PTPN11 Gene Set

Dataset DEPOD Substrates of Phosphatases
Category physical interactions
Type phosphatase
Description protein tyrosine phosphatase, non-receptor type 11|The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] (NCBI Entrez Gene Database, 5781)
External Link http://www.koehn.embl.de/depod/showp.php?gene=PTPN11
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Genes

21 substrates of the phosphatase PTPN11 from the curated DEPOD Substrates of Phosphatases dataset.

Symbol Name
ARHGAP5 Rho GTPase activating protein 5
EGFR epidermal growth factor receptor
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
IRS1 insulin receptor substrate 1
JAK2 Janus kinase 2
KDR kinase insert domain receptor
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MPZL1 myelin protein zero-like 1
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PTK2B protein tyrosine kinase 2 beta
PXN paxillin
SELE selectin E
SIRPA signal-regulatory protein alpha
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B