PTP1B_KO_EGF vs basal_MEF (Mouse) [18515860] Gene Set

Dataset SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands
Category proteomics
Type ligand (protein) perturbation
Description ligand (protein) perturbation identified as [ligand perturbation]_[cell line] ([organism]) [[publication PMID]] (SILAC Phosphoproteomics)
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Genes

71 proteins differentially phosphorylated following the PTP1B_KO_EGF vs basal_MEF (Mouse) [18515860] ligand (protein) perturbation from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands dataset.

increased phosphorylation

Symbol Name
ADGRL2 adhesion G protein-coupled receptor L2
ANKRD13A ankyrin repeat domain 13A
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ARHGAP5 Rho GTPase activating protein 5
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CTNND1 catenin (cadherin-associated protein), delta 1
CTTN cortactin
CYLD cylindromatosis (turban tumor syndrome)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDR2 discoidin domain receptor tyrosine kinase 2
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
EGFR epidermal growth factor receptor
EPHA4 EPH receptor A4
EPHB2 EPH receptor B2
EPHB3 EPH receptor B3
EPN2 epsin 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FER fer (fps/fes related) tyrosine kinase
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
GAREM GRB2 associated, regulator of MAPK1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GJA1 gap junction protein, alpha 1, 43kDa
GRB2 growth factor receptor-bound protein 2
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
IFITM3 interferon induced transmembrane protein 3
INPPL1 inositol polyphosphate phosphatase-like 1
ITSN2 intersectin 2
KIRREL kin of IRRE like (Drosophila)
LPP LIM domain containing preferred translocation partner in lipoma
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MEGF10 multiple EGF-like-domains 10
PARD3 par-3 family cell polarity regulator
PDGFA platelet-derived growth factor alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PEAK1 pseudopodium-enriched atypical kinase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLCG1 phospholipase C, gamma 1
PTK2 protein tyrosine kinase 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
RAB1A RAB1A, member RAS oncogene family
SH3PXD2A SH3 and PX domains 2A
SHANK2 SH3 and multiple ankyrin repeat domains 2
SHB Src homology 2 domain containing adaptor protein B
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC38A2 solute carrier family 38, member 2
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TJP1 tight junction protein 1
TNK2 tyrosine kinase, non-receptor, 2
TNS1 tensin 1
TNS2 tensin 2
TNS3 tensin 3
TOM1 target of myb1 (chicken)
VAV3 vav 3 guanine nucleotide exchange factor
ZDHHC8 zinc finger, DHHC-type containing 8

decreased phosphorylation

Symbol Name
AXL AXL receptor tyrosine kinase
EPHB4 EPH receptor B4
FGFR1 fibroblast growth factor receptor 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
OPHN1 oligophrenin 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)