PTPN1 Gene Set

Dataset DEPOD Substrates of Phosphatases
Category physical interactions
Type phosphatase
Description protein tyrosine phosphatase, non-receptor type 1|The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013] (NCBI Entrez Gene Database, 5770)
External Link
Similar Terms
Downloads & Tools


37 substrates of the phosphatase PTPN1 from the curated DEPOD Substrates of Phosphatases dataset.

Symbol Name
ACTN1 actinin, alpha 1
BCAR1 breast cancer anti-estrogen resistance 1
CAV1 caveolin 1, caveolae protein, 22kDa
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTTN cortactin
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
EGFR epidermal growth factor receptor
EPHA3 EPH receptor A3
EPOR erythropoietin receptor
ESR1 estrogen receptor 1
GAB1 GRB2-associated binding protein 1
GHR growth hormone receptor
GSK3B glycogen synthase kinase 3 beta
IGF1R insulin-like growth factor 1 receptor
INSR insulin receptor
IRS1 insulin receptor substrate 1
JAK2 Janus kinase 2
LAT linker for activation of T cells
MET MET proto-oncogene, receptor tyrosine kinase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NSF N-ethylmaleimide-sensitive factor
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PLCG1 phospholipase C, gamma 1
PTK2 protein tyrosine kinase 2
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TYK2 tyrosine kinase 2