PTPN11 Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description protein tyrosine phosphatase, non-receptor type 11|The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] (NCBI Entrez Gene Database, 5781)
External Link http://www.ncbi.nlm.nih.gov/gene/5781
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167 interacting proteins for hub protein PTPN11 from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACTN4 actinin, alpha 4
ALDOC aldolase C, fructose-bisphosphate
ALK anaplastic lymphoma receptor tyrosine kinase
ANK1 ankyrin 1, erythrocytic
ARHGAP1 Rho GTPase activating protein 1
AXL AXL receptor tyrosine kinase
BCAR1 breast cancer anti-estrogen resistance 1
BCR breakpoint cluster region
BDKRB2 bradykinin receptor B2
BTLA B and T lymphocyte associated
C6ORF25 chromosome 6 open reading frame 25
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCKBR cholecystokinin B receptor
CD33 CD33 molecule
CD84 CD84 molecule
CDH5 cadherin 5, type 2 (vascular endothelium)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHUK conserved helix-loop-helix ubiquitous kinase
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSF3R colony stimulating factor 3 receptor (granulocyte)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
CXCR4 chemokine (C-X-C motif) receptor 4
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
DDR1 discoidin domain receptor tyrosine kinase 1
EGFR epidermal growth factor receptor
EPB41 erythrocyte membrane protein band 4.1
EPB42 erythrocyte membrane protein band 4.2
EPHA2 EPH receptor A2
EPOR erythropoietin receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCRL3 Fc receptor-like 3
FGFR3 fibroblast growth factor receptor 3
FLT1 fms-related tyrosine kinase 1
FLT4 fms-related tyrosine kinase 4
FRS2 fibroblast growth factor receptor substrate 2
FRS3 fibroblast growth factor receptor substrate 3
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
GAB3 GRB2-associated binding protein 3
GAB4 GRB2-associated binding protein family, member 4
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GHR growth hormone receptor
GRB2 growth factor receptor-bound protein 2
GRB7 growth factor receptor-bound protein 7
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
HBA2 hemoglobin, alpha 2
HEATR6 HEAT repeat containing 6
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IGF1R insulin-like growth factor 1 receptor
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL22RA1 interleukin 22 receptor, alpha 1
IL4R interleukin 4 receptor
IL6ST interleukin 6 signal transducer
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
INSR insulin receptor
IRF8 interferon regulatory factor 8
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
KDR kinase insert domain receptor
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLRC1 killer cell lectin-like receptor subfamily C, member 1
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAT linker for activation of T cells
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LEPR leptin receptor
LIFR leukemia inhibitory factor receptor alpha
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LUC7L3 LUC7-like 3 (S. cerevisiae)
LY9 lymphocyte antigen 9
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK3 mitogen-activated protein kinase 3
MET MET proto-oncogene, receptor tyrosine kinase
MPL MPL proto-oncogene, thrombopoietin receptor
MPZL1 myelin protein zero-like 1
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
MVP major vault protein
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
PFKM phosphofructokinase, muscle
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PILRA paired immunoglobin-like type 2 receptor alpha
PILRB paired immunoglobin-like type 2 receptor beta
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCH protein kinase C, eta
PRLR prolactin receptor
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PXN paxillin
RET ret proto-oncogene
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
S100A8 S100 calcium binding protein A8
SELE selectin E
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIGLEC11 sialic acid binding Ig-like lectin 11
SIGLEC12 sialic acid binding Ig-like lectin 12 (gene/pseudogene)
SIGLEC5 sialic acid binding Ig-like lectin 5
SIGLEC7 sialic acid binding Ig-like lectin 7
SIGLEC9 sialic acid binding Ig-like lectin 9
SIRPA signal-regulatory protein alpha
SIT1 signaling threshold regulating transmembrane adaptor 1
SLAMF1 signaling lymphocytic activation molecule family member 1
SLAMF6 SLAM family member 6
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SOCS3 suppressor of cytokine signaling 3
SOS1 son of sevenless homolog 1 (Drosophila)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
SYK spleen tyrosine kinase
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBK1 TANK-binding kinase 1
TEK TEK tyrosine kinase, endothelial
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TREML1 triggering receptor expressed on myeloid cells-like 1
TYK2 tyrosine kinase 2
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor