PTEN Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description phosphatase and tensin homolog|This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015] (NCBI Entrez Gene Database, 5728)
External Link http://www.ncbi.nlm.nih.gov/gene/5728
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174 interacting proteins for PTEN from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABI1 abl-interactor 1
ABI2 abl-interactor 2
ADAP1 ArfGAP with dual PH domains 1
ADGRF3 adhesion G protein-coupled receptor F3
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
AMHR2 anti-Mullerian hormone receptor, type II
ANAPC4 anaphase promoting complex subunit 4
ANAPC5 anaphase promoting complex subunit 5
ANAPC7 anaphase promoting complex subunit 7
ANG angiogenin, ribonuclease, RNase A family, 5
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
APC adenomatous polyposis coli
AR androgen receptor
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARF6 ADP-ribosylation factor 6
ARHGAP26 Rho GTPase activating protein 26
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ATM ATM serine/threonine kinase
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BMI1 BMI1 proto-oncogene, polycomb ring finger
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit
BTK Bruton agammaglobulinemia tyrosine kinase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCNE2 cyclin E2
CDC27 cell division cycle 27
CDC42 cell division cycle 42
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHGB chromogranin B
COPS6 COP9 signalosome subunit 6
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYTH1 cytohesin 1
CYTH2 cytohesin 2
CYTH3 cytohesin 3
DBF4B DBF4 zinc finger B
DBN1 drebrin 1
DCC DCC netrin 1 receptor
DLG1 discs, large homolog 1 (Drosophila)
DOCK1 dedicator of cytokinesis 1
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
ECSCR endothelial cell surface expressed chemotaxis and apoptosis regulator
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFNB1 ephrin-B1
EFNB2 ephrin-B2
EFNB3 ephrin-B3
EGR1 early growth response 1
ELAVL1 ELAV like RNA binding protein 1
EPHB1 EPH receptor B1
EPHB2 EPH receptor B2
EPHB3 EPH receptor B3
EPHB4 EPH receptor B4
EPHB6 EPH receptor B6
EPS8 epidermal growth factor receptor pathway substrate 8
ESR1 estrogen receptor 1
EZR ezrin
FBN2 fibrillin 2
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FRK fyn-related Src family tyrosine kinase
FYN FYN proto-oncogene, Src family tyrosine kinase
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GAB1 GRB2-associated binding protein 1
GFRA2 GDNF family receptor alpha 2
GLTSCR2 glioma tumor suppressor candidate region gene 2
GSK3B glycogen synthase kinase 3 beta
GSN gelsolin
HBA2 hemoglobin, alpha 2
HRAS Harvey rat sarcoma viral oncogene homolog
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
INHBE inhibin, beta E
IRS4 insulin receptor substrate 4
ITK IL2-inducible T-cell kinase
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
ITSN1 intersectin 1 (SH3 domain protein)
KAT2B K(lysine) acetyltransferase 2B
KRT14 keratin 14, type I
LATS1 large tumor suppressor kinase 1
LCK LCK proto-oncogene, Src family tyrosine kinase
LYN LYN proto-oncogene, Src family tyrosine kinase
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3
MAP2K6 mitogen-activated protein kinase kinase 6
MAST1 microtubule associated serine/threonine kinase 1
MAST2 microtubule associated serine/threonine kinase 2
MAST3 microtubule associated serine/threonine kinase 3
MED12 mediator complex subunit 12
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MVP major vault protein
NCK1 NCK adaptor protein 1
NCKAP1 NCK-associated protein 1
NCOA3 nuclear receptor coactivator 3
NDFIP1 Nedd4 family interacting protein 1
NDFIP2 Nedd4 family interacting protein 2
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NTN1 netrin 1
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PARK7 parkinson protein 7
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDPK1 3-phosphoinositide dependent protein kinase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PINK1 PTEN induced putative kinase 1
PKN2 protein kinase N2
PLCG1 phospholipase C, gamma 1
PLK3 polo-like kinase 3
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRDX1 peroxiredoxin 1
PRKCZ protein kinase C, zeta
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN14 protein tyrosine phosphatase, non-receptor type 14
PXN paxillin
QRFPR pyroglutamylated RFamide peptide receptor
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAP1A RAP1A, member of RAS oncogene family
RAP1B RAP1B, member of RAS oncogene family
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPL14 ribosomal protein L14
RPS27A ribosomal protein S27a
SDC4 syndecan 4
SGK1 serum/glucocorticoid regulated kinase 1
SHARPIN SHANK-associated RH domain interactor
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SMTN smoothelin
SOS1 son of sevenless homolog 1 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT5A signal transducer and activator of transcription 5A
STK11 serine/threonine kinase 11
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUMO1 small ubiquitin-like modifier 1
SUMO3 small ubiquitin-like modifier 3
TCEB3C transcription elongation factor B polypeptide 3C (elongin A3)
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TP53 tumor protein p53
TRIO trio Rho guanine nucleotide exchange factor
TTBK2 tau tubulin kinase 2
UBC ubiquitin C
UBE2I ubiquitin-conjugating enzyme E2I
UBE2L3 ubiquitin-conjugating enzyme E2L 3
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
USP10 ubiquitin specific peptidase 10
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
USP39 ubiquitin specific peptidase 39
USP4 ubiquitin specific peptidase 4 (proto-oncogene)
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
USP8 ubiquitin specific peptidase 8
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
WAS Wiskott-Aldrich syndrome
WASF1 WAS protein family, member 1
WASF2 WAS protein family, member 2
WASL Wiskott-Aldrich syndrome-like
WNT4 wingless-type MMTV integration site family, member 4
WWP1 WW domain containing E3 ubiquitin protein ligase 1
WWP2 WW domain containing E3 ubiquitin protein ligase 2
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZNF787 zinc finger protein 787