PTPN11 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description protein tyrosine phosphatase, non-receptor type 11|The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] (NCBI Entrez Gene Database, 5781)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/MORF_PTPN11
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Genes

108 co-expressed genes for PTPN11 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ACOT13 acyl-CoA thioesterase 13
ACOT7 acyl-CoA thioesterase 7
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
ATP5J ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BUB3 BUB3 mitotic checkpoint protein
CBFB core-binding factor, beta subunit
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CCT8 chaperonin containing TCP1, subunit 8 (theta)
CDC123 cell division cycle 123
CDK4 cyclin-dependent kinase 4
CHERP calcium homeostasis endoplasmic reticulum protein
CSNK2B casein kinase 2, beta polypeptide
CYCS cytochrome c, somatic
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2)
EID1 EP300 interacting inhibitor of differentiation 1
EIF3B eukaryotic translation initiation factor 3, subunit B
FEN1 flap structure-specific endonuclease 1
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GMPS guanine monphosphate synthase
H2AFZ H2A histone family, member Z
HAT1 histone acetyltransferase 1
HCCS holocytochrome c synthase
HDDC2 HD domain containing 2
HNRNPR heterogeneous nuclear ribonucleoprotein R
HSPA9 heat shock 70kDa protein 9 (mortalin)
IFRD1 interferon-related developmental regulator 1
ILF3 interleukin enhancer binding factor 3, 90kDa
IRAK1 interleukin-1 receptor-associated kinase 1
KHSRP KH-type splicing regulatory protein
KIDINS220 kinase D-interacting substrate, 220kDa
KIF11 kinesin family member 11
LAGE3 L antigen family, member 3
LARP1 La ribonucleoprotein domain family, member 1
LMNB2 lamin B2
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAGOH mago-nashi homolog, proliferation-associated (Drosophila)
MAPRE1 microtubule-associated protein, RP/EB family, member 1
MCM6 minichromosome maintenance complex component 6
MFAP1 microfibrillar-associated protein 1
MOGS mannosyl-oligosaccharide glucosidase
MPV17 MpV17 mitochondrial inner membrane protein
MRFAP1L1 Morf4 family associated protein 1-like 1
MTDH metadherin
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit
NARS asparaginyl-tRNA synthetase
NDC80 NDC80 kinetochore complex component
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
NHP2 NHP2 ribonucleoprotein
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUP205 nucleoporin 205kDa
PARK7 parkinson protein 7
PDIA6 protein disulfide isomerase family A, member 6
PMEL premelanosome protein
PPID peptidylprolyl isomerase D
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PRRC2C proline-rich coiled-coil 2C
PTGES3 prostaglandin E synthase 3 (cytosolic)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
R3HDM1 R3H domain containing 1
RAD1 RAD1 checkpoint DNA exonuclease
RAD23A RAD23 homolog A (S. cerevisiae)
RBM14 RNA binding motif protein 14
RFC2 replication factor C (activator 1) 2, 40kDa
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
SCAMP3 secretory carrier membrane protein 3
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SET SET nuclear proto-oncogene
SF3B2 splicing factor 3b, subunit 2, 145kDa
SLBP stem-loop binding protein
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SMC3 structural maintenance of chromosomes 3
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa
SOD1 superoxide dismutase 1, soluble
SRSF1 serine/arginine-rich splicing factor 1
SRSF9 serine/arginine-rich splicing factor 9
SSBP1 single-stranded DNA binding protein 1, mitochondrial
TARDBP TAR DNA binding protein
TARS threonyl-tRNA synthetase
THAP11 THAP domain containing 11
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TRIM28 tripartite motif containing 28
UBE2N ubiquitin-conjugating enzyme E2N
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VAMP7 vesicle-associated membrane protein 7
VBP1 von Hippel-Lindau binding protein 1
VDAC1 voltage-dependent anion channel 1
VDAC2 voltage-dependent anion channel 2
VPS26A vacuolar protein sorting 26 homolog A (S. pombe)
XPOT exportin, tRNA