| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | phosphatase and tensin homolog|This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015] (NCBI Entrez Gene Database, 5728) |
| External Link | https://ncbi.nlm.nih.gov/gene/5728 |
| Similar Terms | |
| Downloads & Tools |
499 genes differentially expressed following the PTEN gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | 0.0205473 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | 0.0164013 |
| XIC | X chromosome inactivation center | 0.015729 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0146306 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | 0.0144885 |
| CRABP2 | cellular retinoic acid binding protein 2 | 0.0123209 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 0.0119066 |
| KRT15 | keratin 15, type I | 0.0115065 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.0114041 |
| PUF60 | poly-U binding splicing factor 60KDa | 0.0111449 |
| FABP4 | fatty acid binding protein 4, adipocyte | 0.0111215 |
| MSX1 | msh homeobox 1 | 0.0108732 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.0107674 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0107598 |
| MYBPC1 | myosin binding protein C, slow type | 0.0104242 |
| GOLGA8A | golgin A8 family, member A | 0.010115 |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | 0.00994768 |
| ACTA1 | actin, alpha 1, skeletal muscle | 0.00974667 |
| MMP7 | matrix metallopeptidase 7 | 0.00960064 |
| COL15A1 | collagen, type XV, alpha 1 | 0.0094716 |
| CXCL6 | chemokine (C-X-C motif) ligand 6 | 0.00946811 |
| AQP3 | aquaporin 3 (Gill blood group) | 0.00936616 |
| SCUBE2 | signal peptide, CUB domain, EGF-like 2 | 0.00922074 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | 0.00914901 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | 0.00901892 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.00892588 |
| SYNM | synemin, intermediate filament protein | 0.00889303 |
| OXTR | oxytocin receptor | 0.00886294 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.00881962 |
| CA2 | carbonic anhydrase II | 0.00879094 |
| FHOD3 | formin homology 2 domain containing 3 | 0.00873393 |
| KRT23 | keratin 23, type I | 0.00871246 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | 0.00866515 |
| RTN2 | reticulon 2 | 0.00866321 |
| MMP3 | matrix metallopeptidase 3 | 0.00865646 |
| TFF1 | trefoil factor 1 | 0.00839853 |
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | 0.00834885 |
| GOLM1 | golgi membrane protein 1 | 0.00834395 |
| EGR3 | early growth response 3 | 0.00832374 |
| USP7 | ubiquitin specific peptidase 7 (herpes virus-associated) | 0.00831433 |
| CTSG | cathepsin G | 0.00825085 |
| KRT17 | keratin 17, type I | 0.0081882 |
| YBX3 | Y box binding protein 3 | 0.00816195 |
| FZD10 | frizzled class receptor 10 | 0.00804968 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | 0.0080117 |
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.00793714 |
| ELANE | elastase, neutrophil expressed | 0.00792467 |
| PRAME | preferentially expressed antigen in melanoma | 0.00787541 |
| MCM2 | minichromosome maintenance complex component 2 | 0.00780059 |
| LTF | lactotransferrin | 0.00778729 |
| TTN | titin | 0.00771714 |
| DES | desmin | 0.00770564 |
| NXF1 | nuclear RNA export factor 1 | 0.00764867 |
| SFRP1 | secreted frizzled-related protein 1 | 0.0076213 |
| VTCN1 | V-set domain containing T cell activation inhibitor 1 | 0.00757715 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | 0.00752133 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.00751659 |
| HSPA1A | heat shock 70kDa protein 1A | 0.00747179 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.00743187 |
| MPO | myeloperoxidase | 0.00739726 |
| LY6D | lymphocyte antigen 6 complex, locus D | 0.00734611 |
| ACTG2 | actin, gamma 2, smooth muscle, enteric | 0.00733665 |
| CALML5 | calmodulin-like 5 | 0.00729744 |
| UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) | 0.00723865 |
| SRSF6 | serine/arginine-rich splicing factor 6 | 0.00722766 |
| G0S2 | G0/G1 switch 2 | 0.00717928 |
| ALDH3B2 | aldehyde dehydrogenase 3 family, member B2 | 0.00711537 |
| TNC | tenascin C | 0.00709582 |
| RGCC | regulator of cell cycle | 0.00705106 |
| FMOD | fibromodulin | 0.00696934 |
| RNASE2 | ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) | 0.00690202 |
| TNNC2 | troponin C type 2 (fast) | 0.00689004 |
| CYTH1 | cytohesin 1 | 0.0068888 |
| JAK1 | Janus kinase 1 | 0.00683523 |
| DMD | dystrophin | 0.00682835 |
| MXI1 | MAX interactor 1, dimerization protein | 0.00677273 |
| LRP4 | low density lipoprotein receptor-related protein 4 | 0.00675268 |
| APOD | apolipoprotein D | 0.0067415 |
| OLFM1 | olfactomedin 1 | 0.00673939 |
| PIP | prolactin-induced protein | 0.00672802 |
| AHNAK | AHNAK nucleoprotein | 0.00668561 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.00667981 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.00666739 |
| ZBTB35 | zinc finger and BTB domain containing 35 | 0.00665639 |
| GLA | galactosidase, alpha | 0.00664301 |
| HOMER1 | homer scaffolding protein 1 | 0.00662061 |
| KLHL41 | kelch-like family member 41 | 0.00657692 |
| MICB | MHC class I polypeptide-related sequence B | 0.00656846 |
| NTS | neurotensin | 0.00653554 |
| CALML3 | calmodulin-like 3 | 0.00650931 |
| SLC43A3 | solute carrier family 43, member 3 | 0.00650636 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0064847 |
| DIO2 | deiodinase, iodothyronine, type II | 0.00646932 |
| CRISP3 | cysteine-rich secretory protein 3 | 0.00645056 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.00644136 |
| ACTC1 | actin, alpha, cardiac muscle 1 | 0.00644002 |
| LGALS13 | lectin, galactoside-binding, soluble, 13 | 0.00643879 |
| KYNU | kynureninase | 0.00641603 |
| ANXA3 | annexin A3 | 0.00639085 |
| IL6 | interleukin 6 | 0.00635555 |
| PDZK1IP1 | PDZK1 interacting protein 1 | 0.00635148 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.006349 |
| NGFRAP1 | nerve growth factor receptor (TNFRSF16) associated protein 1 | 0.0063254 |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | 0.00630816 |
| PSAT1 | phosphoserine aminotransferase 1 | 0.00628632 |
| HSPA4 | heat shock 70kDa protein 4 | 0.00628045 |
| AMDHD2 | amidohydrolase domain containing 2 | 0.00627905 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.00626909 |
| SLC39A6 | solute carrier family 39 (zinc transporter), member 6 | 0.0062619 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | 0.00624801 |
| HSPB8 | heat shock 22kDa protein 8 | 0.0062432 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | 0.00623576 |
| MPPED2 | metallophosphoesterase domain containing 2 | 0.00622034 |
| COL4A5 | collagen, type IV, alpha 5 | 0.00621404 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.00618197 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | 0.00617972 |
| DSG1 | desmoglein 1 | 0.00614967 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.00611541 |
| KLF4 | Kruppel-like factor 4 (gut) | 0.0061122 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.00610632 |
| OSR2 | odd-skipped related transciption factor 2 | 0.00610085 |
| VCP | valosin containing protein | 0.00608618 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.00607668 |
| RAI2 | retinoic acid induced 2 | 0.00607489 |
| FNBP4 | formin binding protein 4 | 0.00606293 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.00603032 |
| HBB | hemoglobin, beta | 0.00602116 |
| LRIG1 | leucine-rich repeats and immunoglobulin-like domains 1 | 0.00601388 |
| FNDC3B | fibronectin type III domain containing 3B | 0.00599101 |
| TBX3 | T-box 3 | 0.00595478 |
| EDN3 | endothelin 3 | 0.00595132 |
| PLAT | plasminogen activator, tissue | 0.00594932 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | 0.0059405 |
| UPF3B | UPF3 regulator of nonsense transcripts homolog B (yeast) | 0.0059397 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.00593745 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.00592956 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | 0.00592559 |
| STC1 | stanniocalcin 1 | 0.00592407 |
| GPC3 | glypican 3 | 0.00591554 |
| STC2 | stanniocalcin 2 | 0.00591519 |
| RRP12 | ribosomal RNA processing 12 homolog (S. cerevisiae) | 0.00591207 |
| FUS | FUS RNA binding protein | 0.00590201 |
| HOXC6 | homeobox C6 | 0.00587956 |
| OGN | osteoglycin | 0.00587821 |
| FKBP4 | FK506 binding protein 4, 59kDa | 0.00587715 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | 0.00587586 |
| IL27RA | interleukin 27 receptor, alpha | 0.00583926 |
| SCRIB | scribbled planar cell polarity protein | 0.00583668 |
| GOLGB1 | golgin B1 | 0.00583282 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | 0.00583138 |
| PTCH1 | patched 1 | 0.00582833 |
| LAMA2 | laminin, alpha 2 | 0.00581762 |
| SMPX | small muscle protein, X-linked | 0.00580829 |
| ELAPOR1 | endosome-lysosome associated apoptosis and autophagy regulator 1 | 0.00579384 |
| ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | 0.00578688 |
| DKK2 | dickkopf WNT signaling pathway inhibitor 2 | 0.00577572 |
| BAG3 | BCL2-associated athanogene 3 | 0.0057637 |
| TSPYL5 | TSPY-like 5 | 0.00576301 |
| NES | nestin | 0.00574986 |
| RBM39 | RNA binding motif protein 39 | 0.00574912 |
| HSPE1 | heat shock 10kDa protein 1 | 0.0057458 |
| MYL2 | myosin, light chain 2, regulatory, cardiac, slow | 0.00574486 |
| TNNI2 | troponin I type 2 (skeletal, fast) | 0.00572468 |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B | 0.00571527 |
| PKIA | protein kinase (cAMP-dependent, catalytic) inhibitor alpha | 0.00571255 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.00569416 |
| FLNA | filamin A, alpha | 0.00569305 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | 0.00568285 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | 0.00563288 |
| MYH3 | myosin, heavy chain 3, skeletal muscle, embryonic | 0.00562852 |
| HBEGF | heparin-binding EGF-like growth factor | 0.00561791 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.00561311 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.00561283 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.00557971 |
| WDR59 | WD repeat domain 59 | 0.00557766 |
| ESR1 | estrogen receptor 1 | 0.00557208 |
| HSPA4L | heat shock 70kDa protein 4-like | 0.00555152 |
| ZNF750 | zinc finger protein 750 | 0.00554986 |
| TP63 | tumor protein p63 | 0.00554816 |
| CYP26B1 | cytochrome P450, family 26, subfamily B, polypeptide 1 | 0.00553019 |
| MYOM2 | myomesin 2 | 0.00552237 |
| FAM189A2 | family with sequence similarity 189, member A2 | 0.00552083 |
| MYOT | myotilin | 0.0055203 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.00551293 |
| FABP7 | fatty acid binding protein 7, brain | 0.00550275 |
| IRS2 | insulin receptor substrate 2 | 0.00549858 |
| ATP1A1 | ATPase, Na+/K+ transporting, alpha 1 polypeptide | 0.00549372 |
| NINJ1 | ninjurin 1 | 0.00549233 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | 0.00547978 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.00547962 |
| KRT2 | keratin 2, type II | 0.0054503 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.00544103 |
| GAD1 | glutamate decarboxylase 1 (brain, 67kDa) | 0.00542892 |
| MATN2 | matrilin 2 | 0.00538986 |
| FOXE1 | forkhead box E1 | 0.00537758 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0053505 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.00535028 |
| FZD7 | frizzled class receptor 7 | 0.00534645 |
| CRYAB | crystallin, alpha B | 0.00532834 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | 0.00532066 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.00531779 |
| RPL10 | ribosomal protein L10 | 0.00531562 |
| AZU1 | azurocidin 1 | 0.00530677 |
| DLD | dihydrolipoamide dehydrogenase | 0.00528844 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 0.00528332 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0052749 |
| NOVA1 | neuro-oncological ventral antigen 1 | 0.00527282 |
| MYH2 | myosin, heavy chain 2, skeletal muscle, adult | 0.00524136 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.0052376 |
| NAV2 | neuron navigator 2 | 0.00522066 |
| FNBP1 | formin binding protein 1 | 0.00521559 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | 0.00521092 |
| TM4SF20 | transmembrane 4 L six family member 20 | 0.00520505 |
| MSL1 | male-specific lethal 1 homolog (Drosophila) | 0.00519831 |
| RYR1 | ryanodine receptor 1 (skeletal) | 0.00519166 |
| WNT4 | wingless-type MMTV integration site family, member 4 | 0.00518631 |
| KRT14 | keratin 14, type I | 0.00518164 |
| FCGBP | Fc fragment of IgG binding protein | 0.00517573 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.00517255 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.00513887 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.00513782 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.00513036 |
| EIF6 | eukaryotic translation initiation factor 6 | 0.00513017 |
| COL1A1 | collagen, type I, alpha 1 | 0.00512518 |
| THBS4 | thrombospondin 4 | 0.00511722 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.00510253 |
| PUM1 | pumilio RNA-binding family member 1 | 0.00509717 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.00509383 |
| MYO6 | myosin VI | 0.00508384 |
| NOD2 | nucleotide-binding oligomerization domain containing 2 | 0.0050767 |
| PNN | pinin, desmosome associated protein | 0.00506573 |
| IL32 | interleukin 32 | 0.00503574 |
| MXRA5 | matrix-remodelling associated 5 | 0.00503277 |
| ACADVL | acyl-CoA dehydrogenase, very long chain | 0.00500927 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.00500921 |
| NR5A1 | nuclear receptor subfamily 5, group A, member 1 | 0.00500255 |
| NBPF10 | neuroblastoma breakpoint family, member 10 | 0.00500164 |
| ORC1 | origin recognition complex, subunit 1 | 0.00499895 |
| U2AF1 | U2 small nuclear RNA auxiliary factor 1 | 0.00499833 |
| SOAT1 | sterol O-acyltransferase 1 | 0.00499564 |
| ARGLU1 | arginine and glutamate rich 1 | 0.00498449 |
| PTPN2 | protein tyrosine phosphatase, non-receptor type 2 | 0.00498293 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.00497493 |
| KIF14 | kinesin family member 14 | 0.0049625 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | 0.00495184 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | 0.00493349 |
| CKM | creatine kinase, muscle | 0.00491276 |
| S100A7 | S100 calcium binding protein A7 | 0.0049088 |
| TNNC1 | troponin C type 1 (slow) | 0.00490408 |
| EGR2 | early growth response 2 | 0.00489768 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0161366 |
| ADIRF | adipogenesis regulatory factor | -0.0125507 |
| FGFR3 | fibroblast growth factor receptor 3 | -0.0109069 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | -0.0102569 |
| KDM5D | lysine (K)-specific demethylase 5D | -0.00987813 |
| HTRA1 | HtrA serine peptidase 1 | -0.00984874 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | -0.00954691 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | -0.00954244 |
| VCAM1 | vascular cell adhesion molecule 1 | -0.00952615 |
| JCHAIN | joining chain of multimeric IgA and IgM | -0.00950533 |
| PDGFC | platelet derived growth factor C | -0.00943258 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | -0.0093294 |
| FN1 | fibronectin 1 | -0.00931205 |
| WDR7 | WD repeat domain 7 | -0.00918153 |
| RHOB | ras homolog family member B | -0.00909496 |
| SNX7 | sorting nexin 7 | -0.00895519 |
| PRDX4 | peroxiredoxin 4 | -0.00889441 |
| C1QA | complement component 1, q subcomponent, A chain | -0.00885343 |
| THBS1 | thrombospondin 1 | -0.00873969 |
| C1QB | complement component 1, q subcomponent, B chain | -0.0087194 |
| FEZ1 | fasciculation and elongation protein zeta 1 (zygin I) | -0.00859894 |
| FKBP1B | FK506 binding protein 1B, 12.6 kDa | -0.00847932 |
| GUCY1A3 | guanylate cyclase 1, soluble, alpha 3 | -0.00844645 |
| EPHX1 | epoxide hydrolase 1, microsomal (xenobiotic) | -0.00826779 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.00812723 |
| METRN | meteorin, glial cell differentiation regulator | -0.00807788 |
| TRIB2 | tribbles pseudokinase 2 | -0.00801375 |
| C10ORF10 | chromosome 10 open reading frame 10 | -0.00794908 |
| PTK2B | protein tyrosine kinase 2 beta | -0.00775155 |
| CA12 | carbonic anhydrase XII | -0.00770435 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.00767826 |
| LPAR1 | lysophosphatidic acid receptor 1 | -0.00765583 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.00761855 |
| THBS2 | thrombospondin 2 | -0.00753604 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.00742399 |
| PLS3 | plastin 3 | -0.00737421 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | -0.00736441 |
| MAP7 | microtubule-associated protein 7 | -0.0073374 |
| GALNT1 | polypeptide N-acetylgalactosaminyltransferase 1 | -0.00733434 |
| LMO3 | LIM domain only 3 (rhombotin-like 2) | -0.0072361 |
| HMGB3 | high mobility group box 3 | -0.00721009 |
| TPSAB1 | tryptase alpha/beta 1 | -0.00720323 |
| GNG10 | guanine nucleotide binding protein (G protein), gamma 10 | -0.00719816 |
| SAMSN1 | SAM domain, SH3 domain and nuclear localization signals 1 | -0.00718342 |
| NCDN | neurochondrin | -0.00711678 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.00711333 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | -0.00710097 |
| METTL7A | methyltransferase like 7A | -0.00706464 |
| FUCA1 | fucosidase, alpha-L- 1, tissue | -0.00705442 |
| SLC14A1 | solute carrier family 14 (urea transporter), member 1 (Kidd blood group) | -0.00704531 |
| CD163 | CD163 molecule | -0.00703921 |
| EVI2A | ecotropic viral integration site 2A | -0.00699309 |
| RGS4 | regulator of G-protein signaling 4 | -0.00699223 |
| CREBL2 | cAMP responsive element binding protein-like 2 | -0.00695112 |
| RGS1 | regulator of G-protein signaling 1 | -0.006935 |
| AOC1 | amine oxidase, copper containing 1 | -0.00691179 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | -0.00684383 |
| DYNLL1 | dynein, light chain, LC8-type 1 | -0.00674697 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.00674585 |
| PTGDS | prostaglandin D2 synthase 21kDa (brain) | -0.00673618 |
| UQCR11 | ubiquinol-cytochrome c reductase, complex III subunit XI | -0.00670359 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -0.00670174 |
| ZNF652 | zinc finger protein 652 | -0.00668117 |
| MS4A4A | membrane-spanning 4-domains, subfamily A, member 4A | -0.0066543 |
| TMEM176A | transmembrane protein 176A | -0.00654635 |
| NPEPL1 | aminopeptidase-like 1 | -0.00653013 |
| MAMLD1 | mastermind-like domain containing 1 | -0.00651788 |
| TSPAN13 | tetraspanin 13 | -0.00649593 |
| CTSD | cathepsin D | -0.00647849 |
| SMAD7 | SMAD family member 7 | -0.00645751 |
| RPS27L | ribosomal protein S27-like | -0.0064482 |
| COX7A2 | cytochrome c oxidase subunit VIIa polypeptide 2 (liver) | -0.00639195 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | -0.00638855 |
| COPE | coatomer protein complex, subunit epsilon | -0.00632994 |
| TCTA | T-cell leukemia translocation altered | -0.006329 |
| TMEM176B | transmembrane protein 176B | -0.00631151 |
| GNAS | GNAS complex locus | -0.00628431 |
| AUTS2 | autism susceptibility candidate 2 | -0.00626805 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.00621669 |
| GPX1 | glutathione peroxidase 1 | -0.00621412 |
| PTK2 | protein tyrosine kinase 2 | -0.00619853 |
| MS4A6A | membrane-spanning 4-domains, subfamily A, member 6A | -0.00619515 |
| CD9 | CD9 molecule | -0.00616774 |
| PHYH | phytanoyl-CoA 2-hydroxylase | -0.00615149 |
| BSG | basigin (Ok blood group) | -0.00614521 |
| NDUFB1 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa | -0.00613355 |
| ITGB4 | integrin, beta 4 | -0.00612041 |
| TNS3 | tensin 3 | -0.00608983 |
| PCNA | proliferating cell nuclear antigen | -0.00607268 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | -0.00605009 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.00601927 |
| TMEM106B | transmembrane protein 106B | -0.00601338 |
| RRAS | related RAS viral (r-ras) oncogene homolog | -0.00601021 |
| AK1 | adenylate kinase 1 | -0.00597948 |
| PNMA2 | paraneoplastic Ma antigen 2 | -0.00597687 |
| TIMM8B | translocase of inner mitochondrial membrane 8 homolog B (yeast) | -0.0059337 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | -0.00588442 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.00587954 |
| ZNF91 | zinc finger protein 91 | -0.00587806 |
| WASHC4 | WASH complex subunit 4 | -0.00587621 |
| ADH5 | alcohol dehydrogenase 5 (class III), chi polypeptide | -0.0058513 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | -0.0058428 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | -0.00583469 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | -0.00583081 |
| RCAN2 | regulator of calcineurin 2 | -0.0057894 |
| ICAM2 | intercellular adhesion molecule 2 | -0.00578407 |
| CCDC85B | coiled-coil domain containing 85B | -0.00578178 |
| ATP5MF | ATP synthase membrane subunit f | -0.00577695 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.00574836 |
| CENPU | centromere protein U | -0.00572887 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.00572777 |
| TMEM47 | transmembrane protein 47 | -0.00572496 |
| MRPS33 | mitochondrial ribosomal protein S33 | -0.00571651 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | -0.00570524 |
| DPM3 | dolichyl-phosphate mannosyltransferase polypeptide 3 | -0.00569543 |
| IGFBP6 | insulin-like growth factor binding protein 6 | -0.00569378 |
| AKR7A3 | aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) | -0.00567588 |
| TIPRL | TOR signaling pathway regulator | -0.00565899 |
| MCOLN1 | mucolipin 1 | -0.00565475 |
| ACAT1 | acetyl-CoA acetyltransferase 1 | -0.0056047 |
| C1ORF54 | chromosome 1 open reading frame 54 | -0.00559137 |
| ICA1 | islet cell autoantigen 1, 69kDa | -0.00558649 |
| IPO13 | importin 13 | -0.0055817 |
| CDC20 | cell division cycle 20 | -0.00557999 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.00557368 |
| MRPL40 | mitochondrial ribosomal protein L40 | -0.00556423 |
| ZNF329 | zinc finger protein 329 | -0.00555516 |
| SPINK2 | serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) | -0.00549434 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.00546501 |
| CRYL1 | crystallin, lambda 1 | -0.00546134 |
| VSIG4 | V-set and immunoglobulin domain containing 4 | -0.00544832 |
| CADM1 | cell adhesion molecule 1 | -0.00544624 |
| TRIM22 | tripartite motif containing 22 | -0.00543946 |
| ST18 | suppression of tumorigenicity 18, zinc finger | -0.00543737 |
| COX7B | cytochrome c oxidase subunit VIIb | -0.00542745 |
| COMT | catechol-O-methyltransferase | -0.00542679 |
| C11ORF68 | chromosome 11 open reading frame 68 | -0.00542552 |
| SUGCT | succinyl-CoA:glutarate-CoA transferase | -0.00541089 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | -0.00540669 |
| PSMF1 | proteasome (prosome, macropain) inhibitor subunit 1 (PI31) | -0.00539569 |
| BGN | biglycan | -0.00537772 |
| TP53I3 | tumor protein p53 inducible protein 3 | -0.00537249 |
| TPGS2 | tubulin polyglutamylase complex subunit 2 | -0.00536192 |
| GZMK | granzyme K (granzyme 3; tryptase II) | -0.0053525 |
| TNFSF4 | tumor necrosis factor (ligand) superfamily, member 4 | -0.00534704 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | -0.00530752 |
| ASPA | aspartoacylase | -0.00530749 |
| GLUL | glutamate-ammonia ligase | -0.00530061 |
| NDUFA3 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa | -0.00528787 |
| CHN2 | chimerin 2 | -0.00528606 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.00528033 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.00527752 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.00525784 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.00525744 |
| NEBL | nebulette | -0.0052331 |
| NOX1 | NADPH oxidase 1 | -0.00523089 |
| DIPK1A | divergent protein kinase domain 1A | -0.00522069 |
| IFIT5 | interferon-induced protein with tetratricopeptide repeats 5 | -0.00521733 |
| STK39 | serine threonine kinase 39 | -0.00520658 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -0.00520095 |
| AASDHPPT | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | -0.00517866 |
| SOD3 | superoxide dismutase 3, extracellular | -0.005178 |
| AHR | aryl hydrocarbon receptor | -0.00516797 |
| CEL | carboxyl ester lipase | -0.00516728 |
| BCAT2 | branched chain amino-acid transaminase 2, mitochondrial | -0.00516353 |
| IGLL1 | immunoglobulin lambda-like polypeptide 1 | -0.00515311 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.00512326 |
| METTL5 | methyltransferase like 5 | -0.00511547 |
| SMAD6 | SMAD family member 6 | -0.0051127 |
| COPS7A | COP9 signalosome subunit 7A | -0.00510608 |
| PAM16 | presequence translocase-associated motor 16 homolog (S. cerevisiae) | -0.00510246 |
| MZB1 | marginal zone B and B1 cell-specific protein | -0.00510171 |
| APOC1 | apolipoprotein C-I | -0.00509696 |
| CRIP2 | cysteine-rich protein 2 | -0.00509222 |
| RMND1 | required for meiotic nuclear division 1 homolog (S. cerevisiae) | -0.00508775 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.00508498 |
| QDPR | quinoid dihydropteridine reductase | -0.00505795 |
| DNASE1L1 | deoxyribonuclease I-like 1 | -0.0050514 |
| POLR1D | polymerase (RNA) I polypeptide D, 16kDa | -0.00505133 |
| RNASE6 | ribonuclease, RNase A family, k6 | -0.00505127 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.00503801 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.00502884 |
| SLC66A2 | solute carrier family 66 member 2 | -0.00502379 |
| DET1 | de-etiolated homolog 1 (Arabidopsis) | -0.00501385 |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | -0.00501137 |
| NDUFB7 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa | -0.0050077 |
| HPGDS | hematopoietic prostaglandin D synthase | -0.00500566 |
| CD4 | CD4 molecule | -0.00500513 |
| GUK1 | guanylate kinase 1 | -0.00499486 |
| FAR2 | fatty acyl CoA reductase 2 | -0.00498626 |
| NPY | neuropeptide Y | -0.00498519 |
| ACOT13 | acyl-CoA thioesterase 13 | -0.00497007 |
| ACAN | aggrecan | -0.00496975 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | -0.00496802 |
| KRT19 | keratin 19, type I | -0.00496788 |
| LYL1 | lymphoblastic leukemia associated hematopoiesis regulator 1 | -0.00495604 |
| ZNF544 | zinc finger protein 544 | -0.00494288 |
| HS3ST2 | heparan sulfate (glucosamine) 3-O-sulfotransferase 2 | -0.00492523 |
| SCRG1 | stimulator of chondrogenesis 1 | -0.00492519 |
| CRLF1 | cytokine receptor-like factor 1 | -0.00492504 |
| MN1 | meningioma (disrupted in balanced translocation) 1 | -0.00491519 |
| GCHFR | GTP cyclohydrolase I feedback regulator | -0.00491228 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0049044 |
| SLA | Src-like-adaptor | -0.00488324 |
| SCG5 | secretogranin V | -0.00488025 |
| ALG5 | ALG5, dolichyl-phosphate beta-glucosyltransferase | -0.00484573 |
| LY86 | lymphocyte antigen 86 | -0.0048444 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -0.00484115 |
| NNMT | nicotinamide N-methyltransferase | -0.00483279 |
| FAAH | fatty acid amide hydrolase | -0.00482657 |
| PLN | phospholamban | -0.00482335 |
| ACAA2 | acetyl-CoA acyltransferase 2 | -0.00481728 |
| ZSCAN18 | zinc finger and SCAN domain containing 18 | -0.00481301 |
| CST3 | cystatin C | -0.00481218 |
| ZNF264 | zinc finger protein 264 | -0.00480693 |
| SLC27A2 | solute carrier family 27 (fatty acid transporter), member 2 | -0.00479393 |
| SORT1 | sortilin 1 | -0.00479338 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.00478865 |
| MEN1 | multiple endocrine neoplasia I | -0.0047885 |
| GSTO1 | glutathione S-transferase omega 1 | -0.00476571 |
| HOPX | HOP homeobox | -0.00476365 |
| RBX1 | ring-box 1, E3 ubiquitin protein ligase | -0.00475736 |
| POLR2D | polymerase (RNA) II (DNA directed) polypeptide D | -0.00475144 |
| SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) | -0.00474653 |
| MYO1D | myosin ID | -0.00473041 |
| ASS1 | argininosuccinate synthase 1 | -0.00472475 |
| TMEM140 | transmembrane protein 140 | -0.00472317 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.00472174 |
| STON1 | stonin 1 | -0.00471889 |
| TFEB | transcription factor EB | -0.00470657 |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | -0.00468356 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.00468185 |
| MYRF | myelin regulatory factor | -0.00467422 |
| LYPLA1 | lysophospholipase I | -0.00467387 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | -0.00467116 |
| DHFR | dihydrofolate reductase | -0.00466473 |
| CD48 | CD48 molecule | -0.00466458 |
| AP1S1 | adaptor-related protein complex 1, sigma 1 subunit | -0.00465725 |
| SNX11 | sorting nexin 11 | -0.00464291 |
| SFN | stratifin | -0.00463449 |
| MSLN | mesothelin | -0.00463283 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | -0.00462981 |
| CLEC7A | C-type lectin domain family 7, member A | -0.00462263 |
| ANXA4 | annexin A4 | -0.00462063 |
| LYRM4 | LYR motif containing 4 | -0.00461744 |
| LDOC1 | leucine zipper, down-regulated in cancer 1 | -0.00461511 |
| KCNJ8 | potassium channel, inwardly rectifying subfamily J, member 8 | -0.00461046 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | -0.00460175 |
| RBM34 | RNA binding motif protein 34 | -0.00459993 |
