PTPRC Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description protein tyrosine phosphatase, receptor type, C|The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012] (NCBI Entrez Gene Database, 5788)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GNF2_PTPRC
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Genes

68 co-expressed genes for PTPRC from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ADAM8 ADAM metallopeptidase domain 8
ADCY7 adenylate cyclase 7
ADGRE5 adhesion G protein-coupled receptor E5
ARHGAP4 Rho GTPase activating protein 4
BIN2 bridging integrator 2
BTN3A3 butyrophilin, subfamily 3, member A3
C11ORF21 chromosome 11 open reading frame 21
CASP8 caspase 8, apoptosis-related cysteine peptidase
CD48 CD48 molecule
CD53 CD53 molecule
CLEC2B C-type lectin domain family 2, member B
CORO1A coronin, actin binding protein, 1A
CYTH1 cytohesin 1
CYTIP cytohesin 1 interacting protein
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
FAM65B family with sequence similarity 65, member B
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FMNL1 formin-like 1
FYB FYN binding protein
GIMAP6 GTPase, IMAP family member 6
GPR65 G protein-coupled receptor 65
GRK6 G protein-coupled receptor kinase 6
GSAP gamma-secretase activating protein
HCLS1 hematopoietic cell-specific Lyn substrate 1
HECA headcase homolog (Drosophila)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HMHA1 histocompatibility (minor) HA-1
ICAM3 intercellular adhesion molecule 3
IL10RA interleukin 10 receptor, alpha
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
JAK1 Janus kinase 1
KDM5A lysine (K)-specific demethylase 5A
KLF2 Kruppel-like factor 2
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
MBNL1 muscleblind-like splicing regulator 1
MSL1 male-specific lethal 1 homolog (Drosophila)
OSTF1 osteoclast stimulating factor 1
PARP12 poly (ADP-ribose) polymerase family, member 12
PARP8 poly (ADP-ribose) polymerase family, member 8
PHF11 PHD finger protein 11
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAP1B RAP1B, member of RAS oncogene family
RIN3 Ras and Rab interactor 3
RNF44 ring finger protein 44
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SIPA1 signal-induced proliferation-associated 1
SNRK SNF related kinase
SNX6 sorting nexin 6
STK10 serine/threonine kinase 10
STK38 serine/threonine kinase 38
TRAF3IP3 TRAF3 interacting protein 3
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VAV1 vav 1 guanine nucleotide exchange factor
WAS Wiskott-Aldrich syndrome
WIPF1 WAS/WASL interacting protein family, member 1
ZCCHC6 zinc finger, CCHC domain containing 6
ZNF394 zinc finger protein 394