PTPN6 Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description protein tyrosine phosphatase, non-receptor type 6|The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5777)
External Link http://www.ncbi.nlm.nih.gov/gene/5777
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168 interacting proteins for hub protein PTPN6 from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACTN1 actinin, alpha 1
ACTN4 actinin, alpha 4
AP2A1 adaptor-related protein complex 2, alpha 1 subunit
BCR breakpoint cluster region
BLNK B-cell linker
BTK Bruton agammaglobulinemia tyrosine kinase
BTLA B and T lymphocyte associated
C6ORF25 chromosome 6 open reading frame 25
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD19 CD19 molecule
CD22 CD22 molecule
CD247 CD247 molecule
CD300LF CD300 molecule-like family member f
CD33 CD33 molecule
CD46 CD46 molecule, complement regulatory protein
CD5 CD5 molecule
CD72 CD72 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CDC5L cell division cycle 5-like
CDK2 cyclin-dependent kinase 2
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CLEC4A C-type lectin domain family 4, member A
CNTFR ciliary neurotrophic factor receptor
CRLF2 cytokine receptor-like factor 2
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSF3R colony stimulating factor 3 receptor (granulocyte)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
CUZD1 CUB and zona pellucida-like domains 1
CXCR4 chemokine (C-X-C motif) receptor 4
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
EGFR epidermal growth factor receptor
EPOR erythropoietin receptor
ESR1 estrogen receptor 1
FAS Fas cell surface death receptor
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCRL3 Fc receptor-like 3
FLT3 fms-related tyrosine kinase 3
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB2 GRB2-associated binding protein 2
GALT galactose-1-phosphate uridylyltransferase
GHR growth hormone receptor
GRB2 growth factor receptor-bound protein 2
HBA1 hemoglobin, alpha 1
HOXA10 homeobox A10
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IFNLR1 interferon, lambda receptor 1
IL10RA interleukin 10 receptor, alpha
IL10RB interleukin 10 receptor, beta
IL11RA interleukin 11 receptor, alpha
IL12RB1 interleukin 12 receptor, beta 1
IL12RB2 interleukin 12 receptor, beta 2
IL13RA1 interleukin 13 receptor, alpha 1
IL13RA2 interleukin 13 receptor, alpha 2
IL15RA interleukin 15 receptor, alpha
IL20RA interleukin 20 receptor, alpha
IL20RB interleukin 20 receptor beta
IL21R interleukin 21 receptor
IL22RA1 interleukin 22 receptor, alpha 1
IL22RA2 interleukin 22 receptor, alpha 2
IL23R interleukin 23 receptor
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IL3RA interleukin 3 receptor, alpha (low affinity)
IL4R interleukin 4 receptor
IL5RA interleukin 5 receptor, alpha
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
IL7R interleukin 7 receptor
IL9R interleukin 9 receptor
INSR insulin receptor
IRAK1 interleukin-1 receptor-associated kinase 1
IRF1 interferon regulatory factor 1
IRF8 interferon regulatory factor 8
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
KDR kinase insert domain receptor
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLRAP1 killer cell lectin-like receptor subfamily A pseudogene 1
KLRB1 killer cell lectin-like receptor subfamily B, member 1
KLRC1 killer cell lectin-like receptor subfamily C, member 1
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAT linker for activation of T cells
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LEPR leptin receptor
LIFR leukemia inhibitory factor receptor alpha
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MPL MPL proto-oncogene, thrombopoietin receptor
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
MYH9 myosin, heavy chain 9, non-muscle
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NOS1 nitric oxide synthase 1 (neuronal)
NR5A2 nuclear receptor subfamily 5, group A, member 2
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
OSMR oncostatin M receptor
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PDCD1 programmed cell death 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PILRA paired immunoglobin-like type 2 receptor alpha
PILRB paired immunoglobin-like type 2 receptor beta
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PRKCQ protein kinase C, theta
PRLR prolactin receptor
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIGLEC10 sialic acid binding Ig-like lectin 10
SIGLEC11 sialic acid binding Ig-like lectin 11
SIGLEC12 sialic acid binding Ig-like lectin 12 (gene/pseudogene)
SIGLEC5 sialic acid binding Ig-like lectin 5
SIGLEC7 sialic acid binding Ig-like lectin 7
SIGLEC9 sialic acid binding Ig-like lectin 9
SIRPA signal-regulatory protein alpha
SLAMF6 SLAM family member 6
SMAD3 SMAD family member 3
SOS1 son of sevenless homolog 1 (Drosophila)
SPATA2 spermatogenesis associated 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSTR2 somatostatin receptor 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SYK spleen tyrosine kinase
TFG TRK-fused gene
TLR10 toll-like receptor 10
TLR2 toll-like receptor 2
TMEM62 transmembrane protein 62
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TREML1 triggering receptor expressed on myeloid cells-like 1
TYK2 tyrosine kinase 2
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa