protein -2.37286
FBLIM1 filamin binding LIM protein 1 -2.3641
PHC1 polyhomeotic homolog 1 (Drosophila) -2.35744
STRAP serine/threonine kinase receptor associated protein -2.34619
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -2.32519
PDE7A phosphodiesterase 7A -2.31557
INMT indolethylamine N-methyltransferase -2.28531
DGKA diacylglycerol kinase, alpha 80kDa -2.28383
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 -2.27148
SOBP sine oculis binding protein homolog (Drosophila) -2.25752
NME4 NME/NM23 nucleoside diphosphate kinase 4 -2.25505
ENO1 enolase 1, (alpha) -2.24394
ERI2 ERI1 exoribonuclease family member 2 -2.24265
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12 -2.24265
PCSK7 proprotein convertase subtilisin/kexin type 7 -2.23352
GGPS1 geranylgeranyl diphosphate synthase 1 -2.23318
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 -2.22694
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 -2.22694
ZNF404 zinc finger protein 404 -2.21528
PIERCE2 piercer of microtubule wall 2 -2.19791
SAV1 salvador family WW domain containing protein 1 -2.18881
ZFP69 ZFP69 zinc finger protein -2.17418
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.16504
GJA4 gap junction protein, alpha 4, 37kDa -2.16404
LDLRAD2 low density lipoprotein receptor class A domain containing 2 -2.16404
LAMA3 laminin, alpha 3 -2.16404
PIGH phosphatidylinositol glycan anchor biosynthesis, class H -2.14781
CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2 -2.1424
TXNDC16 thioredoxin domain containing 16 -2.13483
STRA6 stimulated by retinoic acid 6 -2.12479
EFNB3 ephrin-B3 -2.12479
TMC5 transmembrane channel-like 5 -2.12274
MCTP1 multiple C2 domains, transmembrane 1 -2.12274
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 -2.11305
RBM18 RNA binding motif protein 18 -2.11305
STK25 serine/threonine kinase 25 -2.1089
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1 -2.1089
ZNF761 zinc finger protein 761 -2.1089
TOR3A torsin family 3, member A -2.09922
SCRN3 secernin 3 -2.09708
RAB40C RAB40C, member RAS oncogene family -2.09708
NDE1 nudE neurodevelopment protein 1 -2.09385
VRK2 vaccinia related kinase 2 -2.08626
FBXO30 F-box protein 30 -2.08429
CTSZ cathepsin Z -2.06019
VEZF1 vascular endothelial zinc finger 1 -2.04069
RHOC ras homolog family member C -2.03827
TMEM223 transmembrane protein 223 -2.03341
MLX MLX, MAX dimerization protein -2.03341
CLIC6 chloride intracellular channel 6 -2.02957
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -2.02957
PIMREG PICALM interacting mitotic regulator -2.02087
OSBPL5 oxysterol binding protein-like 5 -2.01573
FEZF1 FEZ family zinc finger 1 -2.01573
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2 -2.00314