PTGS2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)|Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009] (NCBI Entrez Gene Database, 5743)
External Link http://www.ncbi.nlm.nih.gov/gene/5743
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Genes

184 interacting proteins for PTGS2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ABHD16A abhydrolase domain containing 16A
ACLY ATP citrate lyase
ACSL5 acyl-CoA synthetase long-chain family member 5
ACTA1 actin, alpha 1, skeletal muscle
ACTG1 actin gamma 1
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
ADCK3 aarF domain containing kinase 3
AFG3L2 AFG3-like AAA ATPase 2
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
ALDH8A1 aldehyde dehydrogenase 8 family, member A1
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
AP2M1 adaptor-related protein complex 2, mu 1 subunit
AP3B1 adaptor-related protein complex 3, beta 1 subunit
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
CALML5 calmodulin-like 5
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CAV1 caveolin 1, caveolae protein, 22kDa
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CDK2 cyclin-dependent kinase 2
CELF2 CUGBP, Elav-like family member 2
CKAP5 cytoskeleton associated protein 5
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
COPE coatomer protein complex, subunit epsilon
COPG2 coatomer protein complex, subunit gamma 2
COPS3 COP9 signalosome subunit 3
COPS5 COP9 signalosome subunit 5
COPS7A COP9 signalosome subunit 7A
COX6C cytochrome c oxidase subunit VIc
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL1 cullin 1
CUL4A cullin 4A
CYFIP1 cytoplasmic FMR1 interacting protein 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDB1 damage-specific DNA binding protein 1, 127kDa
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DERL1 derlin 1
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16
DIAPH1 diaphanous-related formin 1
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3
EEF1G eukaryotic translation elongation factor 1 gamma
EEF2 eukaryotic translation elongation factor 2
EFTUD2 elongation factor Tu GTP binding domain containing 2
EIF3L eukaryotic translation initiation factor 3, subunit L
ELAVL1 ELAV like RNA binding protein 1
ELMO1 engulfment and cell motility 1
EP300 E1A binding protein p300
ERBB2 erb-b2 receptor tyrosine kinase 2
FARSA phenylalanyl-tRNA synthetase, alpha subunit
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GTF2I general transcription factor IIi
HACD3 3-hydroxyacyl-CoA dehydratase 3
HELLS helicase, lymphoid-specific
HIST1H2BB histone cluster 1, H2bb
HIST2H2AA4 histone cluster 2, H2aa4
HK1 hexokinase 1
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9)
HNRNPR heterogeneous nuclear ribonucleoprotein R
HSPB1 heat shock 27kDa protein 1
IGHA1 immunoglobulin heavy constant alpha 1
IGKC immunoglobulin kappa constant
IPO5 importin 5
IQGAP3 IQ motif containing GTPase activating protein 3
KHSRP KH-type splicing regulatory protein
KIF2A kinesin heavy chain member 2A
KPNB1 karyopherin (importin) beta 1
LAS1L LAS1-like (S. cerevisiae)
LBR lamin B receptor
LDHA lactate dehydrogenase A
LDHAL6A lactate dehydrogenase A-like 6A
LDHB lactate dehydrogenase B
LRRC47 leucine rich repeat containing 47
LRRK2 leucine-rich repeat kinase 2
MAGED2 melanoma antigen family D2
MAPK3 mitogen-activated protein kinase 3
MCM3 minichromosome maintenance complex component 3
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae)
MOGS mannosyl-oligosaccharide glucosidase
MSH2 mutS homolog 2
MSH5 mutS homolog 5
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYL1 myosin, light chain 1, alkali; skeletal, fast
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
MYO1B myosin IB
MYO1C myosin IC
MYO1D myosin ID
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCLN nicalin
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa
NOMO2 NODAL modulator 2
NTPCR nucleoside-triphosphatase, cancer-related
NUCB1 nucleobindin 1
NUCLEOLIN nucleolin multifunctional protein
NUP107 nucleoporin 107kDa
NUP133 nucleoporin 133kDa
NUP160 nucleoporin 160kDa
PCNA proliferating cell nuclear antigen
PFKP phosphofructokinase, platelet
PGM3 phosphoglucomutase 3
PHB prohibitin
PKM pyruvate kinase, muscle
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
PRPF6 pre-mRNA processing factor 6
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PTCD3 pentatricopeptide repeat domain 3
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PYCR1 pyrroline-5-carboxylate reductase 1
PYGB phosphorylase, glycogen; brain
RBM39 RNA binding motif protein 39
RBX1 ring-box 1, E3 ubiquitin protein ligase
RPL10A ribosomal protein L10a
RPL11 ribosomal protein L11
RPL12 ribosomal protein L12
RPL13 ribosomal protein L13
RPL14 ribosomal protein L14
RPL19 ribosomal protein L19
RPL23 ribosomal protein L23
RPL23A ribosomal protein L23a
RPL24 ribosomal protein L24
RPL3 ribosomal protein L3
RPLP0 ribosomal protein, large, P0
RPS11 ribosomal protein S11
RPS14 ribosomal protein S14
RPS15A ribosomal protein S15a
RPS16 ribosomal protein S16
RPS19 ribosomal protein S19
RPS2 ribosomal protein S2
RPS20 ribosomal protein S20
RPS23 ribosomal protein S23
RPS27 ribosomal protein S27
RPS3 ribosomal protein S3
RPS3A ribosomal protein S3A
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS5 ribosomal protein S5
RPS7 ribosomal protein S7
RPS8 ribosomal protein S8
SAMHD1 SAM domain and HD domain 1
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
SF3B2 splicing factor 3b, subunit 2, 145kDa
SF3B3 splicing factor 3b, subunit 3, 130kDa
SFXN1 sideroflexin 1
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLFN5 schlafen family member 5
SMAP1 small ArfGAP 1
SPTLC1 serine palmitoyltransferase, long chain base subunit 1
SSR4 signal sequence receptor, delta
SUMO1 small ubiquitin-like modifier 1
THOC1 THO complex 1
TOR1AIP1 torsin A interacting protein 1
TP53 tumor protein p53
TRAP1 TNF receptor-associated protein 1
TROVE2 TROVE domain family, member 2
TUBA1A tubulin, alpha 1a
TUBG1 tubulin, gamma 1
TUFM Tu translation elongation factor, mitochondrial
UBC ubiquitin C
UBE3C ubiquitin protein ligase E3C
VCP valosin containing protein
VIMP VCP-interacting membrane selenoprotein
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)
WASF1 WAS protein family, member 1
WASF2 WAS protein family, member 2
WDR5 WD repeat domain 5
YME1L1 YME1-like 1 ATPase
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36 ZFP36 ring finger protein