PTPN13 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)|The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008] (NCBI Entrez Gene Database, 5783)
External Link http://www.ncbi.nlm.nih.gov/gene/5783
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301 interacting proteins for PTPN13 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABLIM1 actin binding LIM protein 1
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
AMOT angiomotin
AMOTL1 angiomotin like 1
AMPD2 adenosine monophosphate deaminase 2
ANAPC1 anaphase promoting complex subunit 1
ANAPC5 anaphase promoting complex subunit 5
ANXA1 annexin A1
APC adenomatous polyposis coli
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARHGAP29 Rho GTPase activating protein 29
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAD BCL2-associated agonist of cell death
BAIAP2 BAI1-associated protein 2
BLK BLK proto-oncogene, Src family tyrosine kinase
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRD7 bromodomain containing 7
C1ORF35 chromosome 1 open reading frame 35
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC6 coiled-coil domain containing 6
CCDC85C coiled-coil domain containing 85C
CCP110 centriolar coiled coil protein 110kDa
CDC25C cell division cycle 25C
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDK16 cyclin-dependent kinase 16
CDK17 cyclin-dependent kinase 17
CDK18 cyclin-dependent kinase 18
CENPJ centromere protein J
CEP152 centrosomal protein 152kDa
CEP170 centrosomal protein 170kDa
CEP170B centrosomal protein 170B
CEP192 centrosomal protein 192kDa
CEP72 centrosomal protein 72kDa
CEP85 centrosomal protein 85kDa
CGN cingulin
CLASP1 cytoplasmic linker associated protein 1
CLASP2 cytoplasmic linker associated protein 2
CNTROB centrobin, centrosomal BRCA2 interacting protein
CPVL carboxypeptidase, vitellogenic-like
CRIP2 cysteine-rich protein 2
CRTC2 CREB regulated transcription coactivator 2
CRTC3 CREB regulated transcription coactivator 3
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2B casein kinase 2, beta polypeptide
CSPP1 centrosome and spindle pole associated protein 1
CSTA cystatin A (stefin A)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSD cathepsin D
CUL7 cullin 7
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYLD cylindromatosis (turban tumor syndrome)
DCAF7 DDB1 and CUL4 associated factor 7
DDB1 damage-specific DNA binding protein 1, 127kDa
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DENND1A DENN/MADD domain containing 1A
DENND4A DENN/MADD domain containing 4A
DENND4C DENN/MADD domain containing 4C
DMTN dematin actin binding protein
DOCK11 dedicator of cytokinesis 11
DOCK7 dedicator of cytokinesis 7
DVL1 dishevelled segment polarity protein 1
DVL2 dishevelled segment polarity protein 2
DVL3 dishevelled segment polarity protein 3
EDC3 enhancer of mRNA decapping 3
EFNB1 ephrin-B1
EFNB2 ephrin-B2
EIF4E2 eukaryotic translation initiation factor 4E family member 2
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPHB1 EPH receptor B1
EPHB2 EPH receptor B2
EXO1 exonuclease 1
FADD Fas (TNFRSF6)-associated via death domain
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FASN fatty acid synthase
FBXL16 F-box and leucine-rich repeat protein 16
FBXL2 F-box and leucine-rich repeat protein 2
FGR FGR proto-oncogene, Src family tyrosine kinase
FOXO3 forkhead box O3
FUBP3 far upstream element (FUSE) binding protein 3
FYN FYN proto-oncogene, Src family tyrosine kinase
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAPVD1 GTPase activating protein and VPS9 domains 1
GDI2 GDP dissociation inhibitor 2
GGCT gamma-glutamylcyclotransferase
GHR growth hormone receptor
GIGYF1 GRB10 interacting GYF protein 1
GIGYF2 GRB10 interacting GYF protein 2
GOPC golgi-associated PDZ and coiled-coil motif containing
GRIP1 glutamate receptor interacting protein 1
HCK HCK proto-oncogene, Src family tyrosine kinase
HDAC4 histone deacetylase 4
HDAC5 histone deacetylase 5
HDAC7 histone deacetylase 7
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HNF4A hepatocyte nuclear factor 4, alpha
HSPA1B heat shock 70kDa protein 1B
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
INADL InaD-like (Drosophila)
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
KCMF1 potassium channel modulatory factor 1
KIAA0355 KIAA0355
KIAA0368 KIAA0368
KIAA0930 KIAA0930
KIAA1462 KIAA1462
KIAA1549 KIAA1549
KIAA1671 KIAA1671
KIF1B kinesin family member 1B
KIF1C kinesin family member 1C
KIRREL kin of IRRE like (Drosophila)
KLC2 kinesin light chain 2
KLC4 kinesin light chain 4
KSR1 kinase suppressor of ras 1
LARP1 La ribonucleoprotein domain family, member 1
LATS1 large tumor suppressor kinase 1
LATS2 large tumor suppressor kinase 2
LCK LCK proto-oncogene, Src family tyrosine kinase
LETM1 leucine zipper-EF-hand containing transmembrane protein 1
LIMA1 LIM domain and actin binding 1
LIMD1 LIM domains containing 1
LIN7C lin-7 homolog C (C. elegans)
LMO7 LIM domain 7
LNX2 ligand of numb-protein X 2
LONP1 lon peptidase 1, mitochondrial
LRCH2 leucine-rich repeats and calponin homology (CH) domain containing 2
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LUZP1 leucine zipper protein 1
LYN LYN proto-oncogene, Src family tyrosine kinase
LZTS2 leucine zipper, putative tumor suppressor 2
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MARK1 MAP/microtubule affinity-regulating kinase 1
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK3 MAP/microtubule affinity-regulating kinase 3
MAST2 microtubule associated serine/threonine kinase 2
MCM7 minichromosome maintenance complex component 7
MIPOL1 mirror-image polydactyly 1
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MOB1A MOB kinase activator 1A
MPDZ multiple PDZ domain protein
MPHOSPH9 M-phase phosphoprotein 9
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
MTMR12 myotubularin related protein 12
NADK NAD kinase
NAV1 neuron navigator 1
NCK1 NCK adaptor protein 1
NCK2 NCK adaptor protein 2
NCKAP1 NCK-associated protein 1
NCKAP5L NCK-associated protein 5-like
NCKIPSD NCK interacting protein with SH3 domain
NELFA negative elongation factor complex member A
NELFB negative elongation factor complex member B
NF1 neurofibromin 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFR nerve growth factor receptor
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NIN ninein (GSK3B interacting protein)
NINL ninein-like
NME7 NME/NM23 family member 7
NOTCH1 notch 1
NOTCH2 notch 2
OFD1 oral-facial-digital syndrome 1
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PARD3 par-3 family cell polarity regulator
PARP8 poly (ADP-ribose) polymerase family, member 8
PCBP1 poly(rC) binding protein 1
PDCD10 programmed cell death 10
PDLIM4 PDZ and LIM domain 4
PDZD11 PDZ domain containing 11
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PHLDB2 pleckstrin homology-like domain, family B, member 2
PI4KB phosphatidylinositol 4-kinase, catalytic, beta
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PKN2 protein kinase N2
PKP2 plakophilin 2
PKP4 plakophilin 4
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLEKHA7 pleckstrin homology domain containing, family A member 7
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
PNMA2 paraneoplastic Ma antigen 2
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PRICKLE1 prickle homolog 1 (Drosophila)
PRICKLE3 prickle homolog 3 (Drosophila)
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRMT1 protein arginine methyltransferase 1
PTK2 protein tyrosine kinase 2
PTPN14 protein tyrosine phosphatase, non-receptor type 14
PUM1 pumilio RNA-binding family member 1
R3HDM1 R3H domain containing 1
R3HDM2 R3H domain containing 2
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RADIL Ras association and DIL domains
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RASAL2 RAS protein activator like 2
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
RBBP4 retinoblastoma binding protein 4
RBM15 RNA binding motif protein 15
RCN2 reticulocalbin 2, EF-hand calcium binding domain
REEP4 receptor accessory protein 4
RICTOR RPTOR independent companion of MTOR, complex 2
RTKN rhotekin
S100A14 S100 calcium binding protein A14
S100A7 S100 calcium binding protein A7
SACK1B scaffolding CK1 anchoring protein B
SAMD4A sterile alpha motif domain containing 4A
SAMD4B sterile alpha motif domain containing 4B
SDCCAG3 serologically defined colon cancer antigen 3
SEC16A SEC16 homolog A (S. cerevisiae)
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SH3PXD2A SH3 and PX domains 2A
SH3RF1 SH3 domain containing ring finger 1
SH3RF3 SH3 domain containing ring finger 3
SHKBP1 SH3KBP1 binding protein 1
SHROOM3 shroom family member 3
SIPA1L1 signal-induced proliferation-associated 1 like 1
SIPA1L2 signal-induced proliferation-associated 1 like 2
SIPA1L3 signal-induced proliferation-associated 1 like 3
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)
SKP1 S-phase kinase-associated protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMR3B submaxillary gland androgen regulated protein 3B
SNX27 sorting nexin family member 27
SORBS1 sorbin and SH3 domain containing 1
SORBS2 sorbin and SH3 domain containing 2
SPICE1 spindle and centriole associated protein 1
SPRR2E small proline-rich protein 2E
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
SRRM2 serine/arginine repetitive matrix 2
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STK25 serine/threonine kinase 25
STK3 serine/threonine kinase 3
STXBP4 syntaxin binding protein 4
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TBC1D22A TBC1 domain family, member 22A
TBC1D22B TBC1 domain family, member 22B
TBC1D4 TBC1 domain family, member 4
TBC1D5 TBC1 domain family, member 5
TBK1 TANK-binding kinase 1
TBKBP1 TBK1 binding protein 1
TCHP trichoplein, keratin filament binding
TJP1 tight junction protein 1
TJP2 tight junction protein 2
TNRC6B trinucleotide repeat containing 6B
TP53BP2 tumor protein p53 binding protein 2
TPD52L1 tumor protein D52-like 1
TRIM32 tripartite motif containing 32
TRIP6 thyroid hormone receptor interactor 6
TSC2 tuberous sclerosis 2
TTC28 tetratricopeptide repeat domain 28
TUBB2A tubulin, beta 2A class IIa
TUBB6 tubulin, beta 6 class V
UBC ubiquitin C
UHRF1BP1L UHRF1 binding protein 1-like
USP54 ubiquitin specific peptidase 54
USP8 ubiquitin specific peptidase 8
USP9X ubiquitin specific peptidase 9, X-linked
UTRN utrophin
VANGL1 VANGL planar cell polarity protein 1
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
VPS33B vacuolar protein sorting 33 homolog B (yeast)
WNK1 WNK lysine deficient protein kinase 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZCCHC8 zinc finger, CCHC domain containing 8
ZFP36L2 ZFP36 ring finger protein-like 2