PTP1B_KO_PDGF vs basal_MEF (Mouse) [18515860] Gene Set

Dataset SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands
Category proteomics
Type ligand (protein) perturbation
Description ligand (protein) perturbation identified as [ligand perturbation]_[cell line] ([organism]) [[publication PMID]] (SILAC Phosphoproteomics)
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77 proteins differentially phosphorylated following the PTP1B_KO_PDGF vs basal_MEF (Mouse) [18515860] ligand (protein) perturbation from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands dataset.

increased phosphorylation

Symbol Name
ADGRL2 adhesion G protein-coupled receptor L2
ANKRD13A ankyrin repeat domain 13A
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ARHGAP12 Rho GTPase activating protein 12
AXL AXL receptor tyrosine kinase
BCAR1 breast cancer anti-estrogen resistance 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CDK2 cyclin-dependent kinase 2
CTNND1 catenin (cadherin-associated protein), delta 1
CTTN cortactin
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDR2 discoidin domain receptor tyrosine kinase 2
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
EGFR epidermal growth factor receptor
EPHA2 EPH receptor A2
EPHA4 EPH receptor A4
EPHB2 EPH receptor B2
EPHB3 EPH receptor B3
EPHB4 EPH receptor B4
EPN2 epsin 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FER fer (fps/fes related) tyrosine kinase
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
GAREM GRB2 associated, regulator of MAPK1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GJA1 gap junction protein, alpha 1, 43kDa
GRB2 growth factor receptor-bound protein 2
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
IFITM3 interferon induced transmembrane protein 3
INPPL1 inositol polyphosphate phosphatase-like 1
ITSN2 intersectin 2
KIRREL kin of IRRE like (Drosophila)
LPP LIM domain containing preferred translocation partner in lipoma
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MEGF10 multiple EGF-like-domains 10
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PARD3 par-3 family cell polarity regulator
PDGFA platelet-derived growth factor alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PEAK1 pseudopodium-enriched atypical kinase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLCG1 phospholipase C, gamma 1
PTK2 protein tyrosine kinase 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PXN paxillin
RAB1A RAB1A, member RAS oncogene family
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RIN1 Ras and Rab interactor 1
SH3PXD2A SH3 and PX domains 2A
SHANK2 SH3 and multiple ankyrin repeat domains 2
SHB Src homology 2 domain containing adaptor protein B
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC38A2 solute carrier family 38, member 2
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
ST5 suppression of tumorigenicity 5
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TJP1 tight junction protein 1
TNK2 tyrosine kinase, non-receptor, 2
TNS1 tensin 1
TNS2 tensin 2
TNS3 tensin 3
TOM1 target of myb1 (chicken)
VAV3 vav 3 guanine nucleotide exchange factor
ZDHHC8 zinc finger, DHHC-type containing 8

decreased phosphorylation

Symbol Name
FGFR1 fibroblast growth factor receptor 1
OPHN1 oligophrenin 1