PTPRA Gene Set

Dataset DEPOD Substrates of Phosphatases
Category physical interactions
Type phosphatase
Description protein tyrosine phosphatase, receptor type, A|The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5786)
External Link http://www.koehn.embl.de/depod/showp.php?gene=PTPRA
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Genes

5 substrates of the phosphatase PTPRA from the curated DEPOD Substrates of Phosphatases dataset.

Symbol Name
BCAR1 breast cancer anti-estrogen resistance 1
FYN FYN proto-oncogene, Src family tyrosine kinase
LYN LYN proto-oncogene, Src family tyrosine kinase
PTPRA protein tyrosine phosphatase, receptor type, A
SRC SRC proto-oncogene, non-receptor tyrosine kinase