PTPN6 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description protein tyrosine phosphatase, non-receptor type 6|The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5777)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GNF2_PTPN6
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Genes

47 co-expressed genes for PTPN6 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
ANXA11 annexin A11
ARHGAP25 Rho GTPase activating protein 25
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa
B2M beta-2-microglobulin
C17ORF62 chromosome 17 open reading frame 62
CD48 CD48 molecule
CD53 CD53 molecule
CORO1A coronin, actin binding protein, 1A
CORO7 coronin 7
CRLF3 cytokine receptor-like factor 3
DPEP2 dipeptidase 2
EMP3 epithelial membrane protein 3
EVI2B ecotropic viral integration site 2B
FAM49B family with sequence similarity 49, member B
FAM65B family with sequence similarity 65, member B
FMNL1 formin-like 1
FXYD5 FXYD domain containing ion transport regulator 5
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GMIP GEM interacting protein
GPSM3 G-protein signaling modulator 3
GRK6 G protein-coupled receptor kinase 6
HCLS1 hematopoietic cell-specific Lyn substrate 1
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
ICAM3 intercellular adhesion molecule 3
LAPTM5 lysosomal protein transmembrane 5
LIMD2 LIM domain containing 2
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LSP1 lymphocyte-specific protein 1
LYN LYN proto-oncogene, Src family tyrosine kinase
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
SELL selectin L
SIPA1 signal-induced proliferation-associated 1
SP110 SP110 nuclear body protein
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TAPBP TAP binding protein (tapasin)
TXNIP thioredoxin interacting protein
WAS Wiskott-Aldrich syndrome