| Dataset | MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database) |
| External Link | http://www.broadinstitute.org/gsea/msigdb/cards/PTEN_DN.V2_UP |
| Similar Terms | |
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282 genes differentially expressed following the PTEN_DN.V2 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
| Symbol | Name |
|---|---|
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 |
| AHSP | alpha hemoglobin stabilizing protein |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) |
| AKR1C3 | aldo-keto reductase family 1, member C3 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 |
| ANGPTL4 | angiopoietin-like 4 |
| ANKMY1 | ankyrin repeat and MYND domain containing 1 |
| ANO2 | anoctamin 2, calcium activated chloride channel |
| ANXA3 | annexin A3 |
| APOL3 | apolipoprotein L, 3 |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta |
| ARHGEF5 | Rho guanine nucleotide exchange factor (GEF) 5 |
| ARL4C | ADP-ribosylation factor-like 4C |
| ARVCF | armadillo repeat gene deleted in velocardiofacial syndrome |
| ATP2B2 | ATPase, Ca++ transporting, plasma membrane 2 |
| BBC3 | BCL2 binding component 3 |
| BIRC3 | baculoviral IAP repeat containing 3 |
| BNC2 | basonuclin 2 |
| BUD31 | BUD31 homolog (S. cerevisiae) |
| CA5B | carbonic anhydrase VB, mitochondrial |
| CASP4 | caspase 4, apoptosis-related cysteine peptidase |
| CCL16 | chemokine (C-C motif) ligand 16 |
| CD86 | CD86 molecule |
| CEACAM21 | carcinoembryonic antigen-related cell adhesion molecule 21 |
| CEP41 | centrosomal protein 41kDa |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 |
| CHRDL1 | chordin-like 1 |
| CHRM4 | cholinergic receptor, muscarinic 4 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 |
| CLPB | ClpB homolog, mitochondrial AAA ATPase chaperonin |
| COL13A1 | collagen, type XIII, alpha 1 |
| CPA4 | carboxypeptidase A4 |
| CSF1 | colony stimulating factor 1 (macrophage) |
| CTNNBIP1 | catenin, beta interacting protein 1 |
| CUEDC1 | CUE domain containing 1 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 |
| DEFB126 | defensin, beta 126 |
| DENND2A | DENN/MADD domain containing 2A |
| DGCR11 | DiGeorge syndrome critical region gene 11 (non-protein coding) |
| DNAJB5 | DnaJ (Hsp40) homolog, subfamily B, member 5 |
| EHF | ets homologous factor |
| EMP1 | epithelial membrane protein 1 |
| ERN2 | endoplasmic reticulum to nucleus signaling 2 |
| FYB | FYN binding protein |
| G0S2 | G0/G1 switch 2 |
| GK3P | glycerol kinase 3 pseudogene |
| GLRA2 | glycine receptor, alpha 2 |
| GMIP | GEM interacting protein |
| GNA14 | guanine nucleotide binding protein (G protein), alpha 14 |
| GPM6A | glycoprotein M6A |
| GPR183 | G protein-coupled receptor 183 |
| GPR87 | G protein-coupled receptor 87 |
| GRID2 | glutamate receptor, ionotropic, delta 2 |
| GVINP1 | GTPase, very large interferon inducible pseudogene 1 |
| GYS2 | glycogen synthase 2 (liver) |
| HSPA4L | heat shock 70kDa protein 4-like |
| HSPB7 | heat shock 27kDa protein family, member 7 (cardiovascular) |
| HSPB8 | heat shock 22kDa protein 8 |
| HTR1B | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled |
| IL11RA | interleukin 11 receptor, alpha |
| IL17A | interleukin 17A |
| IL1B | interleukin 1, beta |
| IL32 | interleukin 32 |
| IL4R | interleukin 4 receptor |
| IL7R | interleukin 7 receptor |
| JUN | jun proto-oncogene |
| KCNJ3 | potassium channel, inwardly rectifying subfamily J, member 3 |
| KLHL28 | kelch-like family member 28 |
| KLK10 | kallikrein-related peptidase 10 |
| KRT15 | keratin 15, type I |
| KRT32 | keratin 32, type I |
| KRT75 | keratin 75, type II |
| KRT8P12 | keratin 8 pseudogene 12 |
| LAMA3 | laminin, alpha 3 |
| LCN2 | lipocalin 2 |
| LIG4 | ligase IV, DNA, ATP-dependent |
| LIPG | lipase, endothelial |
| LOC440895 | two pore channel 3 pseudogene |
| LOXL2 | lysyl oxidase-like 2 |
| LSP1 | lymphocyte-specific protein 1 |
| MC3R | melanocortin 3 receptor |
| MIR22HG | MIR22 host gene |
| MON1B | MON1 secretory trafficking family member B |
| MPV17 | MpV17 mitochondrial inner membrane protein |
| MYL10 | myosin, light chain 10, regulatory |
| NAALAD2 | N-acetylated alpha-linked acidic dipeptidase 2 |
| NAV3 | neuron navigator 3 |
| NID2 | nidogen 2 (osteonidogen) |
| NNAT | neuronatin |
| NOL4 | nucleolar protein 4 |
| OR12D2 | olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene) |
| OSGIN1 | oxidative stress induced growth inhibitor 1 |
| OTUB2 | OTU deubiquitinase, ubiquitin aldehyde binding 2 |
| OVGP1 | oviductal glycoprotein 1, 120kDa |
| P2RY2 | purinergic receptor P2Y, G-protein coupled, 2 |
| PC | pyruvate carboxylase |
| PCSK7 | proprotein convertase subtilisin/kexin type 7 |
| PLAU | plasminogen activator, urokinase |
| PPAP2B | phosphatidic acid phosphatase type 2B |
| PQLC3 | PQ loop repeat containing 3 |
| PRKY | protein kinase, Y-linked, pseudogene |
| PTGDS | prostaglandin D2 synthase 21kDa (brain) |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
| RHBDF1 | rhomboid 5 homolog 1 (Drosophila) |
| RND1 | Rho family GTPase 1 |
| RTN1 | reticulon 1 |
| SAMD4A | sterile alpha motif domain containing 4A |
| SATB1 | SATB homeobox 1 |
| SECTM1 | secreted and transmembrane 1 |
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 |
| SH3BGR | SH3 domain binding glutamate-rich protein |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 |
| SLC2A4 | solute carrier family 2 (facilitated glucose transporter), member 4 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 |
| SLITRK3 | SLIT and NTRK-like family, member 3 |
| SPAM1 | sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) |
| SPIB | Spi-B transcription factor (Spi-1/PU.1 related) |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 |
| ST3GAL4 | ST3 beta-galactoside alpha-2,3-sialyltransferase 4 |
| TBX5 | T-box 5 |
| THBS4 | thrombospondin 4 |
| TIGAR | TP53 induced glycolysis regulatory phosphatase |
| TMEM127 | transmembrane protein 127 |
| TNFRSF10C | tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain |
| TP53I3 | tumor protein p53 inducible protein 3 |
| TRIB2 | tribbles pseudokinase 2 |
| TSHB | thyroid stimulating hormone, beta |
| ULK4 | unc-51 like kinase 4 |
| UPK2 | uroplakin 2 |
| UTRN | utrophin |
| VAMP5 | vesicle-associated membrane protein 5 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) |
| WT1-AS | WT1 antisense RNA |
| ZMAT3 | zinc finger, matrin-type 3 |
| ZMAT5 | zinc finger, matrin-type 5 |
| ZNF549 | zinc finger protein 549 |
| ZNF668 | zinc finger protein 668 |
| Symbol | Name |
|---|---|
| ABLIM2 | actin binding LIM protein family, member 2 |
| ADCK3 | aarF domain containing kinase 3 |
| AHSA2 | AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast) |
| AKAP5 | A kinase (PRKA) anchor protein 5 |
| ANXA10 | annexin A10 |
| AP1G2 | adaptor-related protein complex 1, gamma 2 subunit |
| AP4M1 | adaptor-related protein complex 4, mu 1 subunit |
| APBB1IP | amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein |
| APOLD1 | apolipoprotein L domain containing 1 |
| ARHGAP33 | Rho GTPase activating protein 33 |
| ARHGEF40 | Rho guanine nucleotide exchange factor (GEF) 40 |
| ASB7 | ankyrin repeat and SOCS box containing 7 |
| ATF5 | activating transcription factor 5 |
| ATP11B | ATPase, class VI, type 11B |
| BAHCC1 | BAH domain and coiled-coil containing 1 |
| BAMBI | BMP and activin membrane-bound inhibitor |
| BARD1 | BRCA1 associated RING domain 1 |
| BARX2 | BARX homeobox 2 |
| BATF3 | basic leucine zipper transcription factor, ATF-like 3 |
| BCOR | BCL6 corepressor |
| BMP4 | bone morphogenetic protein 4 |
| CBX7 | chromobox homolog 7 |
| CCDC132 | coiled-coil domain containing 132 |
| CCDC53 | coiled-coil domain containing 53 |
| CCDC88C | coiled-coil domain containing 88C |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha |
| CHST12 | carbohydrate (chondroitin 4) sulfotransferase 12 |
| CLEC7A | C-type lectin domain family 7, member A |
| COPZ2 | coatomer protein complex, subunit zeta 2 |
| CORO2B | coronin, actin binding protein, 2B |
| CRBN | cereblon |
| CRIP2 | cysteine-rich protein 2 |
| CRYAA | crystallin, alpha A |
| CYP11B2 | cytochrome P450, family 11, subfamily B, polypeptide 2 |
| CYP20A1 | cytochrome P450, family 20, subfamily A, polypeptide 1 |
| DDX31 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 |
| DLX2 | distal-less homeobox 2 |
| DYRK4 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 |
| ELANE | elastase, neutrophil expressed |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 |
| EVA1B | eva-1 homolog B (C. elegans) |
| FABP6 | fatty acid binding protein 6, ileal |
| FANCA | Fanconi anemia, complementation group A |
| FCAR | Fc fragment of IgA receptor |
| FES | FES proto-oncogene, tyrosine kinase |
| FGFR3 | fibroblast growth factor receptor 3 |
| FOXH1 | forkhead box H1 |
| FRAT1 | frequently rearranged in advanced T-cell lymphomas 1 |
| FRMD1 | FERM domain containing 1 |
| GFM1 | G elongation factor, mitochondrial 1 |
| GPR3 | G protein-coupled receptor 3 |
| GPRC5C | G protein-coupled receptor, class C, group 5, member C |
| GTF3C5 | general transcription factor IIIC, polypeptide 5, 63kDa |
| GUSBP11 | glucuronidase, beta pseudogene 11 |
| HBA2 | hemoglobin, alpha 2 |
| HCLS1 | hematopoietic cell-specific Lyn substrate 1 |
| HIST1H3D | histone cluster 1, H3d |
| HIST1H4E | histone cluster 1, H4e |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 |
| HNF1A | HNF1 homeobox A |
| HOXB13 | homeobox B13 |
| HOXC5 | homeobox C5 |
| IRS4 | insulin receptor substrate 4 |
| IZUMO4 | IZUMO family member 4 |
| KCNE2 | potassium channel, voltage gated subfamily E regulatory beta subunit 2 |
| KLHL11 | kelch-like family member 11 |
| KRT23 | keratin 23, type I |
| KRT7 | keratin 7, type II |
| LINC00339 | long intergenic non-protein coding RNA 339 |
| LOXL1 | lysyl oxidase-like 1 |
| MAFK | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K |
| MAGOHB | mago-nashi homolog B (Drosophila) |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 |
| MAPK3 | mitogen-activated protein kinase 3 |
| MEGF8 | multiple EGF-like-domains 8 |
| MGA | MGA, MAX dimerization protein |
| MID1 | midline 1 |
| MRC2 | mannose receptor, C type 2 |
| MT1M | metallothionein 1M |
| MXD3 | MAX dimerization protein 3 |
| NDOR1 | NADPH dependent diflavin oxidoreductase 1 |
| NEO1 | neogenin 1 |
| NIPAL3 | NIPA-like domain containing 3 |
| NOS3 | nitric oxide synthase 3 (endothelial cell) |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 |
| NREP | neuronal regeneration related protein |
| NRTN | neurturin |
| NUDT18 | nudix (nucleoside diphosphate linked moiety X)-type motif 18 |
| NVL | nuclear VCP-like |
| OGDHL | oxoglutarate dehydrogenase-like |
| OR2H1 | olfactory receptor, family 2, subfamily H, member 1 |
| PCSK1N | proprotein convertase subtilisin/kexin type 1 inhibitor |
| PIDD1 | p53-induced death domain protein 1 |
| PLAG1 | pleiomorphic adenoma gene 1 |
| PLEKHO1 | pleckstrin homology domain containing, family O member 1 |
| PRMT7 | protein arginine methyltransferase 7 |
| PTEN | phosphatase and tensin homolog |
| PVRL3 | poliovirus receptor-related 3 |
| RASA3 | RAS p21 protein activator 3 |
| RBM4 | RNA binding motif protein 4 |
| RECQL4 | RecQ protein-like 4 |
| REPS2 | RALBP1 associated Eps domain containing 2 |
| RGS2 | regulator of G-protein signaling 2 |
| RIBC2 | RIB43A domain with coiled-coils 2 |
| RIC3 | RIC3 acetylcholine receptor chaperone |
| RIT2 | Ras-like without CAAX 2 |
| RPGRIP1L | RPGRIP1-like |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 |
| SCGN | secretagogin, EF-hand calcium binding protein |
| SEPP1 | selenoprotein P, plasma, 1 |
| SERPINA6 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 |
| SERPINH1 | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) |
| SGK1 | serum/glucocorticoid regulated kinase 1 |
| SMAD7 | SMAD family member 7 |
| SPDEF | SAM pointed domain containing ETS transcription factor |
| SPDL1 | spindle apparatus coiled-coil protein 1 |
| SPHK1 | sphingosine kinase 1 |
| SSTR5 | somatostatin receptor 5 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 |
| STMN1 | stathmin 1 |
| TACC2 | transforming, acidic coiled-coil containing protein 2 |
| TBX3 | T-box 3 |
| TERT | telomerase reverse transcriptase |
| TEX13B | testis expressed 13B |
| TGFBI | transforming growth factor, beta-induced, 68kDa |
| THEM6 | thioesterase superfamily member 6 |
| TMEM176A | transmembrane protein 176A |
| TRAF2 | TNF receptor-associated factor 2 |
| TRPM4 | transient receptor potential cation channel, subfamily M, member 4 |
| TUBB1 | tubulin, beta 1 class VI |
| TUBBP5 | tubulin, beta pseudogene 5 |
| TULP1 | tubby like protein 1 |
| UCP3 | uncoupling protein 3 (mitochondrial, proton carrier) |
| UNC119 | unc-119 homolog (C. elegans) |
| WIPF1 | WAS/WASL interacting protein family, member 1 |
| ZFY | zinc finger protein, Y-linked |
| ZNF124 | zinc finger protein 124 |
| ZNF446 | zinc finger protein 446 |
| ZNF574 | zinc finger protein 574 |
