PTK6 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description protein tyrosine kinase 6|The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] (NCBI Entrez Gene Database, 5753)
External Link http://www.ncbi.nlm.nih.gov/gene/5753
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Genes

70 interacting proteins for PTK6 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACVR1 activin A receptor, type I
ACVR2A activin A receptor, type IIA
ACVR2B activin A receptor, type IIB
ADAM15 ADAM metallopeptidase domain 15
AKT1 v-akt murine thymoma viral oncogene homolog 1
APP amyloid beta (A4) precursor protein
AR androgen receptor
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARHGAP5 Rho GTPase activating protein 5
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
AURKA aurora kinase A
AURKB aurora kinase B
BCAR1 breast cancer anti-estrogen resistance 1
BRAF B-Raf proto-oncogene, serine/threonine kinase
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CSK c-src tyrosine kinase
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
EGFR epidermal growth factor receptor
EPHA2 EPH receptor A2
EPHA7 EPH receptor A7
EPHB2 EPH receptor B2
EPHB4 EPH receptor B4
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FER fer (fps/fes related) tyrosine kinase
FGFR1 fibroblast growth factor receptor 1
FRK fyn-related Src family tyrosine kinase
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB1 GRB2-associated binding protein 1
GAK cyclin G associated kinase
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HTT huntingtin
IRS1 insulin receptor substrate 1
IRS4 insulin receptor substrate 4
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LYN LYN proto-oncogene, Src family tyrosine kinase
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MET MET proto-oncogene, receptor tyrosine kinase
MTOR mechanistic target of rapamycin (serine/threonine kinase)
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PLK4 polo-like kinase 4
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PXN paxillin
RIPK2 receptor-interacting serine-threonine kinase 2
SFPQ splicing factor proline/glutamine-rich
SOCS3 suppressor of cytokine signaling 3
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAP2 signal transducing adaptor family member 2
STAT5B signal transducer and activator of transcription 5B
STK16 serine/threonine kinase 16
TEC tec protein tyrosine kinase
TGFBR1 transforming growth factor, beta receptor 1
TNK1 tyrosine kinase, non-receptor, 1
UBC ubiquitin C
ULK3 unc-51 like kinase 3
YES1 YES proto-oncogene 1, Src family tyrosine kinase