PTEN Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description phosphatase and tensin homolog|This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015] (NCBI Entrez Gene Database, 5728)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/MORF_PTEN
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Genes

85 co-expressed genes for PTEN from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10
AQP7 aquaporin 7
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ATF2 activating transcription factor 2
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1
BRD1 bromodomain containing 1
CDYL chromodomain protein, Y-like
CNTN6 contactin 6
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPEB3 cytoplasmic polyadenylation element binding protein 3
CTRL chymotrypsin-like
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
ELAVL2 ELAV like neuron-specific RNA binding protein 2
FNTB farnesyltransferase, CAAX box, beta
FOSL1 FOS-like antigen 1
FRY furry homolog (Drosophila)
FRYL FRY-like
GJB5 gap junction protein, beta 5, 31.1kDa
GLE1 GLE1 RNA export mediator
GPATCH8 G patch domain containing 8
GPR19 G protein-coupled receptor 19
GRIK5 glutamate receptor, ionotropic, kainate 5
HNF1A HNF1 homeobox A
IGKV7-3 immunoglobulin kappa variable 7-3 (pseudogene)
IL13RA1 interleukin 13 receptor, alpha 1
IL16 interleukin 16
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
JADE3 jade family PHD finger 3
JRK Jrk homolog (mouse)
KIAA0586 KIAA0586
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast)
KRT2 keratin 2, type II
KRT33A keratin 33A, type I
KRT86 keratin 86, type II
MAGEA9 melanoma antigen family A9
MC5R melanocortin 5 receptor
MFN1 mitofusin 1
MGA MGA, MAX dimerization protein
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MSH3 mutS homolog 3
MSL3 male-specific lethal 3 homolog (Drosophila)
NFX1 nuclear transcription factor, X-box binding 1
NR1I2 nuclear receptor subfamily 1, group I, member 2
NRTN neurturin
NTNG2 netrin G2
P2RY10 purinergic receptor P2Y, G-protein coupled, 10
PAX9 paired box 9
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PHF10 PHD finger protein 10
PIAS2 protein inhibitor of activated STAT, 2
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
POU6F1 POU class 6 homeobox 1
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTBP3 polypyrimidine tract binding protein 3
PTEN phosphatase and tensin homolog
PVR poliovirus receptor
RAP2C RAP2C, member of RAS oncogene family
RBMXL1 RNA binding motif protein, X-linked-like 1
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SCAMP1 secretory carrier membrane protein 1
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
STAG1 stromal antigen 1
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SULT4A1 sulfotransferase family 4A, member 1
SYT5 synaptotagmin V
TBC1D22A TBC1 domain family, member 22A
TBX19 T-box 19
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TMEM11 transmembrane protein 11
UBE4B ubiquitination factor E4B
WBP4 WW domain binding protein 4
WIPF2 WAS/WASL interacting protein family, member 2
ZBTB14 zinc finger and BTB domain containing 14
ZBTB22 zinc finger and BTB domain containing 22
ZNF134 zinc finger protein 134
ZNF157 zinc finger protein 157
ZNF253 zinc finger protein 253
ZNF266 zinc finger protein 266
ZNF500 zinc finger protein 500
ZP2 zona pellucida glycoprotein 2 (sperm receptor)