PTK2 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description protein tyrosine kinase 2|This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq, Dec 2010] (NCBI Entrez Gene Database, 5747)
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17 substrates of the kinase PTK2 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
ACTN1 actinin, alpha 1
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BCAR1 breast cancer anti-estrogen resistance 1
CDCP1 CUB domain containing protein 1
CTTN cortactin
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GRB7 growth factor receptor-bound protein 7
ITGB7 integrin, beta 7
NANOG Nanog homeobox
PTK2 protein tyrosine kinase 2
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RET ret proto-oncogene
SH3GL1 SH3-domain GRB2-like 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
TRIO trio Rho guanine nucleotide exchange factor
WASL Wiskott-Aldrich syndrome-like