PTPRE Gene Set

Dataset DEPOD Substrates of Phosphatases
Category physical interactions
Type phosphatase
Description protein tyrosine phosphatase, receptor type, E|The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5791)
External Link http://www.koehn.embl.de/depod/showp.php?gene=PTPRE
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Genes

7 substrates of the phosphatase PTPRE from the curated DEPOD Substrates of Phosphatases dataset.

Symbol Name
FYN FYN proto-oncogene, Src family tyrosine kinase
INSR insulin receptor
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
SRC SRC proto-oncogene, non-receptor tyrosine kinase
YES1 YES proto-oncogene 1, Src family tyrosine kinase