PTEN_DN.V2 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
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282 genes differentially expressed following the PTEN_DN.V2 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
AHSP alpha hemoglobin stabilizing protein
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANGPTL4 angiopoietin-like 4
ANKMY1 ankyrin repeat and MYND domain containing 1
ANO2 anoctamin 2, calcium activated chloride channel
ANXA3 annexin A3
APOL3 apolipoprotein L, 3
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARL4C ADP-ribosylation factor-like 4C
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
BBC3 BCL2 binding component 3
BIRC3 baculoviral IAP repeat containing 3
BNC2 basonuclin 2
BUD31 BUD31 homolog (S. cerevisiae)
CA5B carbonic anhydrase VB, mitochondrial
CASP4 caspase 4, apoptosis-related cysteine peptidase
CCL16 chemokine (C-C motif) ligand 16
CD86 CD86 molecule
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21
CEP41 centrosomal protein 41kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRDL1 chordin-like 1
CHRM4 cholinergic receptor, muscarinic 4
CLIP4 CAP-GLY domain containing linker protein family, member 4
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
COL13A1 collagen, type XIII, alpha 1
CPA4 carboxypeptidase A4
CSF1 colony stimulating factor 1 (macrophage)
CTNNBIP1 catenin, beta interacting protein 1
CUEDC1 CUE domain containing 1
CXCL8 chemokine (C-X-C motif) ligand 8
DEFB126 defensin, beta 126
DENND2A DENN/MADD domain containing 2A
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
EHF ets homologous factor
EMP1 epithelial membrane protein 1
ERN2 endoplasmic reticulum to nucleus signaling 2
FYB FYN binding protein
G0S2 G0/G1 switch 2
GK3P glycerol kinase 3 pseudogene
GLRA2 glycine receptor, alpha 2
GMIP GEM interacting protein
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GPM6A glycoprotein M6A
GPR183 G protein-coupled receptor 183
GPR87 G protein-coupled receptor 87
GRID2 glutamate receptor, ionotropic, delta 2
GVINP1 GTPase, very large interferon inducible pseudogene 1
GYS2 glycogen synthase 2 (liver)
HSPA4L heat shock 70kDa protein 4-like
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular)
HSPB8 heat shock 22kDa protein 8
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
IL11RA interleukin 11 receptor, alpha
IL17A interleukin 17A
IL1B interleukin 1, beta
IL32 interleukin 32
IL4R interleukin 4 receptor
IL7R interleukin 7 receptor
JUN jun proto-oncogene
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
KLHL28 kelch-like family member 28
KLK10 kallikrein-related peptidase 10
KRT15 keratin 15, type I
KRT32 keratin 32, type I
KRT75 keratin 75, type II
KRT8P12 keratin 8 pseudogene 12
LAMA3 laminin, alpha 3
LCN2 lipocalin 2
LIG4 ligase IV, DNA, ATP-dependent
LIPG lipase, endothelial
LOC440895 two pore channel 3 pseudogene
LOXL2 lysyl oxidase-like 2
LSP1 lymphocyte-specific protein 1
MC3R melanocortin 3 receptor
MIR22HG MIR22 host gene
MON1B MON1 secretory trafficking family member B
MPV17 MpV17 mitochondrial inner membrane protein
MYL10 myosin, light chain 10, regulatory
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NAV3 neuron navigator 3
NID2 nidogen 2 (osteonidogen)
NNAT neuronatin
NOL4 nucleolar protein 4
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
OSGIN1 oxidative stress induced growth inhibitor 1
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
OVGP1 oviductal glycoprotein 1, 120kDa
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PC pyruvate carboxylase
PCSK7 proprotein convertase subtilisin/kexin type 7
PLAU plasminogen activator, urokinase
PPAP2B phosphatidic acid phosphatase type 2B
PQLC3 PQ loop repeat containing 3
PRKY protein kinase, Y-linked, pseudogene
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RND1 Rho family GTPase 1
RTN1 reticulon 1
SAMD4A sterile alpha motif domain containing 4A
SATB1 SATB homeobox 1
SECTM1 secreted and transmembrane 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SH3BGR SH3 domain binding glutamate-rich protein
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SLITRK3 SLIT and NTRK-like family, member 3
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
TBX5 T-box 5
THBS4 thrombospondin 4
TIGAR TP53 induced glycolysis regulatory phosphatase
TMEM127 transmembrane protein 127
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TP53I3 tumor protein p53 inducible protein 3
TRIB2 tribbles pseudokinase 2
TSHB thyroid stimulating hormone, beta
ULK4 unc-51 like kinase 4
UPK2 uroplakin 2
UTRN utrophin
VAMP5 vesicle-associated membrane protein 5
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
WT1-AS WT1 antisense RNA
ZMAT3 zinc finger, matrin-type 3
ZMAT5 zinc finger, matrin-type 5
ZNF549 zinc finger protein 549
ZNF668 zinc finger protein 668

decreased expression

Symbol Name
ABLIM2 actin binding LIM protein family, member 2
ADCK3 aarF domain containing kinase 3
AHSA2 AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)
AKAP5 A kinase (PRKA) anchor protein 5
ANXA10 annexin A10
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
AP4M1 adaptor-related protein complex 4, mu 1 subunit
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
APOLD1 apolipoprotein L domain containing 1
ARHGAP33 Rho GTPase activating protein 33
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ASB7 ankyrin repeat and SOCS box containing 7
ATF5 activating transcription factor 5
ATP11B ATPase, class VI, type 11B
BAHCC1 BAH domain and coiled-coil containing 1
BAMBI BMP and activin membrane-bound inhibitor
BARD1 BRCA1 associated RING domain 1
BARX2 BARX homeobox 2
BATF3 basic leucine zipper transcription factor, ATF-like 3
BCOR BCL6 corepressor
BMP4 bone morphogenetic protein 4
CBX7 chromobox homolog 7
CCDC132 coiled-coil domain containing 132
CCDC53 coiled-coil domain containing 53
CCDC88C coiled-coil domain containing 88C
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CLEC7A C-type lectin domain family 7, member A
COPZ2 coatomer protein complex, subunit zeta 2
CORO2B coronin, actin binding protein, 2B
CRBN cereblon
CRIP2 cysteine-rich protein 2
CRYAA crystallin, alpha A
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLX2 distal-less homeobox 2
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
ELANE elastase, neutrophil expressed
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EVA1B eva-1 homolog B (C. elegans)
FABP6 fatty acid binding protein 6, ileal
FANCA Fanconi anemia, complementation group A
FCAR Fc fragment of IgA receptor
FES FES proto-oncogene, tyrosine kinase
FGFR3 fibroblast growth factor receptor 3
FOXH1 forkhead box H1
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
FRMD1 FERM domain containing 1
GFM1 G elongation factor, mitochondrial 1
GPR3 G protein-coupled receptor 3
GPRC5C G protein-coupled receptor, class C, group 5, member C
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GUSBP11 glucuronidase, beta pseudogene 11
HBA2 hemoglobin, alpha 2
HCLS1 hematopoietic cell-specific Lyn substrate 1
HIST1H3D histone cluster 1, H3d
HIST1H4E histone cluster 1, H4e
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HNF1A HNF1 homeobox A
HOXB13 homeobox B13
HOXC5 homeobox C5
IRS4 insulin receptor substrate 4
IZUMO4 IZUMO family member 4
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KLHL11 kelch-like family member 11
KRT23 keratin 23, type I
KRT7 keratin 7, type II
LINC00339 long intergenic non-protein coding RNA 339
LOXL1 lysyl oxidase-like 1
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
MAGOHB mago-nashi homolog B (Drosophila)
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK3 mitogen-activated protein kinase 3
MEGF8 multiple EGF-like-domains 8
MGA MGA, MAX dimerization protein
MID1 midline 1
MRC2 mannose receptor, C type 2
MT1M metallothionein 1M
MXD3 MAX dimerization protein 3
NDOR1 NADPH dependent diflavin oxidoreductase 1
NEO1 neogenin 1
NIPAL3 NIPA-like domain containing 3
NOS3 nitric oxide synthase 3 (endothelial cell)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NREP neuronal regeneration related protein
NRTN neurturin
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
NVL nuclear VCP-like
OGDHL oxoglutarate dehydrogenase-like
OR2H1 olfactory receptor, family 2, subfamily H, member 1
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PIDD1 p53-induced death domain protein 1
PLAG1 pleiomorphic adenoma gene 1
PLEKHO1 pleckstrin homology domain containing, family O member 1
PRMT7 protein arginine methyltransferase 7
PTEN phosphatase and tensin homolog
PVRL3 poliovirus receptor-related 3
RASA3 RAS p21 protein activator 3
RBM4 RNA binding motif protein 4
RECQL4 RecQ protein-like 4
REPS2 RALBP1 associated Eps domain containing 2
RGS2 regulator of G-protein signaling 2
RIBC2 RIB43A domain with coiled-coils 2
RIC3 RIC3 acetylcholine receptor chaperone
RIT2 Ras-like without CAAX 2
RPS4Y1 ribosomal protein S4, Y-linked 1
SCGN secretagogin, EF-hand calcium binding protein
SEPP1 selenoprotein P, plasma, 1
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SGK1 serum/glucocorticoid regulated kinase 1
SMAD7 SMAD family member 7
SPDEF SAM pointed domain containing ETS transcription factor
SPDL1 spindle apparatus coiled-coil protein 1
SPHK1 sphingosine kinase 1
SSTR5 somatostatin receptor 5
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STMN1 stathmin 1
TACC2 transforming, acidic coiled-coil containing protein 2
TBX3 T-box 3
TERT telomerase reverse transcriptase
TEX13B testis expressed 13B
TGFBI transforming growth factor, beta-induced, 68kDa
THEM6 thioesterase superfamily member 6
TMEM176A transmembrane protein 176A
TRAF2 TNF receptor-associated factor 2
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TUBB1 tubulin, beta 1 class VI
TUBBP5 tubulin, beta pseudogene 5
TULP1 tubby like protein 1
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
UNC119 unc-119 homolog (C. elegans)
WIPF1 WAS/WASL interacting protein family, member 1
ZFY zinc finger protein, Y-linked
ZNF124 zinc finger protein 124
ZNF446 zinc finger protein 446
ZNF574 zinc finger protein 574